RHOU GTPase cycle

Stable Identifier
Homo sapiens
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RHO GTPase RHOU (Wrch-1) possesses a high intrinsic guanine nucleotide exchange activity and is constitutively present in the active GTP-bound state in the absence of guanine nucleotide exchange factors (GEFs) (Shutes et al. 2004, Saras et al. 2004). RHOU does not possess a GTPase activity (Saras et al. 2004). RHOU has been reported to interact with some GTPase activator proteins (GAPs) (Bagci et al. 2020), which may serve as effectors that enable cross-talk with other RHO GTPases. RHOU was shown to regulate cytoskeletal dynamics, cell migration and adhesion. RHOU is expressed during embryonic development and regulates cardiac (Dickover et al. 2014) and intestinal (Slaymi et al. 2019) development. RHOU activates JNK and AKT signaling during cell migration (Chuang et al. 2007).
For review, please refer to Faure and Fort 2015, and Hodge and Ridley 2020.

Literature References
PubMed ID Title Journal Year
26555387 Atypical RhoV and RhoU GTPases control development of the neural crest

Fort, P, Faure, S

Small GTPases 2015
30834544 The atypical RhoU/Wrch1 Rho GTPase controls cell proliferation and apoptosis in the gut epithelium

Fort, P, Raynaud, P, Roux, P, Cres, G, Vignal, E, Blangy, A, Slaymi, C

Biol Cell 2019
17504809 The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration

Valster, A, Chuang, YY, Coniglio, SJ, Symons, M, Backer, JM

J Cell Sci 2007
29189096 Regulation and functions of RhoU and RhoV

Ridley, AJ, Hodge, RG

Small GTPases 2020
15556869 Atypical mechanism of regulation of the Wrch-1 Rho family small GTPase

Der, CJ, Shutes, A, Cox, AD, Berzat, AC

Curr. Biol. 2004
18086875 The atypical Rho GTPase Wrch1 collaborates with the nonreceptor tyrosine kinases Pyk2 and Src in regulating cytoskeletal dynamics

Ruusala, A, Aspenström, P

Mol Cell Biol 2008
24607366 The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis

Hegarty, JM, Tedeschi, N, Lopez, D, Zhang, R, Yang, H, Chi, NC, Ly, K, Dickover, M, Hsiai, TK

Dev Biol 2014
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