Reactome | p-6S-NCF1 [cytosol]

p-6S-NCF1 [cytosol]

Stable Identifier

R-HSA-9626854

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-6S-p47phox, Neutrophil cytosol factor 1, NCF1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate NADPH Oxidases (Homo sapiens)
        
        PKC phosphorylates NCF1 (Homo sapiens)
        
        PIN1:p-S-6S-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)
        
        p-6S-NCF1 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
8089108	The phosphorylation of the respiratory burst oxidase component p47phox during neutrophil activation. Phosphorylation of sites recognized by protein kinase C and by proline-directed kinases Faust, LP, el Benna, J, Babior, BM	J Biol Chem	1994

External Reference Information

External Reference

UniProt:P14598 NCF1

Gene Names

NCF1, NOXO2, SH3PXD1A

Chain

chain:1-390

Reference Genes

BioGPS Gene:653361 NCF1

COSMIC (genes):NCF1 NCF1

CTD Gene:653361 NCF1

dbSNP Gene:653361 NCF1

ENSEMBL:ENSG00000158517 NCF1

HGNC:7660 NCF1

KEGG Gene (Homo sapiens):653361 NCF1

Monarch:653361 NCF1

NCBI Gene:653361 NCF1

OMIM:608512 NCF1

UCSC:P14598 NCF1

Reference Transcript

RefSeq:NM_000265.5 NCF1

Other Identifiers

0005900519

11746014_s_at

204961_3p_s_at

204961_s_at

214084_3p_x_at

214084_x_at

3007741

3007742

3007745

3007746

3007747

3007749

3007751

3007753

3007754

3007755

3007758

3007760

3007761

3007762

3007763

3007764

3007765

3007766

3008477

3008478

3008479

3008481

3008482

3008484

3008485

3008487

3008488

3008489

3008491

3008494

3008495

3008496

3008497

3008498

3008499

3056906

3056907

3056908

3056909

3056910

3056911

3056913

3056917

3056918

3056920

3056922

3056924

3056925

3056926

3056930

3056931

40159_r_at

653361

8133314

8133518

8140227

A_32_P116203

A_33_P3211432

A_33_P3224803

A_33_P3369393

GE57968

GO:0002376

GO:0002479

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005764

GO:0005773

GO:0005783

GO:0005791

GO:0005794

GO:0005829

GO:0005886

GO:0006091

GO:0006464

GO:0006605

GO:0006612

GO:0006801

GO:0006810

GO:0006915

GO:0006950

GO:0006968

GO:0007165

GO:0008150

GO:0008219

GO:0008289

GO:0009055

GO:0009058

GO:0014068

GO:0015031

GO:0016020

GO:0016175

GO:0016176

GO:0016491

GO:0017124

GO:0019898

GO:0022900

GO:0030234

GO:0030425

GO:0031410

GO:0032010

GO:0032991

GO:0034599

GO:0034614

GO:0034641

GO:0035091

GO:0042554

GO:0042592

GO:0043020

GO:0043025

GO:0043167

GO:0043226

GO:0043325

GO:0045087

GO:0045454

GO:0045730

GO:0045741

GO:0045893

GO:0046330

GO:0048010

GO:0060090

GO:0071276

GO:1900745

HMNXSV003039349

HMNXSV003055897

HMNXSV003058199

Hs.1583.1.S1_3p_at

Hs.1583.1.S1_3p_s_at

Hs.1583.1.S1_3p_x_at

ILMN_1697309

M55067_at

PH_hs_0035298

TC07000438.hg

TC07000459.hg

TC07001516.hg

TC07002399.hg

TC07003026.hg

g4557784_3p_a_at

g4557784_3p_s_at

g4557784_3p_x_at

Participates

as a component of

PIN1:p-S-6S-NCF1:NCF2:NCF4 [cytosol] (Homo sapiens)

Other forms of this molecule

NCF1 [cytosol]

p-6S-NCF1 [phagolysosome]

p-S345-NCF1 [cytosol]

Inferred To

phospho-Ncf1 [cytosol] (Mus musculus)

phospho-Ncf1 [cytosol] (Rattus norvegicus)

phospho-NCF1C [cytosol] (Gallus gallus)

phospho-BEM1 [cytosol] (Saccharomyces cerevisiae)

phospho-scd2 [cytosol] (Schizosaccharomyces pombe)

phospho-ncf1 [cytosol] (Danio rerio)

phospho-ncf1 [cytosol] (Xenopus tropicalis)

Ghost homologue of p-6S-NCF1 [cytosol] (Canis familiaris)

phospho-NCF1 [cytosol] (Bos taurus)

phospho-NCF1 [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 303

Coordinate

303

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 304

Coordinate

304

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 320

Coordinate

320

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 328

Coordinate

328

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 345

Coordinate

345

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 348

Coordinate

348

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_000256.4

OpenTargets

ENSG00000158517

HPA

ENSG00000158517-NCF1

GeneCards

P14598

Ensembl

ENSG00000158517, ENST00000289473, ENSP00000289473

PRO

P14598

Pharos - Targets

P14598

Orphanet

16519

HMDB Protein

HMDBP02126

PDB

1GD5, 1KQ6, 1NG2, 1WLP, 1K4U, 1O7K, 1UEC, 1W70, 1OV3

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q04206 RELA	6	polySUMO3-K37,K122,K123-RELA [nucleoplasm] (R-HSA-4755466) MeK310-RELA [nucleoplasm] (R-HSA-8865233) p-S276,5xAcK-RELA [nucleoplasm] (R-HSA-5660642) p-S276-RELA [nucleoplasm] (R-HSA-5624468) RELA [cytosol] (R-HSA-168172) RELA [nucleoplasm] (R-HSA-177676)	0.682	8
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.558	3
UniProt:P78325 ADAM8	4	ADAM8 [ficolin-1-rich granule membrane] (R-HSA-6801017) ADAM8 [tertiary granule membrane] (R-HSA-6800884) ADAM8 [plasma membrane] (R-HSA-708331) ADAM8 [specific granule membrane] (R-HSA-6799563)	0.558	2
UniProt:Q05513 PRKCZ	5	pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cytosol] (R-HSA-58218) PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.499	2