Reactome | SDHB [mitochondrial inner membrane]

SDHB [mitochondrial inner membrane]

Stable Identifier

R-HSA-70985

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

Succinate Dehydrogenase complex subunit B, Succinate dehydrogenase (ubiquinone) iron-sulfur protein, mitochondrial, Ip, Iron-sulfur subunit of complex II

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Pyruvate metabolism and Citric Acid (TCA) cycle (Homo sapiens)
    - Citric acid cycle (TCA cycle) (Homo sapiens)
      - Succinate <=> Fumarate (with FAD redox reaction on enzyme) (Homo sapiens)
        
        SDH complex (ox.) [mitochondrial inner membrane] (Homo sapiens)
        
        Succinate dehydrogenase Iron Sulphur (subunit B) [mitochondrial inner membrane] (Homo sapiens)
        
        SDHB [mitochondrial inner membrane] (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Respiratory electron transport (Homo sapiens)
      - Transfer of electrons through the succinate dehydrogenase complex (Homo sapiens)
        
        SDH complex (ox.) [mitochondrial inner membrane] (Homo sapiens)
        
        Succinate dehydrogenase Iron Sulphur (subunit B) [mitochondrial inner membrane] (Homo sapiens)
        
        SDHB [mitochondrial inner membrane] (Homo sapiens)
        
        Succinate dehydrogenase complex (reduced) [mitochondrial inner membrane] (Homo sapiens)
        
        Succinate dehydrogenase Iron Sulphur (subunit B) [mitochondrial inner membrane] (Homo sapiens)
        
        SDHB [mitochondrial inner membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P21912 SDHB

Gene Names

SDHB, SDH, SDH1

Chain

transit peptide:1-28, chain:29-280

Reference Genes

BioGPS Gene:6390 SDHB

COSMIC (genes):SDHB SDHB

CTD Gene:6390 SDHB

dbSNP Gene:6390 SDHB

ENSEMBL:ENSG00000117118 SDHB

HGNC:10681 SDHB

KEGG Gene (Homo sapiens):6390 SDHB

Monarch:6390 SDHB

NCBI Gene:6390 SDHB

OMIM:185470 SDHB

UCSC:P21912 SDHB

Reference Transcript

RefSeq:NM_003000.2 SDHB

Other Identifiers

0002350435

11720631_a_at

11720632_x_at

11745517_s_at

16682384

202675_3p_at

202675_PM_at

202675_at

2398790

2398791

2398798

2398801

2398807

2398808

2398812

2398813

2398818

35751_at

6390

7912928

A_23_P149649

GE60529

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005743

GO:0005749

GO:0005886

GO:0006091

GO:0006099

GO:0006105

GO:0006121

GO:0006810

GO:0008150

GO:0008177

GO:0009055

GO:0009058

GO:0009060

GO:0016020

GO:0016491

GO:0022904

GO:0031966

GO:0032991

GO:0034641

GO:0042776

GO:0043167

GO:0043226

GO:0044281

GO:0045273

GO:0046872

GO:0048039

GO:0051536

GO:0051537

GO:0051538

GO:0051539

GO:0055085

HMNXSV003041951

Hs.64.1.S1_3p_s_at

ILMN_1667257

PH_hs_0000010

TC01002286.hg

U17886_at

g9257241_3p_s_at

Participates

as a component of

Succinate dehydrogenase Iron Sulphur (subunit B) [mitochondrial inner membrane] (Homo sapiens)

Inferred To

sdhb-1 [mitochondrial inner membrane] (Caenorhabditis elegans)

Sdhb [mitochondrial inner membrane] (Mus musculus)

Sdhb [mitochondrial inner membrane] (Rattus norvegicus)

sdhB [mitochondrial inner membrane] (Dictyostelium discoideum)

sdh2 [mitochondrial inner membrane] (Schizosaccharomyces pombe)

SDHB [mitochondrial inner membrane] (Bos taurus)

SDHB [mitochondrial inner membrane] (Canis familiaris)

SDHB [mitochondrial inner membrane] (Gallus gallus)

SDHB [mitochondrial inner membrane] (Sus scrofa)

SdhB [mitochondrial inner membrane] (Drosophila melanogaster)

sdhb [mitochondrial inner membrane] (Danio rerio)

sdhb [mitochondrial inner membrane] (Xenopus tropicalis)

SDH2 [mitochondrial inner membrane] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_002991.2

OpenTargets

ENSG00000117118

GeneCards

P21912

HPA

ENSG00000117118-SDHB

Ensembl

ENSG00000117118, ENSP00000364649, ENST00000375499

PRO

P21912

Pharos - Targets

P21912

Orphanet

15262

HMDB Protein

HMDBP00193

PDB

7KCL, 7KCM

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IWL3 HSCB	5	HSCB [mitochondrial matrix] (R-HSA-1299438) HSCB [mitochondrial inner membrane] (R-HSA-1299447) HSCB(1-235) [mitochondrial inner membrane] (R-HSA-1299443) HSCB(1-30) [mitochondrial matrix] (R-HSA-8986120) HSCB(1-235) [mitochondrial intermembrane space] (R-HSA-1299456)	0.813	21
UniProt:P38646 HSPA9	6	HSPA9 [nucleoplasm] (R-HSA-5252128) HSPA9 [cytosol] (R-HSA-5251993) HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968) HSPA9 [mitochondrial inner membrane] (R-HSA-1252206) HSPA9(1-679) [cytosol] (R-HSA-1267964)	0.662	10
UniProt:Q9H1K1 ISCU	1	ISCU [cytosol] (R-HSA-9771680)	0.623	7