Reactome | ISG-K164,ISG-K168-PCNA [nucleoplasm]

ISG-K164,ISG-K168-PCNA [nucleoplasm]

Stable Identifier

R-HSA-5653768

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

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Locations in the PathwayBrowser

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DNA Repair (Homo sapiens)

- DNA Damage Bypass (Homo sapiens)
  - Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template (Homo sapiens)
    - Termination of translesion DNA synthesis (Homo sapiens)
      - UBE2L6:TRIM25 ISGylates monoUb:K164-PCNA (Homo sapiens)
        
        DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        ISG-K164,ISG-K168-PCNA [nucleoplasm] (Homo sapiens)
      - USP10 binds monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)
        
        DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        ISG-K164,ISG-K168-PCNA [nucleoplasm] (Homo sapiens)
        
        USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        ISG-K164,ISG-K168-PCNA [nucleoplasm] (Homo sapiens)
      - USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        ISG-K164,ISG-K168-PCNA [nucleoplasm] (Homo sapiens)
        
        USP10:DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        DNA polymerase Y:MonoUb:K164,ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        MonoUb:K164,ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        ISG-K164,ISG-K168-PCNA [nucleoplasm] (Homo sapiens)
      - USP43 binds ISG:K164,ISG:K168-PCNA (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        ISG-K164,ISG-K168-PCNA [nucleoplasm] (Homo sapiens)
        
        USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        ISG-K164,ISG-K168-PCNA [nucleoplasm] (Homo sapiens)
      - USP43 deISGylates ISG:K164,ISG:K168-PCNA (Homo sapiens)
        
        USP43:ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA:RPA:RFC:TLS-DNA Template [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA homotrimer [nucleoplasm] (Homo sapiens)
        
        ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)
        
        ISG-K164,ISG-K168-PCNA [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P12004 PCNA

Gene Names

PCNA

Chain

chain:1-261

Reference Genes

BioGPS Gene:5111 PCNA

COSMIC (genes):PCNA PCNA

CTD Gene:5111 PCNA

dbSNP Gene:5111 PCNA

ENSEMBL:ENSG00000132646 PCNA

ENSEMBL_homo_sapiens_GENE:ENSG00000132646.11 PCNA

HGNC:8729 PCNA

KEGG Gene (Homo sapiens):5111 PCNA

Monarch:5111 PCNA

NCBI Gene:5111 PCNA

OMIM:176740 PCNA

UCSC:P12004 PCNA

Reference Transcript

Other Identifiers

11716103_a_at

16916958

1824_s_at

1884_s_at

201202_PM_at

201202_at

3896201

3896202

3896203

3896204

3896206

3896207

3896209

3896211

3896213

3896214

3896215

3896216

4006657

4006658

5111

8064844

A_23_P28886

A_33_P3258612

GE61312

GO:0000122

GO:0000228

GO:0000278

GO:0000307

GO:0000701

GO:0000781

GO:0000785

GO:0001673

GO:0003677

GO:0003682

GO:0003684

GO:0003824

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005652

GO:0005654

GO:0005657

GO:0005694

GO:0005813

GO:0005815

GO:0005856

GO:0006260

GO:0006272

GO:0006275

GO:0006281

GO:0006287

GO:0006298

GO:0006351

GO:0006355

GO:0006974

GO:0006979

GO:0007507

GO:0016604

GO:0016787

GO:0019899

GO:0019985

GO:0022414

GO:0030154

GO:0030331

GO:0030337

GO:0030855

GO:0030894

GO:0030971

GO:0031297

GO:0032077

GO:0032139

GO:0032200

GO:0032355

GO:0032405

GO:0033993

GO:0034644

GO:0035035

GO:0042802

GO:0043226

GO:0043596

GO:0043626

GO:0044849

GO:0044877

GO:0045739

GO:0045740

GO:0046686

GO:0048856

GO:0070062

GO:0070182

GO:0070301

GO:0070557

GO:0071466

GO:0071548

GO:0097421

GO:0098772

GO:0140097

GO:1900264

GO:1902065

GO:1902990

HMNXSV003000505

HMNXSV003026895

ILMN_1685682

ILMN_1694177

ILMN_1706958

J05614_at

M15796_at

PH_hs_0028994

TC20000592.hg

g4505640_3p_at

Participates

as a component of

ISG:K164,ISG:K168-PCNA [nucleoplasm] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K164,K254,K-PCNA [nucleoplasm]

K63polyUb-K164-PCNA [nucleoplasm]

MonoUb-K164-PCNA [nucleoplasm]

