Reactome | PDIA3 [endoplasmic reticulum lumen]

PDIA3 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-901028

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

ERp57, Protein disulfide-isomerase A3, PDIA3_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P30101 PDIA3

Gene Names

PDIA3, ERP57, ERP60, GRP58

Chain

signal peptide:1-24, chain:25-505

Reference Genes

BioGPS Gene:2923 PDIA3

COSMIC (genes):PDIA3 PDIA3

CTD Gene:2923 PDIA3

dbSNP Gene:2923 PDIA3

ENSEMBL:ENSG00000167004 PDIA3

ENSEMBL_homo_sapiens_GENE:ENSG00000167004.14 PDIA3

HGNC:4606 PDIA3

KEGG Gene (Homo sapiens):2923 PDIA3

Monarch:2923 PDIA3

NCBI Gene:2923 PDIA3

OMIM:602046 PDIA3

Reference Transcript

RefSeq:NM_005313.4 PDIA3

Other Identifiers

11743440_at

11743441_s_at

208612_PM_at

208612_at

227033_PM_at

227033_at

229453_PM_at

229453_at

2356689

2923

3591553

3591612

3591613

3591614

3591621

3591626

3591628

3591630

3591631

3591632

3591634

3591636

3591637

3591638

3591640

3591641

3591642

3591643

3591645

3591647

38986_at

48098_at

57668_s_at

74821_s_at

7904881

7983274

A_14_P119353

A_33_P3223923

GE57097

GO:0002250

GO:0002376

GO:0002502

GO:0003723

GO:0003756

GO:0003824

GO:0004197

GO:0004629

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005768

GO:0005783

GO:0005788

GO:0005925

GO:0006457

GO:0007155

GO:0009986

GO:0012501

GO:0015035

GO:0015036

GO:0016491

GO:0016787

GO:0016853

GO:0023052

GO:0031410

GO:0034975

GO:0034976

GO:0042060

GO:0042470

GO:0042802

GO:0042824

GO:0043226

GO:0045335

GO:0055038

GO:0061779

GO:0065003

GO:0070062

GO:0070527

GO:0097191

GO:0098761

GO:0140096

GO:2001238

Hs.289101.1.A1_3p_at

Hs.296178.1.A1_3p_at

ILMN_1669753

PH_hs_0023683

PH_hs_0032616

TC15000335.hg

Z49835_s_at

g1208426_3p_at

Participates

as a component of

as an input of

as an output of

Other forms of this molecule

PDIA3 [phagocytic vesicle]

PDIA3 [recycling endosome membrane]

Inferred To

PDIA3 [endoplasmic reticulum lumen] (Bos taurus)

PDIA3 [endoplasmic reticulum lumen] (Canis familiaris)

PDIA3 [endoplasmic reticulum lumen] (Gallus gallus)

PDIA3 [endoplasmic reticulum lumen] (Plasmodium falciparum)

PDIA3 [endoplasmic reticulum lumen] (Schizosaccharomyces pombe)

PDIA3 [endoplasmic reticulum lumen] (Sus scrofa)

pdia3 [endoplasmic reticulum lumen] (Xenopus tropicalis)

pdi-3 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

pdia7 [endoplasmic reticulum lumen] (Danio rerio)

PDI1 [endoplasmic reticulum lumen] (Saccharomyces cerevisiae)

pdi2 [endoplasmic reticulum lumen] (Dictyostelium discoideum)

Erp57 [endoplasmic reticulum lumen] (Mus musculus)

pdia8 [endoplasmic reticulum lumen] (Danio rerio)

ERp60 [endoplasmic reticulum lumen] (Drosophila melanogaster)

Pdia3 [endoplasmic reticulum lumen] (Rattus norvegicus)

Homologues of PDIA3 [endoplasmic reticulum lumen] (Danio rerio)

Homologues of PDIA3 [endoplasmic reticulum lumen] (Plasmodium falciparum)

Cross References

RefSeq

NP_005304.3

OpenTargets

ENSG00000167004

IntEnz

5.3.4.1

HPA

ENSG00000167004-PDIA3

GeneCards

P30101

Ensembl

ENSG00000167004, ENSP00000300289, ENST00000300289

PRO

P30101

Pharos - Targets

P30101

PDB

2ALB, 6ENY, 2DMM, 7QNG, 3F8U, 2H8L, 7QPD

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.725	12
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.703	6
UniProt:Q96HE7 ERO1A	1	ERO1L [endoplasmic reticulum lumen] (R-HSA-265076)	0.667	3
UniProt:Q03518 TAP1	3	TAP1 [phagocytic vesicle membrane] (R-HSA-1236845) TAP1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863953) TAP1 [endoplasmic reticulum membrane] (R-HSA-947474)	0.623	5
UniProt:P10909 CLU	4	CLU(23-449) [extracellular region] (R-HSA-349732) CLU(23-449) [platelet alpha granule lumen] (R-HSA-349733) CLU(228-449) [extracellular region] (R-HSA-6810626) CLU(23-227) [extracellular region] (R-HSA-6810660)	0.59	2
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.589	2
UniProt:P24643 CALX			0.558	3
UniProt:Q13586 STIM1	1	STIM1 [endoplasmic reticulum membrane] (R-HSA-434675)	0.543	3
UniProt:P05111 INHA	1	INHA [extracellular region] (R-HSA-1449702)	0.527	2
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	2
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.499	2
UniProt:Q2HXL6 EDEM3			0.462	2
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	2

Cite Us!