PDGFRA D846V [plasma membrane]

Stable Identifier
R-HSA-9674306
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
Alpha platelet-derived growth factor receptor, PGDS_HUMAN
PDGFRA D846V [plasma membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
30318721 Prolonged response to sorafenib in a patient with refractory metastatic osteosarcoma and a somatic PDGFRA D846V mutation

Armstrong, AE, Reichek, J, Leavey, PJ, Walterhouse, DO, Walz, AL

Pediatr Blood Cancer 2019
External Reference Information
External Reference
Gene Names
PDGFRA, PDGFR2, RHEPDGFRA
Chain
signal peptide:1-23, chain:24-1089
Participates
Other forms of this molecule
Modified Residues
Name
L-aspartic acid 846 replaced with L-valine
Coordinate
846
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-valine.
A protein modification that effectively removes or replaces an L-aspartic acid.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
gastrointestinal stromal tumor DOID:9253 GANT, GIST, Stromal tumor of gastrointestinal tract
osteosarcoma DOID:3347 osteoid sarcoma, Skeletal sarcoma, Osteogenic sarcoma, bone tissue neoplasm
lung squamous cell carcinoma DOID:3907 squamous cell carcinoma of lung (disorder), Epidermoid cell carcinoma of the lung
Cross References
Interactors (10)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P01127 PDGFB  8 0.733 11
 UniProt:P09619 PDGFRB  3 0.706 5
 UniProt:P04085 PDGFA  1 0.691 6
 UniProt:P00533 EGFR  20 0.683 4
 UniProt:P46108 CRK  1 0.671 4
 UniProt:Q9NRA1 PDGFC      0.656 3
 UniProt:P46109 CRKL  2 0.569 3
 UniProt:Q8N6L0 KASH5      0.556 3
 UniProt:P19174 PLCG1  6 0.544 3
 UniProt:Q8WVM8 SCFD1  1 0.483 2
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