PCNA [nucleoplasm]

Inferred To

PCNA [nucleoplasm] (Bos taurus)

PCNA [nucleoplasm] (Canis familiaris)

PCNA [nucleoplasm] (Drosophila melanogaster)

PCNA [nucleoplasm] (Gallus gallus)

PCNA [nucleoplasm] (Sus scrofa)

PCNA1 [nucleoplasm] (Plasmodium falciparum)

pcna [nucleoplasm] (Dictyostelium discoideum)

pcna [nucleoplasm] (Xenopus tropicalis)

Pcna [nucleoplasm] (Mus musculus)

Pcna [nucleoplasm] (Rattus norvegicus)

POL30 [nucleoplasm] (Saccharomyces cerevisiae)

pcn-1 [nucleoplasm] (Caenorhabditis elegans)

pcn1 [nucleoplasm] (Schizosaccharomyces pombe)

Modified Residues

Name

Inter-chain Crosslink via N6-glycyl-L-lysine at 164 and 157

Coordinate

164

PsiMod Name

N6-glycyl-L-lysine

PsiMod Definition

A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine.

Name

Inter-chain Crosslink via N6-glycyl-L-lysine at 168 and 157

Coordinate

168

PsiMod Name

N6-glycyl-L-lysine

PsiMod Definition

A protein modification that effectively crosslinks an L-lysine residue and a glycine residue by an isopeptide bond to form N6-glycyl-L-lysine.

Cross References

RefSeq

NP_872590.1, NP_002583.1

ZINC - World Drugs

PCNA_HUMAN

OpenTargets

ENSG00000132646

ZINC - FDA approved

PCNA_HUMAN

ZINC - Substances

PCNA_HUMAN

ZINC - Biogenic

PCNA_HUMAN

ZINC target

P12004

PRO

P12004

PDB

1U7B, 3WGW, 5E0V, 7EFA, 7M5L, 5E0U, 7KQ0, 4D2G, 1UL1, 6TNZ, 6QCG, 5E0T, 6HVO, 4RJF, 7M5N, 5MLO, 6K3A, 1W60, 6EHT, 1U76, 8COB, 5MAV, 6CBI, 6GIS, 5MOM, 7QO1, 2ZVL, 6FCN, 6FCM, 2ZVM, 3TBL, 7QNZ, 2ZVK, 7NV0, 7NV1, 5YD8, 5MLW, 1VYM, 8GL9, 7KQ1, 7M5M, 3VKX, 3P87, 6TNY, 4ZTD, 8E84, 5YCO, 8F5Q, 8GLA, 1VYJ, 6VVO, 6S1O, 8B8T, 5IY4, 1AXC, 6QC0, 6S1N, 6S1M, 6GWS, 3JA9

