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FANCG [cytosol]
Stable Identifier
R-HSA-420788
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Fanconi anemia group G protein, FANCG_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Interferon Signaling (Homo sapiens)
Antiviral mechanism by IFN-stimulated genes (Homo sapiens)
PKR-mediated signaling (Homo sapiens)
FA core complex:HSP70s binds PKR (Homo sapiens)
FA Core Complex:HSP70s [cytosol] (Homo sapiens)
FA Core Complex [cytosol] (Homo sapiens)
FANCG [cytosol] (Homo sapiens)
FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
FA Core Complex:HSP70s [cytosol] (Homo sapiens)
FA Core Complex [cytosol] (Homo sapiens)
FANCG [cytosol] (Homo sapiens)
PKR forms a dimer (Homo sapiens)
FA Core Complex:HSP70s:EIF2AK2 [cytosol] (Homo sapiens)
FA Core Complex:HSP70s [cytosol] (Homo sapiens)
FA Core Complex [cytosol] (Homo sapiens)
FANCG [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15287 FANCG
Gene Names
FANCG, XRCC9
Chain
chain:1-622
Reference Genes
BioGPS Gene:2189 FANCG
COSMIC (genes):FANCG FANCG
CTD Gene:2189 FANCG
dbSNP Gene:2189 FANCG
ENSEMBL:ENSG00000221829 FANCG
ENSEMBL_homo_sapiens_GENE:ENSG00000221829.11 FANCG
HGNC:3588 FANCG
KEGG Gene (Homo sapiens):2189 FANCG
Monarch:2189 FANCG
NCBI Gene:2189 FANCG
OMIM:602956 FANCG
Reference Transcript
RefSeq:NM_004629.1 FANCG
Other Identifiers
11756256_a_at
17093595
203564_PM_at
203564_at
2189
3204120
3204464
3204465
3204467
3204468
3204469
3204472
3204475
3204476
3204477
3204478
3204479
3204480
3204482
3204483
3204485
3204486
3204487
3204488
3204489
3204490
3204492
3204493
3204494
3204495
37584_at
8160935
A_23_P71644
GE55181
GO:0000785
GO:0001541
GO:0003677
GO:0003684
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005730
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006281
GO:0006974
GO:0007005
GO:0007286
GO:0009314
GO:0022414
GO:0030154
GO:0036297
GO:0043226
GO:0043240
GO:0048856
HMNXSV003030302
ILMN_1758728
PH_hs_0025352
TC09001049.hg
g4759335_3p_at
Participates
as a component of
FA Core Complex [cytosol] (Homo sapiens)
Other forms of this molecule
FANCG [nucleoplasm]
Inferred To
FANCG [cytosol]
(Bos taurus)
FANCG [cytosol]
(Canis familiaris)
FANCG [cytosol]
(Gallus gallus)
FANCG [cytosol]
(Sus scrofa)
fancg [cytosol]
(Xenopus tropicalis)
Fancg [cytosol]
(Mus musculus)
Fancg [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_004620.1
OpenTargets
ENSG00000221829
HPA
ENSG00000221829-FANCG
GeneCards
O15287
Ensembl
ENST00000378643
,
ENST00000448890
,
ENSG00000221829
,
ENSP00000409607
,
ENSP00000367910
PRO
O15287
Pharos - Targets
O15287
Orphanet
16026
PDB
7KZT
,
7KZP
,
7KZR
,
7KZV
,
7KZQ
,
7KZS
Interactors (55)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15360 FANCA
2
FANCA [nucleoplasm]
(R-HSA-419541)
FANCA [cytosol]
(R-HSA-420796)
0.961
26
UniProt:Q9NPI8 FANCF
2
FANCF [cytosol]
(R-HSA-420794)
FANCF [nucleoplasm]
(R-HSA-419537)
0.75
6
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q99633 PRPF18
1
PRPF18 [nucleoplasm]
(R-HSA-5688093)
0.556
3
UniProt:Q8TD31-3 CCHCR1
0.556
3
UniProt:P51687 SUOX
1
SUOX [mitochondrial matrix]
(R-HSA-1614570)
0.556
3
UniProt:Q9BVL2 NUP58
0.556
3
UniProt:Q86UD4 ZN329
0.556
3
UniProt:Q13393 PLD1
4
PLD1 [endoplasmic reticulum membrane]
(R-HSA-1498795)
PLD1 [plasma membrane]
(R-HSA-2028998)
PLD1 [tertiary granule membrane]
(R-HSA-6800955)
PLD1 [specific granule membrane]
(R-HSA-6799531)
0.556
3
IntAct:EBI-25847655 CCSB
0.556
3
UniProt:Q8N7U7-2 TPRX1
