Reactome | FAD-SDHA [mitochondrial matrix]

FAD-SDHA [mitochondrial matrix]

Stable Identifier

R-HSA-70983

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Succinate Dehydrogenase complex subunit A, Succinate dehydrogenase (ubiquinone) flavoprotein subunit, mitochondrial, Fp, Flavoprotein subunit of complex II

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
32887801	The roles of SDHAF2 and dicarboxylate in covalent flavinylation of SDHA, the human complex II flavoprotein Sharma, P, Iverson, TM, Cecchini, G, Maklashina, E	Proc Natl Acad Sci U S A	2020

External Reference Information

External Reference

UniProt:P31040 SDHA

Gene Names

SDHA, SDH2, SDHF

Chain

transit peptide:1-42, chain:43-664

Reference Genes

BioGPS Gene:6389 SDHA

COSMIC (genes):SDHA SDHA

CTD Gene:6389 SDHA

dbSNP Gene:6389 SDHA

ENSEMBL:ENSG00000073578 SDHA

ENSEMBL_homo_sapiens_GENE:ENSG00000073578.18 SDHA

HGNC:10680 SDHA

KEGG Gene (Homo sapiens):6389 SDHA

Monarch:6389 SDHA

NCBI Gene:6389 SDHA

OMIM:600857 SDHA

UCSC:P31040 SDHA

Reference Transcript

Other Identifiers

11744078_s_at

11747729_s_at

11747868_x_at

11749757_x_at

201093_PM_x_at

201093_x_at

222021_3p_x_at

222021_PM_x_at

222021_x_at

2659048

2659053

2659062

2659063

2659065

2659087

2659090

2659092

2712552

2712554

2712556

2712558

2712563

2712573

2712574

2712575

2712576

2712577

2712582

2712586

2712589

2713507

2713513

2713525

2798540

2798541

2798543

2798544

2798546

2798547

2798548

2798550

2798553

2798554

2798555

2798556

2798559

2798560

2798565

2798566

2798567

2798571

2798575

2798576

2798577

2846060

2846061

2846064

2846066

2846069

2846070

2846088

34826_at

6389

8084912

8093039

8104166

GO:0000104

GO:0003824

GO:0005515

GO:0005634

GO:0005730

GO:0005739

GO:0005743

GO:0005749

GO:0006091

GO:0006099

GO:0006105

GO:0006121

GO:0007399

GO:0008177

GO:0009055

GO:0016020

GO:0016491

GO:0016627

GO:0022900

GO:0022904

GO:0042776

GO:0043226

GO:0045257

GO:0048856

GO:0050660

GO:0055086

GO:0102040

GO:1901135

HMNXSV003018881

HMNXSV003039244

HMNXSV003052645

Hs.469.2.S1_3p_s_at

ILMN_1651664

ILMN_1734640

ILMN_1744210

L21936_at

g4759079_3p_s_at

Participates

as an output of

FAD attaches to SDHA (Homo sapiens)

as an input of

SDHAF4 binds to FAD-SDHA (Homo sapiens)

as a component of

Other forms of this molecule

SDHA [mitochondrial matrix]

Inferred To

FAD-SDHA [mitochondrial matrix] (Caenorhabditis elegans)

FAD-SDHA [mitochondrial matrix] (Danio rerio)

FAD-SDHA [mitochondrial matrix] (Dictyostelium discoideum)

FAD-SDHA [mitochondrial matrix] (Drosophila melanogaster)

FAD-SDHA [mitochondrial matrix] (Gallus gallus)

FAD-SDHA [mitochondrial matrix] (Mus musculus)

FAD-SDHA [mitochondrial matrix] (Plasmodium falciparum)

FAD-SDHA [mitochondrial matrix] (Rattus norvegicus)

FAD-SDHA [mitochondrial matrix] (Saccharomyces cerevisiae)

FAD-SDHA [mitochondrial matrix] (Schizosaccharomyces pombe)

FAD-SDHA [mitochondrial matrix] (Sus scrofa)

FAD-SDHA [mitochondrial matrix] (Xenopus tropicalis)

SDHA [mitochondrial matrix] (Bos taurus)

SDHA [mitochondrial matrix] (Canis familiaris)

Modified Residues

Name

1'-(8alpha-FAD)-L-histidine at 99

Coordinate

PsiMod Name

1'-(8alpha-FAD)-L-histidine

PsiMod Definition

A protein modification that effectively converts an L-histidine residue to 1'-(8alpha-FAD)-L-histidine.

Cross References

RefSeq

NP_001281261.1, NP_004159.2

OpenTargets

ENSG00000073578

GeneCards

P31040

HPA

ENSG00000073578-SDHA

Ensembl

ENST00000264932, ENSP00000427703, ENST00000510361, ENSP00000264932, ENSG00000073578

PRO

P31040

Pharos - Targets

P31040

Orphanet

15261

HMDB Protein

HMDBP00150

PDB

8DYD, 8DYE, 8GS8, 6VAX

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P21912 SDHB	2	SDHB [mitochondrial matrix] (R-HSA-9854983) SDHB [mitochondrial inner membrane] (R-HSA-70985)	0.823	11
UniProt:Q9NX18 SDHAF2	1	SDHAF2 [mitochondrial matrix] (R-HSA-9854689)	0.744	5
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.738	15
UniProt:P01889 HLA-B	8	class I MHC B7 [Golgi membrane] (R-HSA-983379) class I MHC B7 [ER to Golgi transport vesicle membrane] (R-HSA-983362) class I MHC B7 [early endosome membrane] (R-HSA-1236872) class I MHC B7 [recycling endosome membrane] (R-HSA-8863942) class I MHC B7 [phagocytic vesicle membrane] (R-HSA-1236753) class I MHC B7 [secretory granule membrane] (R-HSA-6804794) class I MHC B7 [plasma membrane] (R-HSA-167756) class I MHC B7 [lumenal side of endoplasmic reticulum membrane] (R-HSA-983073)	0.564	2
UniProt:Q9NTG7 SIRT3	2	SIRT3 [nucleoplasm] (R-HSA-9622879) SIRT3(?-399) [mitochondrial matrix] (R-HSA-1605416)	0.527	2
UniProt:Q5VUM1 SDHAF4	1	SDHAF4 [mitochondrial matrix] (R-HSA-9854972)	0.527	3
UniProt:Q9UPQ7 PZRN3			0.527	2
UniProt:Q9NRP4 SDHAF3	1	SDHAF3 [mitochondrial matrix] (R-HSA-9855015)	0.527	2
UniProt:Q9P0J1 PDP1	1	PDP1 [mitochondrial matrix] (R-HSA-204149)	0.527	2
UniProt:P05141 SLC25A5	1	SLC25A5 [mitochondrial inner membrane] (R-HSA-49743)	0.527	5
UniProt:Q86YH6 PDSS2	1	PDSS2 [mitochondrial matrix] (R-HSA-2162264)	0.527	2
UniProt:P26045 PTPN3	3	PTPN3 [plasma membrane] (R-HSA-5490317) p-S459 PTPN3 [cytosol] (R-HSA-8868111) PTPN3 [cytosol] (R-HSA-8867650)	0.499	2
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.462	2

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