ZINC - Metabolites

PCNA_HUMAN

GeneCards

P12004

HPA

ENSG00000132646-PCNA

Ensembl

ENST00000379143, ENSP00000368458, ENSP00000368438, ENST00000379160, ENSG00000132646

Pharos - Targets

P12004

Orphanet

23426

ZINC - Predictions - Purchasable

PCNA_HUMAN

Interactors (56)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38936 CDKN1A	5	p-T145-CDKN1A [cytosol] (R-HSA-198614) p-Y77-CDKN1A [cytosol] (R-HSA-8942601) CDKN1A [cytosol] (R-HSA-182512) CDKN1A [nucleoplasm] (R-HSA-182585) p-S130-CDKN1A [nucleoplasm] (R-HSA-187857)	0.977	39
UniProt:P39748 FEN1	1	FEN1 [nucleoplasm] (R-HSA-54745)	0.964	22
UniProt:P12004 PCNA	5	monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) PCNA [nucleoplasm] (R-HSA-68439)	0.898	11
UniProt:Q15054 POLD3	1	POLD3 [nucleoplasm] (R-HSA-68445)	0.83	7
IntAct:EBI-4399559 UBIQ			0.811	7
UniProt:Q15004 PCLAF	2	KIAA0101 [nucleoplasm] (R-HSA-5655178) MonoUb-K15,K24-KIAA0101 [nucleoplasm] (R-HSA-5655182)	0.8	7
UniProt:Q13111 CAF1A			0.734	4
UniProt:P20585 MSH3	2	MSH3 K383Rfs*32 [nucleoplasm] (R-HSA-5578664) MSH3 [nucleoplasm] (R-HSA-5357519)	0.718	6
UniProt:P49005 POLD2	1	POLD2 [nucleoplasm] (R-HSA-68443)	0.678	3
UniProt:O95944 NCR2	1	NCR2 [plasma membrane] (R-HSA-197652)	0.672	7
UniProt:P28340 POLD1	2	POLD1 [nucleoplasm] (R-HSA-68449) POLD1 [cytosol] (R-HSA-2564763)	0.669	3
UniProt:A2RU14 TM218			0.666	4
UniProt:Q9Z111 GA45G			0.664	9
UniProt:P24941 CDK2	5	p-Y15-CDK2 [nucleoplasm] (R-HSA-187905) p-CDK2 [nucleoplasm] (R-HSA-68370) CDK2 [cytosol] (R-HSA-157440) CDK2 [nucleoplasm] (R-HSA-68365) p-T160-CDK2 [nucleoplasm] (R-HSA-187967)	0.643	4
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	14
UniProt:P42771 CDKN2A	20	p16INK4A D84G [cytosol] (R-HSA-9632461) p16INK4A E88* [cytosol] (R-HSA-9632588) p16INK4A R87P [cytosol] (R-HSA-9632335) p16INK4A V126D [cytosol] (R-HSA-9631055) p16INK4A W110* [cytosol] (R-HSA-9632585) p16INK4A D84H [cytosol] (R-HSA-9632489) p16INK4A R80* [cytosol] (R-HSA-9632586) p16INK4A P114L [cytosol] (R-HSA-9630916) p16INK4A R58* [cytosol] (R-HSA-9632582) p16INK4A D84N [cytosol] (R-HSA-9632483) p16INK4A M53I [cytosol] (R-HSA-9630911) p16INK4A D84Y [cytosol] (R-HSA-9632478) p16INK4A G101W [cytosol] (R-HSA-9631257) p16INK4A P81L [cytosol] (R-HSA-9632280) p16INK4A A20P [cytosol] (R-HSA-9630805) p16INK4A D84V [cytosol] (R-HSA-9632465) p16INK4A P81T [cytosol] (R-HSA-9632275) p16INK4A P81H [cytosol] (R-HSA-9632293) p16INK4A D84A [cytosol] (R-HSA-9632486) p16INK4A P81R [cytosol] (R-HSA-9632294)	0.61	8
UniProt:Q5FWF4 ZRAB3			0.599	8
UniProt:P24385 CCND1	4	CCND1 [nucleoplasm] (R-HSA-113832) CCND1 [cytosol] (R-HSA-68328) p-T286-CCND1 [nucleoplasm] (R-HSA-75811) p-T286-CCND1 [cytosol] (R-HSA-75813)	0.59	2
UniProt:P24522 GADD45A	1	GADD45A [nucleoplasm] (R-HSA-3215139)	0.589	3
UniProt:Q9H063 MAF1	3	p-S60,S68,S75-MAF1 [cytosol] (R-HSA-8944455) MAF1 [cytosol] (R-HSA-8944460) MAF1 [nucleoplasm] (R-HSA-8944422)	0.581	4
UniProt:P30041 PRDX6	3	PRDX6 [extracellular region] (R-HSA-6806198) PRDX6 [azurophil granule lumen] (R-HSA-6798744) PRDX6 [cytosol] (R-HSA-3343670)	0.573	2
UniProt:P61769 B2M	11	B2M(21-119) [early endosome membrane] (R-HSA-182298) B2M(21-119) [Golgi membrane] (R-HSA-983403) B2M(21-119) [ER to Golgi transport vesicle membrane] (R-HSA-983378) B2M(21-119) [early endosome lumen] (R-HSA-1236827) B2M(21-119) [recycling endosome membrane] (R-HSA-8863880) B2M(21-119) [phagocytic vesicle membrane] (R-HSA-1236891) B2M(21-119) [tertiary granule lumen] (R-HSA-6800179) B2M(21-119) [extracellular region] (R-HSA-1302721) B2M(21-119) [specific granule lumen] (R-HSA-6806144) B2M(21-119) [endoplasmic reticulum lumen] (R-HSA-983063) B2M(21-119) [plasma membrane] (R-HSA-167743)	0.573	3
