Reactome | IFI16 [cytosol]

IFI16 [cytosol]

Stable Identifier

R-HSA-1834934

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Gamma-interferon-inducible protein 16

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q16666 IFI16

Gene Names

IFI16, IFNGIP1

Chain

chain:1-785

Reference Genes

BioGPS Gene:3428 IFI16

COSMIC (genes):IFI16 IFI16

CTD Gene:3428 IFI16

dbSNP Gene:3428 IFI16

ENSEMBL:ENSG00000163565 IFI16

HGNC:5395 IFI16

KEGG Gene (Homo sapiens):3428 IFI16

Monarch:3428 IFI16

NCBI Gene:3428 IFI16

OMIM:147586 IFI16

UCSC:Q16666 IFI16

Reference Transcript

Other Identifiers

11716795_s_at

11716796_s_at

11747926_s_at

1456_s_at

16672390

206332_s_at

208965_s_at

208966_x_at

2362405

2362406

2362407

2362408

2362411

2362413

2362416

2362417

2362422

2362428

2362435

2362439

2362442

2362443

2362444

2362447

2362450

2362451

2362452

3428

7906400

A_23_P160025

A_23_P217866

GE58028

GO:0000122

GO:0000978

GO:0001227

GO:0001819

GO:0002218

GO:0002376

GO:0003674

GO:0003677

GO:0003690

GO:0003700

GO:0003723

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0006914

GO:0006915

GO:0006950

GO:0006954

GO:0007165

GO:0008134

GO:0008150

GO:0008219

GO:0009056

GO:0009058

GO:0010506

GO:0016020

GO:0016607

GO:0030099

GO:0030154

GO:0030224

GO:0032481

GO:0032731

GO:0034641

GO:0035458

GO:0040029

GO:0042149

GO:0042771

GO:0043226

GO:0043392

GO:0044403

GO:0045071

GO:0045087

GO:0045824

GO:0045892

GO:0045944

GO:0048856

GO:0051604

GO:0051607

GO:0071479

GO:0072332

GO:0097202

GO:2000117

Hs.155530.1.A1_3p_a_at

ILMN_1710937

ILMN_1803457

M63838_s_at

PH_hs_0027408

TC01001348.hg

TC01004781.hg

g5031778_3p_a_at

Participant Of

input

IFI16 binds cytosolic dsDNA

hasComponent

dsDNA:IFI16 [cytosol]

Cross References

RefSeq

NP_001193496.1, NP_005522.2

OpenTargets

ENSG00000163565

GeneCards

Q16666

HPA

ENSG00000163565-IFI16

Ensembl

ENST00000368132, ENSP00000404325, ENSG00000163565, ENST00000295809, ENSP00000357113, ENSP00000352740, ENST00000448393, ENST00000359709, ENSP00000357114, ENST00000368131, ENSP00000295809

PRO

Q16666

PDB

3RNU, 3RLN, 3RLO, 3B6Y, 2OQ0, 4QGU

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P38398 BRCA1	27	SUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) SUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) BRCA1 C64R [nucleoplasm] (R-HSA-9700907) BRCA1 C61G [nucleoplasm] (R-HSA-9700890) BRCA1 C39Y [nucleoplasm] (R-HSA-9700938) BRCA1 H41R [nucleoplasm] (R-HSA-9700921) BRCA1 C24R [nucleoplasm] (R-HSA-9663198) BRCA1 H41A [nucleoplasm] (R-HSA-9700927) BRCA1 M18T [nucleoplasm] (R-HSA-9700911) BRCA1 C47G [nucleoplasm] (R-HSA-9700941) BRCA1 C64G [nucleoplasm] (R-HSA-9700899) BRCA1 C44F [nucleoplasm] (R-HSA-9700944) BRCA1 T37R [nucleoplasm] (R-HSA-9700934) BRCA1 C27A [nucleoplasm] (R-HSA-9700916) BRCA1 H41Q [nucleoplasm] (R-HSA-9700923) BRCA1 Q12Tfs5 [nucleoplasm] (R-HSA-9700953) BRCA1 E23Afs18 [nucleoplasm] (R-HSA-9700959) BRCA1 C61Y [nucleoplasm] (R-HSA-9700894) BRCA1 C24F [nucleoplasm] (R-HSA-9663206) BRCA1 E23Rfs18 [nucleoplasm] (R-HSA-9700960) BRCA1 E23Vfs17 [nucleoplasm] (R-HSA-9700967) p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-5683800) K6PolyUb,p-S988,S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707298) BRCA1 [nucleoplasm] (R-HSA-50949) K6PolyUb-BRCA1 [nucleoplasm] (R-HSA-9701022) K6PolyUb,p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-9707290) p-S1387,S1423,S1524,S1547-BRCA1 [nucleoplasm] (R-HSA-75234)	0.556	9
UniProt:P10275 AR	4	SUMO1-K386,520-AR [nucleoplasm] (R-HSA-4090320) PolyUb-AR [nucleoplasm] (R-HSA-6782984) AR [cytosol] (R-HSA-5618082) AR [nucleoplasm] (R-HSA-446174)	0.524	3
UniProt:Q86WV6 STING1	5	TMEM173 [secretory granule membrane] (R-HSA-6804798) TMEM173 [plasma membrane] (R-HSA-6804815) K63polyUb-STING [endoplasmic reticulum membrane] (R-HSA-3134805) K63polyUb-STING [cytoplasmic vesicle membrane] (R-HSA-3248021) TMEM173 [endoplasmic reticulum membrane] (R-HSA-1834940)	0.524	2
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.488	2

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