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p-6S-NCF1 [cytosol]
Stable Identifier
R-HSA-9626854
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p-6S-p47phox, Neutrophil cytosol factor 1, NCF1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase Effectors (Homo sapiens)
RHO GTPases Activate NADPH Oxidases (Homo sapiens)
PKC phosphorylates NCF1 (Homo sapiens)
PIN1:p-S-6S-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
p-6S-NCF1 [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
8089108
The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases
Faust, LP
,
el Benna, J
,
Babior, BM
J Biol Chem
1994
External Reference Information
External Reference
UniProt:P14598 NCF1
Gene Names
NCF1, NOXO2, SH3PXD1A
Chain
chain:1-390
Reference Genes
BioGPS Gene:653361 NCF1
COSMIC (genes):NCF1 NCF1
CTD Gene:653361 NCF1
dbSNP Gene:653361 NCF1
ENSEMBL:ENSG00000158517 NCF1
HGNC:7660 NCF1
KEGG Gene (Homo sapiens):653361 NCF1
Monarch:653361 NCF1
NCBI Gene:653361 NCF1
OMIM:608512 NCF1
UCSC:P14598 NCF1
Reference Transcript
RefSeq:NM_000265.5 NCF1
Other Identifiers
0005900519
11746014_s_at
204961_3p_s_at
204961_s_at
214084_3p_x_at
214084_x_at
3007741
3007742
3007745
3007746
3007747
3007749
3007751
3007753
3007754
3007755
3007758
3007760
3007761
3007762
3007763
3007764
3007765
3007766
3008477
3008478
3008479
3008481
3008482
3008484
3008485
3008487
3008488
3008489
3008491
3008494
3008495
3008496
3008497
3008498
3008499
3056906
3056907
3056908
3056909
3056910
3056911
3056913
3056917
3056918
3056920
3056922
3056924
3056925
3056926
3056930
3056931
40159_r_at
653361
8133314
8133518
8140227
A_32_P116203
A_33_P3211432
A_33_P3224803
A_33_P3369393
GE57968
GO:0002376
GO:0002479
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005764
GO:0005773
GO:0005783
GO:0005791
GO:0005794
GO:0005829
GO:0005886
GO:0006091
GO:0006464
GO:0006605
GO:0006612
GO:0006801
GO:0006810
GO:0006915
GO:0006950
GO:0006968
GO:0007165
GO:0008150
GO:0008219
GO:0008289
GO:0009055
GO:0009058
GO:0014068
GO:0015031
GO:0016020
GO:0016175
GO:0016176
GO:0016491
GO:0017124
GO:0019898
GO:0022900
GO:0030234
GO:0030425
GO:0031410
GO:0032010
GO:0032991
GO:0034599
GO:0034614
GO:0034641
GO:0035091
GO:0042554
GO:0042592
GO:0043020
GO:0043025
GO:0043167
GO:0043226
GO:0043325
GO:0045087
GO:0045454
GO:0045730
GO:0045741
GO:0045893
GO:0046330
GO:0048010
GO:0060090
GO:0071276
GO:1900745
HMNXSV003039349
HMNXSV003055897
HMNXSV003058199
Hs.1583.1.S1_3p_at
Hs.1583.1.S1_3p_s_at
Hs.1583.1.S1_3p_x_at
ILMN_1697309
M55067_at
PH_hs_0035298
TC07000438.hg
TC07000459.hg
TC07001516.hg
TC07002399.hg
TC07003026.hg
g4557784_3p_a_at
g4557784_3p_s_at
g4557784_3p_x_at
Participates
as a component of
PIN1:p-S-6S-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
Other forms of this molecule
NCF1 [cytosol]
p-6S-NCF1 [phagolysosome]
p-S345-NCF1 [cytosol]
Inferred To
phospho-Ncf1 [cytosol]
(Mus musculus)
phospho-Ncf1 [cytosol]
(Rattus norvegicus)
phospho-NCF1C [cytosol]
(Gallus gallus)
phospho-BEM1 [cytosol]
(Saccharomyces cerevisiae)
phospho-scd2 [cytosol]
(Schizosaccharomyces pombe)
phospho-ncf1 [cytosol]
(Danio rerio)
phospho-ncf1 [cytosol]
(Xenopus tropicalis)
Ghost homologue of p-6S-NCF1 [cytosol]
(Canis familiaris)
phospho-NCF1 [cytosol]
(Bos taurus)
phospho-NCF1 [cytosol]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at 303
Coordinate
303
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 304
Coordinate
304
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 320
Coordinate
320
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 328
Coordinate
328
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 345
Coordinate
345
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 348
Coordinate
348
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_000256.4
OpenTargets
ENSG00000158517
HPA
ENSG00000158517-NCF1
GeneCards
P14598
Ensembl
ENSG00000158517
,
ENST00000289473
,
ENSP00000289473
PRO
P14598
Pharos - Targets
P14598
Orphanet
16519
HMDB Protein
HMDBP02126
PDB
1GD5
,
1KQ6
,
1NG2
,
1WLP
,
1K4U
,
1O7K
,
1UEC
,
1W70
,
1OV3
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q04206 RELA
6
polySUMO3-K37,K122,K123-RELA [nucleoplasm]
(R-HSA-4755466)
MeK310-RELA [nucleoplasm]
(R-HSA-8865233)
p-S276,5xAcK-RELA [nucleoplasm]
(R-HSA-5660642)
p-S276-RELA [nucleoplasm]
(R-HSA-5624468)
RELA [cytosol]
(R-HSA-168172)
RELA [nucleoplasm]
(R-HSA-177676)
0.682
8
UniProt:P60709 ACTB
5
Unfolded ACTB [cytosol]
(R-HSA-390462)
ACTB(1-375) [nucleoplasm]
(R-HSA-3321990)
ACTB(1-375) [lysosomal membrane]
(R-HSA-196160)
ACTB(1-375) [cytosol]
(R-HSA-201861)
ACTB(1-375) [plasma membrane]
(R-HSA-196016)
0.558
3
UniProt:P78325 ADAM8
4
ADAM8 [ficolin-1-rich granule membrane]
(R-HSA-6801017)
ADAM8 [tertiary granule membrane]
(R-HSA-6800884)
ADAM8 [plasma membrane]
(R-HSA-708331)
ADAM8 [specific granule membrane]
(R-HSA-6799563)
0.558
2
UniProt:Q05513 PRKCZ
5
pS, p-T410-PRKCZ [cytosol]
(R-HSA-9632824)
PRKCZ [cytosol]
(R-HSA-58218)
PRKCZ [cell junction]
(R-HSA-2134483)
p-T410-PRKCZ [cytosol]
(R-HSA-437181)
p-T410,T563-PRKCZ [cytosol]
(R-HSA-5218698)
0.556
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.499
2
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