Reactome | KAT2A [nucleoplasm]

KAT2A [nucleoplasm]

Stable Identifier

R-HSA-3006516

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Histone acetyltransferase KAT2A, KAT2A_HUMAN, GCN5

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Developmental Biology (Homo sapiens)

- Regulation of beta-cell development (Homo sapiens)
  - Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells (Homo sapiens)
    - NOTCH1 stimulates HES1 transcription (Homo sapiens)
      - NOTCH1 Coactivator Complex [nucleoplasm] (Homo sapiens)
        
        PCAF [nucleoplasm] (Homo sapiens)
        
        KAT2A [nucleoplasm] (Homo sapiens)
      - NOTCH1 Coactivator Complex:HES1 Gene [nucleoplasm] (Homo sapiens)
        
        NOTCH1 Coactivator Complex [nucleoplasm] (Homo sapiens)
        
        PCAF [nucleoplasm] (Homo sapiens)
        
        KAT2A [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP3,SAGA deubiquitinate Histone H2A,H2B (Homo sapiens)
        
        USP3, SAGA complex [nucleoplasm] (Homo sapiens)
        
        SAGA [nucleoplasm] (Homo sapiens)
        
        KAT2A [nucleoplasm] (Homo sapiens)
        
        USP3,SAGA:Histone H2A,Histone H2B [nucleoplasm] (Homo sapiens)
        
        USP3, SAGA complex [nucleoplasm] (Homo sapiens)
        
        SAGA [nucleoplasm] (Homo sapiens)
        
        KAT2A [nucleoplasm] (Homo sapiens)
        
        USP3,SAGA:Ub-histone H2A, Ub-histone H2B [nucleoplasm] (Homo sapiens)
        
        USP3, SAGA complex [nucleoplasm] (Homo sapiens)
        
        SAGA [nucleoplasm] (Homo sapiens)
        
        KAT2A [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q92830 KAT2A

Gene Names

KAT2A, GCN5, GCN5L2

Chain

initiator methionine:1, chain:2-837

Reference Genes

BioGPS Gene:2648 KAT2A

COSMIC (genes):KAT2A KAT2A

CTD Gene:2648 KAT2A

dbSNP Gene:2648 KAT2A

ENSEMBL:ENSG00000108773 KAT2A

HGNC:4201 KAT2A

KEGG Gene (Homo sapiens):2648 KAT2A

Monarch:2648 KAT2A

NCBI Gene:2648 KAT2A

OMIM:602301 KAT2A

UCSC:Q92830 KAT2A

Reference Transcript

Other Identifiers

0003610017

11744097_at

16845019

202182_at

2648

3757629

3757631

3757632

3757633

3757635

3757637

3757639

3757642

3757643

3757645

3757647

3757648

3757649

3757650

3757652

3757654

3757656

3757657

3757658

3757659

3757660

3757661

38628_at

8015526

A_23_P66608

GE54226

GO:0000123

GO:0000228

GO:0000790

GO:0001701

GO:0001756

GO:0001816

GO:0001843

GO:0002376

GO:0003674

GO:0003682

GO:0003713

GO:0004402

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005671

GO:0005694

GO:0005737

GO:0005813

GO:0005815

GO:0005856

GO:0005975

GO:0006338

GO:0006355

GO:0006357

GO:0006464

GO:0007005

GO:0007010

GO:0007049

GO:0007267

GO:0007399

GO:0007507

GO:0007616

GO:0008080

GO:0008134

GO:0008150

GO:0008283

GO:0009058

GO:0009790

GO:0010484

GO:0014070

GO:0016032

GO:0016407

GO:0016573

GO:0016578

GO:0016579

GO:0016740

GO:0016746

GO:0018393

GO:0019899

GO:0019903

GO:0021537

GO:0022037

GO:0022607

GO:0030154

GO:0030901

GO:0030914

GO:0031346

GO:0031647

GO:0031667

GO:0032991

GO:0033276

GO:0034641

GO:0035066

GO:0035264

GO:0040007

GO:0042826

GO:0043226

GO:0043966

GO:0043983

GO:0043997

GO:0044154

GO:0044281

GO:0044403

GO:0045252

GO:0045589

GO:0045722

GO:0045815

GO:0045893

GO:0045944

GO:0046600

GO:0048167

GO:0048312

GO:0048646

GO:0048856

GO:0050863

GO:0050877

GO:0051276

GO:0060173

GO:0061035

GO:0061733

GO:0071356

GO:0071929

GO:0072686

GO:0106077

GO:0106078

GO:0106227

GO:0106229

GO:1903010

GO:1990090

GO:2000036

GO:2000727

ILMN_1782247

PH_hs_0005624

TC17001524.hg

U57316_at

g10835100_3p_at

Participant Of

hasComponent

input

B-WICH recruits histone acetyltransferases

hasMember

KAT2A,B [nucleoplasm]

hasCandidate

PCAF [nucleoplasm]

Inferred To

Gcn5 [nucleoplasm] (Drosophila melanogaster)

Kat2a [nucleoplasm] (Mus musculus)

Kat2a [nucleoplasm] (Rattus norvegicus)

pcaf-1 [nucleoplasm] (Caenorhabditis elegans)

gcn5 [nucleoplasm] (Schizosaccharomyces pombe)

GCN5 [nucleoplasm] (Saccharomyces cerevisiae)

KAT2A [nucleoplasm] (Bos taurus)

KAT2A [nucleoplasm] (Canis familiaris)

KAT2A [nucleoplasm] (Gallus gallus)

KAT2A [nucleoplasm] (Sus scrofa)

kat2a [nucleoplasm] (Danio rerio)

kat2a [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_066564.2, XP_016879937.1

OpenTargets

ENSG00000108773

GeneCards

Q92830

HPA

ENSG00000108773-KAT2A

ZINC target

Q92830

Ensembl

ENSG00000108773, ENST00000225916, ENSP00000225916

PRO

Q92830

HMDB Protein

HMDBP02536

PDB

6J3P, 5MLJ, 5TRM, 1Z4R, 3D7C, 5H86, 1F68, 5H84, 5TRL

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y4A5 TRRAP	1	TRRAP [nucleoplasm] (R-HSA-3322951)	0.69	5
UniProt:O15265 ATXN7	2	ATXN7 [cytosol] (R-HSA-201591) ATXN7 [nucleoplasm] (R-HSA-8869458)	0.662	6
UniProt:P49336 CDK8	1	CDK8 [nucleoplasm] (R-HSA-212440)	0.662	5
UniProt:Q96ES7 SGF29	1	SGF29 [nucleoplasm] (R-HSA-3662279)	0.643	3
UniProt:O75717 WDHD1			0.619	5
UniProt:Q01094 E2F1	2	p-E2F1 [nucleoplasm] (R-HSA-187911) E2F1 [nucleoplasm] (R-HSA-68639)	0.564	2
UniProt:Q9NY61 AATF	1	AATF [cytosol] (R-HSA-205071)	0.543	4
UniProt:P43363 MAGAA			0.527	2
UniProt:O75528 TADA3	1	TADA3 [nucleoplasm] (R-HSA-3322966)	0.527	2
UniProt:O75478 TADA2A	1	TADA2A [nucleoplasm] (R-HSA-3662284)	0.527	3
UniProt:Q93074 MED12	1	MED12 [nucleoplasm] (R-HSA-212343)	0.527	2
UniProt:Q8IYH5 ZZZ3	1	ZZZ3 [nucleoplasm] (R-HSA-3662283)	0.499	2

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