PDGFRA D842Y [plasma membrane]

Stable Identifier
R-HSA-9671956
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Alpha platelet-derived growth factor receptor, PGDS_HUMAN
PDGFRA D842Y [plasma membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
15928335 PDGFRA mutations in gastrointestinal stromal tumors: frequency, spectrum and in vitro sensitivity to imatinib

Shiraga, S, McGreevey, L, Schroeder, A, Corless, CL, Heinrich, MC, Harrell, P, Morich, J, Bainbridge, T, Town, A, Griffith, D

J. Clin. Oncol. 2005
External Reference Information
External Reference
Gene Names
PDGFRA, PDGFR2, RHEPDGFRA
Chain
signal peptide:1-23, chain:24-1089
Other Identifiers
11743850_at
11750772_a_at
11760753_a_at
11762023_at
1554828_PM_at
1554828_at
16966809
1731_at
1968_g_at
1987_at
203131_PM_at
203131_at
215305_PM_at
215305_at
2727350
2727370
2727372
2727373
2727374
2727375
2727376
2727377
2727378
2727380
2727381
2727382
2727383
2727386
2727387
2727388
2727389
2727391
2727393
2727395
2727396
2727397
2727398
2727401
2727402
2727403
2727404
2727406
2727407
2727408
2727411
2727413
2727414
2727415
5156
8095080
84284_at
A_14_P111616
A_14_P125923
A_23_P300033
A_23_P332536
GE57864
GO:0000166
GO:0001553
GO:0001701
GO:0001775
GO:0002244
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005018
GO:0005021
GO:0005161
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0005902
GO:0005929
GO:0006468
GO:0006629
GO:0006935
GO:0007010
GO:0007155
GO:0007169
GO:0008210
GO:0008284
GO:0008585
GO:0009653
GO:0009887
GO:0009897
GO:0009986
GO:0010544
GO:0010863
GO:0016020
GO:0016301
GO:0016310
GO:0016477
GO:0016740
GO:0018108
GO:0022414
GO:0023019
GO:0023052
GO:0030054
GO:0030154
GO:0030198
GO:0030324
GO:0030325
GO:0030335
GO:0030539
GO:0032956
GO:0032991
GO:0033327
GO:0034614
GO:0035790
GO:0036211
GO:0038085
GO:0038091
GO:0042060
GO:0042475
GO:0042803
GO:0042995
GO:0043226
GO:0043235
GO:0044877
GO:0046777
GO:0048008
GO:0048146
GO:0048407
GO:0048557
GO:0048584
GO:0048701
GO:0048704
GO:0048705
GO:0048856
GO:0048870
GO:0050850
GO:0050872
GO:0050921
GO:0051897
GO:0055003
GO:0060021
GO:0060089
GO:0060325
GO:0060326
GO:0061298
GO:0070374
GO:0070527
GO:0071230
GO:0071363
GO:0072277
GO:0140096
GO:2000739
HMNXSV003051985
HMNXSV003054613
Hs.166074.0.S1_3p_at
Hs2.74615.2.A1_3p_at
Hs2.74615.2.A1_3p_s_at
ILMN_1681949
ILMN_2086470
M21574_at
PH_hs_0004257
TC04002931.hg
g5453869_3p_at
Participates
Other forms of this molecule
Modified Residues
Name
L-aspartic acid 842 replaced with L-tyrosine
Coordinate
842
PsiMod
A protein modification that effectively removes or replaces an L-aspartic acid.
A protein modification that effectively converts a source amino acid residue to L-tyrosine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
gastrointestinal stromal tumor DOID:9253 GANT, GIST, Stromal tumor of gastrointestinal tract
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC - Biogenic
ZINC target
PRO
ZINC - Investigational
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (10)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P01127 PDGFB  8 0.733 11
 UniProt:P09619 PDGFRB  3 0.706 5
 UniProt:P04085 PDGFA  1 0.691 6
 UniProt:P00533 EGFR  20 0.683 4
 UniProt:P46108 CRK  1 0.671 4
 UniProt:Q9NRA1 PDGFC      0.656 3
 UniProt:P46109 CRKL  2 0.569 3
 UniProt:Q8N6L0 KASH5      0.556 3
 UniProt:P19174 PLCG1  6 0.544 3
 UniProt:Q8WVM8 SCFD1  1 0.483 2
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