Reactome | CLU(23-449) [platelet alpha granule lumen]

CLU(23-449) [platelet alpha granule lumen]

Stable Identifier

R-HSA-349733

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

platelet alpha granule lumen

Synonyms

Clusterin, CLU

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P10909 CLU

Gene Names

CLU, APOJ, CLI, KUB1, AAG4

Chain

signal peptide:1-22, chain:23-449, chain:23-227, chain:228-449

Reference Genes

BioGPS Gene:1191 CLU

COSMIC (genes):CLU CLU

CTD Gene:1191 CLU

dbSNP Gene:1191 CLU

ENSEMBL:ENSG00000120885 CLU

ENSEMBL_homo_sapiens_GENE:ENSG00000120885.22 CLU

HGNC:2095 CLU

KEGG Gene (Homo sapiens):1191 CLU

Monarch:1191 CLU

NCBI Gene:1191 CLU

OMIM:185430 CLU

UCSC:P10909 CLU

Reference Transcript

RefSeq:NM_001831.3 CLU

Other Identifiers

11715851_s_at

11756547_a_at

1191

17075731

208791_PM_at

208791_at

208792_PM_s_at

208792_s_at

222043_PM_at

222043_at

3129071

3129072

3129073

3129074

3129075

3129076

3129077

3129078

3129079

3129081

3129083

3129085

3129086

3129087

3129088

3129089

3129090

3129092

3129093

3129096

3129097

3129098

3129099

3129100

3129101

3129102

3129103

3129104

3129105

3129109

36780_at

43817_f_at

63969_f_at

75382_i_at

75384_f_at

80587_s_at

8149927

A_23_P215913

GE479016

GE61669

GE79935

GO:0000902

GO:0001540

GO:0001774

GO:0001836

GO:0002376

GO:0002434

GO:0005102

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005739

GO:0005743

GO:0005783

GO:0005794

GO:0005829

GO:0005856

GO:0006351

GO:0006355

GO:0006457

GO:0006629

GO:0006886

GO:0006914

GO:0006915

GO:0006954

GO:0006956

GO:0006958

GO:0007005

GO:0008092

GO:0009615

GO:0009986

GO:0010628

GO:0012501

GO:0016020

GO:0016192

GO:0017038

GO:0023052

GO:0030154

GO:0030163

GO:0030312

GO:0031012

GO:0031093

GO:0031333

GO:0031334

GO:0031410

GO:0031625

GO:0031966

GO:0032286

GO:0032436

GO:0032760

GO:0032991

GO:0034366

GO:0042127

GO:0042583

GO:0042981

GO:0043065

GO:0043226

GO:0043231

GO:0043524

GO:0043691

GO:0044877

GO:0045087

GO:0045202

GO:0045429

GO:0048156

GO:0048260

GO:0048471

GO:0048856

GO:0050750

GO:0050821

GO:0051082

GO:0051087

GO:0051092

GO:0051131

GO:0051787

GO:0051788

GO:0061024

GO:0061077

GO:0061518

GO:0061740

GO:0062023

GO:0065003

GO:0070062

GO:0071944

GO:0072562

GO:0090201

GO:0097418

GO:0097440

GO:0098542

GO:0099020

GO:0140104

GO:0140597

GO:1900221

GO:1902004

GO:1902230

GO:1902430

GO:1902847

GO:1902998

GO:1903573

GO:1905907

GO:1905908

GO:2000060

HMNXSV003026147

HMNXSV003030892

Hs.75106.1.S1_3p_at

ILMN_1691483

ILMN_1798298

M63379_at

PH_hs_0025525

TC08001081.hg

TC08002263.hg

g180619_3p_a_at

g180619_3p_at

Participates

as a member of

Platelet alpha granule contents [platelet alpha granule lumen] (Homo sapiens)

Other forms of this molecule

CLU(23-449) [extracellular region]

CLU(228-449) [extracellular region]

CLU(23-227) [extracellular region]

Inferred To

CLU [platelet alpha granule lumen] (Bos taurus)

CLU [platelet alpha granule lumen] (Canis familiaris)

CLU [platelet alpha granule lumen] (Sus scrofa)

Homologues of CLU(23-449) [platelet alpha granule lumen] (Sus scrofa)

clu [platelet alpha granule lumen] (Danio rerio)

clu [platelet alpha granule lumen] (Xenopus tropicalis)

Clu [platelet alpha granule lumen] (Mus musculus)

Clu [platelet alpha granule lumen] (Rattus norvegicus)

Cross References

RefSeq

NP_001822.3

Guide to Pharmacology - Targets

3195

OpenTargets

ENSG00000120885

GeneCards

P10909

HPA

ENSG00000120885-CLU

Ensembl

ENSG00000120885, ENSP00000429620, ENSP00000315130, ENST00000523500, ENST00000316403, ENST00000405140, ENSP00000385419

PRO

P10909

Pharos - Targets

P10909

PDB

7ZEU, 7ZET

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.662	4
UniProt:P30101 PDIA3	3	PDIA3 [phagocytic vesicle] (R-HSA-1236870) PDIA3 [recycling endosome membrane] (R-HSA-8863849) PDIA3 [endoplasmic reticulum lumen] (R-HSA-901028)	0.59	2
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3
UniProt:P18509 ADCYAP1	4	ADCYAP1(132-158) [extracellular region] (R-HSA-420144) ADCYAP1(82-129) [extracellular region] (R-HSA-420254) ADCYAP1(132-169) [extracellular region] (R-HSA-420282) ADCYAP1(2-742) [Golgi membrane] (R-HSA-187679)	0.543	4
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.527	2
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.524	2
UniProt:P37231 PPARG	2	monoSUMO1-K107,K395-PPARG [nucleoplasm] (R-HSA-4717444) PPARG [nucleoplasm] (R-HSA-446172)	0.524	3