Liganded Gq/11-activating GPCRs act as GEFs for Gq/11

Stable Identifier
R-HSA-379048
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

G alpha q protein (or Gq/11) consists of four family members (G-alpha 11, -alpha 14, -alpha 15 and -alpha q). It activates phospholipase C (PLC) (Dowal L et al, 2006). PLC hydrolyzes phosphatidylinositol (PIP2) to diacyl glycerol (DAG) and inositol triphosphate (IP3). DAG acts as a second messenger that activates protein kinase C (PKC) and IP3 can bind to IP3 receptors, particular calcium channels in the endoplasmic reticulum (ER). Calcium flow causes the cytosolic concentration of calcium to increase, causing a cascade of intracellular changes and activity.

Literature References
PubMed ID Title Journal Year
16754659 Stable association between G alpha(q) and phospholipase C beta 1 in living cells

Dowal, L, Provitera, P, Scarlata, S

J Biol Chem 2006
1905813 G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells

Amatruda TT, 3rd, Steele, DA, Slepak, VZ, Simon, MI

Proc Natl Acad Sci U S A 1991
3086311 The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins

Ferguson, KM, Higashijima, T, Smigel, MD, Gilman, AG

J Biol Chem 1986
8664309 Human G(alpha q): cDNA and tissue distribution

Chen, B, Leverette, RD, Schwinn, DA, Kwatra, MM

Biochim Biophys Acta 1996
10191087 Genomic organization of the human galpha14 and Galphaq genes and mutation analysis in chorea-acanthocytosis (CHAC)

Rubio, JP, Levy, ER, Dobson-Stone, C, Monaco, AP

Genomics 1999
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed