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UBTF [nucleoplasm]
Stable Identifier
R-HSA-73683
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
UBF, Nucleolar transcription factor 1 (Upstream binding factor 1) (UBF-1) (Autoantigen NOR-90), Nucleolar transcription factor 1, Upstream binding factor 1, UBF-1, Autoantigen NOR-90
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
Epigenetic regulation of gene expression (Homo sapiens)
Negative epigenetic regulation of rRNA expression (Homo sapiens)
NoRC negatively regulates rRNA expression (Homo sapiens)
Transcription of intergenic spacer of the rRNA gene (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
UBTF [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription (Homo sapiens)
RNA Polymerase I Promoter Clearance (Homo sapiens)
RNA Polymerase I Promoter Escape (Homo sapiens)
Elongation of pre-rRNA transcript (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
UBTF [nucleoplasm] (Homo sapiens)
Loss of Rrn3 from RNA Polymerase I promoter escape complex (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
UBTF [nucleoplasm] (Homo sapiens)
RNA Polymerase I Promoter Opening (Homo sapiens)
Phosphorylation of UBF-1:rDNA Promoter (Homo sapiens)
UBF-1:rDNA Promoter [nucleoplasm] (Homo sapiens)
UBTF [nucleoplasm] (Homo sapiens)
UBF-1 Binds rDNA Promoter (Homo sapiens)
UBF-1:rDNA Promoter [nucleoplasm] (Homo sapiens)
UBTF [nucleoplasm] (Homo sapiens)
UBTF [nucleoplasm] (Homo sapiens)
RNA Polymerase I Transcription Termination (Homo sapiens)
Dissociation of PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box (Homo sapiens)
PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
UBTF [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
UBTF [nucleoplasm] (Homo sapiens)
PTRF Binds the Polymerase I Transcription Complex/Nascent Pre rRNA Complex paused at the TTF-I:Sal Box (Homo sapiens)
PTRF:Polymerase I/Nascent Pre rRNA Complex:TTF-I:Sal Box [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
UBTF [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
UBTF [nucleoplasm] (Homo sapiens)
Polymerase I Transcription Complex/Nascent Pre rRNA Complex pauses at the TTF-I:Sal Box (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
UBTF [nucleoplasm] (Homo sapiens)
RNA Polymerase I:rRNATranscript:TTF-1:Sal Box Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
UBTF [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17480 UBTF
Gene Names
UBTF, UBF, UBF1
Chain
chain:1-764
Reference Genes
BioGPS Gene:7343 UBTF
COSMIC (genes):UBTF UBTF
CTD Gene:7343 UBTF
dbSNP Gene:7343 UBTF
ENSEMBL:ENSG00000108312 UBTF
HGNC:12511 UBTF
Monarch:7343 UBTF
NCBI Gene:7343 UBTF
OMIM:600673 UBTF
UCSC:P17480 UBTF
Reference Transcript
RefSeq:XM_017025003.1 UBTF
RefSeq:NM_001076683.1 UBTF
RefSeq:NM_001076684.2 UBTF
RefSeq:XM_006722060.2 UBTF
RefSeq:XM_006722059.3 UBTF
RefSeq:NM_014233.3 UBTF
RefSeq:XM_006722061.2 UBTF
RefSeq:XM_017025004.1 UBTF
Other Identifiers
11722384_s_at
11722385_a_at
11748946_s_at
11748947_x_at
1558215_PM_s_at
1558215_s_at
16845589
202692_3p_s_at
202692_PM_s_at
202692_s_at
214881_PM_s_at
214881_s_at
225982_PM_at
225982_at
3758968
3758969
3758970
3758971
3758972
3758973
3758974
3758976
3758977
3758978
3758979
3758980
3758981
3758982
3758983
3758984
3758985
3758986
3758987
3758988
3758989
3758990
3758991
3758992
3758993
3758994
3758995
3758996
3758997
3758998
3758999
3759000
3759002
3759003
3759004
3759005
3759007
38794_at
38795_s_at
54853_at
7343
8015969
91449_at
A_23_P100779
A_24_P349616
GE59783
GE84858
GO:0001164
GO:0001165
GO:0001181
GO:0001188
GO:0001650
GO:0003677
GO:0003682
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0006351
GO:0006355
GO:0006360
GO:0006361
GO:0043226
GO:0043229
GO:0045943
GO:0065003
GO:0097110
GO:0140223
HMNXSV003002387
Hs.105097.1.A1_3p_at
Hs.105097.1.A1_3p_x_at
Hs.89781.1.A1_3p_a_at
Hs2.417554.1.A1_3p_s_at
ILMN_1806946
ILMN_1877756
ILMN_2287147
ILMN_2292334
ILMN_2394264
PH_hs_0005020
TC17001576.hg
TC17002655.hg
X53390_s_at
X56687_s_at
g7657670_3p_a_at
g7657670_3p_at
g7657670_3p_x_at
Participates
as an input of
UBF-1 Binds rDNA Promoter (Homo sapiens)
as a component of
UBF-1:rDNA Promoter [nucleoplasm] (Homo sapiens)
RNA Polymerase I promoter escape complex [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-UBTF [nucleoplasm]
Inferred To
Ubtf [nucleoplasm]
(Mus musculus)
Ubtf [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of UBTF [nucleoplasm]
(Caenorhabditis elegans)
Ghost homologue of UBTF [nucleoplasm]
(Dictyostelium discoideum)
Ghost homologue of UBTF [nucleoplasm]
(Drosophila melanogaster)
Ghost homologue of UBTF [nucleoplasm]
(Saccharomyces cerevisiae)
Ghost homologue of UBTF [nucleoplasm]
(Schizosaccharomyces pombe)
UBTF [nucleoplasm]
(Bos taurus)
UBTF [nucleoplasm]
(Canis familiaris)
UBTF [nucleoplasm]
(Gallus gallus)
UBTF [nucleoplasm]
(Sus scrofa)
ubtf [nucleoplasm]
(Danio rerio)
ubtf [nucleoplasm]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000108312
ENSEMBL
ENST00000704741
,
ENST00000704746
,
ENST00000704742
,
ENST00000533177
,
ENST00000526094
,
ENSP00000377231
,
ENST00000529383
,
ENST00000343638
,
ENST00000302904
,
ENSP00000345297
,
ENSP00000302640
,
ENSP00000516020
,
ENST00000393606
,
ENSP00000432925
,
ENSP00000516019
,
ENSP00000516023
,
ENSP00000435708
,
ENSP00000390669
,
ENST00000436088
,
ENSP00000437180
HPA
ENSG00000108312-UBTF
PRO
P17480
Pharos - Targets
P17480
Orphanet
UBTF
GlyGen
P17480
PDB
2HDZ
,
1L8Y
,
1L8Z
,
1K99
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q01105 SET
1
SET [nucleoplasm]
(R-HSA-451201)
0.639
4
UniProt:P01106 MYC
2
MYC [nucleoplasm]
(R-HSA-188379)
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
0.564
2
UniProt:Q13950 RUNX2
0.564
4
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.462
2
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