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:Q8N8B7-2 TCEANC
0.556
3
UniProt:Q8WXH2 JPH3
0.556
3
UniProt:P60891 PRPS1
1
PRPS1 [cytosol]
(R-HSA-73483)
0.556
3
UniProt:P14079 TAX
0.556
3
UniProt:G5E9A7 G5E9A7
0.556
3
UniProt:O14901 KLF11
0.556
3
UniProt:Q92870-2 Q928702
0.556
3
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.556
3
UniProt:P14136 GFAP
3
p-GFAP [lysosomal membrane]
(R-HSA-9626054)
GFAP [lysosomal membrane]
(R-HSA-9625195)
GFAP [cytosol]
(R-HSA-1253311)
0.556
3
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.556
3
UniProt:P08684 CYP3A4
1
CYP3A4 [endoplasmic reticulum membrane]
(R-HSA-52639)
0.556
3
UniProt:Q53GS7 GLE1
1
GLE1 [nucleoplasm]
(R-HSA-8932905)
0.556
3
UniProt:P29474 NOS3
9
2xPalmC-MyrG-p-S1177,S1179-NOS3 [plasma membrane]
(R-HSA-9860783)
2xPalmC-MyrG-p-S633-NOS3 [plasma membrane]
(R-HSA-9861341)
2xPalmC-MyrG-NOS3 [endocytic vesicle membrane]
(R-HSA-535007)
2xPalmC-MyrG-p-S1177-NOS3 [plasma membrane]
(R-HSA-202139)
MyrG-NOS3 [Golgi membrane]
(R-HSA-534995)
MyrG-NOS3 [cytosol]
(R-HSA-203687)
2xPalmC-MyrG-NOS3 [plasma membrane]
(R-HSA-534993)
2xPalmC-MyrG-NOS3 [Golgi membrane]
(R-HSA-203769)
NOS3 [cytosol]
(R-HSA-202114)
0.556
3
UniProt:P16284 PECAM1
5
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
0.556
3
UniProt:P20339 RAB5A
7
GGC-RAB5A [clathrin-coated endocytic vesicle membrane]
(R-HSA-8871125)
GGC-RAB5A [early endosome membrane]
(R-HSA-8875323)
GGC-RAB5A [cytosol]
(R-HSA-8870432)
RAB5A [early endosome membrane]
(R-HSA-2130175)
RAB5A [cytosol]
(R-HSA-2201187)
GGC-RAB5A [macropinosome membrane]
(R-HSA-9837697)
RAB5A [endosome membrane]
(R-HSA-452257)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:P19404 NDUFV2
1
NDUFV2 [mitochondrial inner membrane]
(R-HSA-163939)
0.556
3
UniProt:Q8N6Y0 USBP1
0.553
2
UniProt:O96006 ZBED1
1
ZBED1 [nucleoplasm]
(R-HSA-8956376)
0.553
2
UniProt:P08727 KRT19
1
KRT19 [cytosol]
(R-HSA-6809617)
0.553
2
UniProt:P16444 DPEP1
1
DPEP1 [plasma membrane]
(R-HSA-2142820)
0.527
3
UniProt:P32970 CD70
1
CD70 [plasma membrane]
(R-HSA-5667139)
0.527
3
UniProt:Q9H0L4 CSTF2T
1
CSTF2T [nucleoplasm]
(R-HSA-8938786)
0.527
2
UniProt:O43252 PAPSS1
3
PAPSS1 [cytosol]
(R-HSA-174387)
PAPSS1(1-223)-BRAF(381-766) fusion [cytosol]
(R-HSA-6802432)
PAPSS1(1-223)-p-BRAF(381-766) fusion [cytosol]
(R-HSA-6802543)
0.527
2
UniProt:P06028 GYPB
1
GYPB [plasma membrane]
(R-HSA-8867209)
0.527
2
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.527
2
UniProt:Q13813 SPTAN1
6
SPTAN1 [cytosol]
(R-HSA-201601)
SPTAN1(1-1185) [cytosol]
(R-HSA-202944)
SPTAN1(1186-2472) [cytosol]
(R-HSA-202964)
SPTAN1 [tertiary granule lumen]
(R-HSA-6800874)
SPTAN1 [extracellular region]
(R-HSA-6806322)
SPTAN1 [specific granule lumen]
(R-HSA-6799533)
0.508
4
UniProt:P15976-2 GATA1
0.488
2
UniProt:Q8IYA8 IHO1
0.488
2
UniProt:O15360-3 O153603
0.488
5
UniProt:Q6NUQ1 RINT1
1
RINT1 [cytosol]
(R-HSA-6810991)
0.488
2
UniProt:P13646 KRT13
1
KRT13 [cytosol]
(R-HSA-6809591)
0.488
2
UniProt:Q08117-2 TLE5
0.488
2
UniProt:Q9Y2V7 COG6
2
COG6 [Golgi membrane]
(R-HSA-2980958)
COG6 [trans-Golgi network membrane]
(R-HSA-6813872)
0.488
2
UniProt:Q7Z6G3-2 NECAB2
0.488
2
UniProt:Q8NA61-2 CBY2
0.488
2
UniProt:Q9Y2K1 ZBTB1
0.488
2
UniProt:Q9UKT9 IKZF3
0.488
2
IntAct:EBI-11742485 SSX2IP
0.488
2
UniProt:Q8N448 LNX2
0.488
2
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.488
2
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.488
2
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