UniProt:P07355 ANXA2	4	ANXA2 [cytosol] (R-HSA-5263667) ANXA2 [external side of plasma membrane] (R-HSA-5336164) ANXA2 [extracellular region] (R-HSA-6806242) ANXA2 [azurophil granule lumen] (R-HSA-6798766)	0.573	2
UniProt:P68104 EEF1A1	7	Me3K79-EEF1A1 [cytosol] (R-HSA-8932212) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022)	0.573	2
UniProt:P00558 PGK1	1	PGK1 [cytosol] (R-HSA-70483)	0.573	2
UniProt:P04075 ALDOA	6	ALDOA [platelet alpha granule lumen] (R-HSA-349738) ALDOA [tertiary granule lumen] (R-HSA-6801485) ALDOA [secretory granule lumen] (R-HSA-6801469) ALDOA [extracellular region] (R-HSA-349735) ALDOA [ficolin-1-rich granule lumen] (R-HSA-6801521) ALDOA [cytosol] (R-HSA-71492)	0.571	3
UniProt:P06733 ENO1	1	ENO1 [cytosol] (R-HSA-71437)	0.571	3
UniProt:P04406 GAPDH	1	GAPDH [cytosol] (R-HSA-70428)	0.571	3
UniProt:Q14527 HLTF	1	HLTF [nucleoplasm] (R-HSA-8855007)	0.564	2
UniProt:P61970 NTF2			0.556	3
UniProt:Q9NZD8 SPG21			0.556	3
UniProt:Q96DZ9-2 CMTM5			0.556	3
UniProt:Q8IWU4 SLC30A8	2	SLC30A8 [Golgi membrane] (R-HSA-9817561) SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:P03129 VE7			0.547	2
UniProt:A8CG34 POM121C	1	POM121C [nuclear envelope] (R-HSA-6805165)	0.547	2
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.547	2
UniProt:P18669 PGAM1	4	PGAM1 [cytosol] (R-HSA-71442) PGAM1 [ficolin-1-rich granule lumen] (R-HSA-6803309) PGAM1 [extracellular region] (R-HSA-6806482) PGAM1 [secretory granule lumen] (R-HSA-6803293)	0.544	2
UniProt:P60174 TPI1	1	TPI1 [cytosol] (R-HSA-70451)	0.544	2
UniProt:Q9H160 ING2	2	monoSUMO1-K195-ING2 [nucleoplasm] (R-HSA-4086075) ING2 [nucleoplasm] (R-HSA-3215167)	0.544	3
UniProt:P03950 ANG	2	ANG [cytosol] (R-HSA-9708345) ANG [extracellular region] (R-HSA-5692435)	0.537	4
UniProt:P35249 RFC4	1	RFC4 [nucleoplasm] (R-HSA-68429)	0.527	2
UniProt:P24864 CCNE1	3	CCNE1 [nucleoplasm] (R-HSA-68363) CCNE1 [cytosol] (R-HSA-157443) Unfolded CCNE1 [cytosol] (R-HSA-6813836)	0.527	3
UniProt:P35250 RFC2	1	RFC2 [nucleoplasm] (R-HSA-68433)	0.527	2
UniProt:O96020 CCNE2	3	Unfolded CCNE2 [cytosol] (R-HSA-6813844) CCNE2 [cytosol] (R-HSA-157452) CCNE2 [nucleoplasm] (R-HSA-68367)	0.527	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P14635 CCNB1	4	CCNB1 [nucleoplasm] (R-HSA-68901) p-4S-CCNB1 [cytosol] (R-HSA-170058) p-4S-CCNB1 [nucleoplasm] (R-HSA-170049) CCNB1 [cytosol] (R-HSA-157451)	0.527	3
UniProt:P20248 CCNA2	3	PolyUb-CCNA2 [nucleoplasm] (R-HSA-6783099) CCNA2 [cytosol] (R-HSA-157444) CCNA2 [nucleoplasm] (R-HSA-68905)	0.527	3
UniProt:P52701 MSH6	2	MSH6 L222* [nucleoplasm] (R-HSA-5632954) MSH6 [nucleoplasm] (R-HSA-5357528)	0.527	2
UniProt:Q9HCU8 POLD4	1	POLD4 [nucleoplasm] (R-HSA-68447)	0.524	4
UniProt:B4URF7 B4URF7			0.508	2
UniProt:Q9UBF6 RNF7	1	RNF7 (RBX2) [cytosol] (R-HSA-8863132)	0.508	3
UniProt:Q86TU7 SETD3	1	SETD3 [nucleoplasm] (R-HSA-5688411)	0.508	3
UniProt:Q1K9H5 Q1K9H5			0.508	2
UniProt:Q9H211 CDT1	1	CDT1 [nucleoplasm] (R-HSA-68536)	0.499	2
UniProt:Q8TE30 Q8TE30			0.499	6
UniProt:P57081 WDR4	1	WDR4 [nucleoplasm] (R-HSA-6782341)	0.462	3

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