Reactome | SPTAN1 [specific granule lumen]

SPTAN1 [specific granule lumen]

Stable Identifier

R-HSA-6799533

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

specific granule lumen

Synonyms

spectrin alpha chain, brain/alpha II fodrin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13813 SPTAN1

Gene Names

SPTAN1, NEAS, SPTA2

Chain

chain:1-2472

Reference Genes

BioGPS Gene:6709 SPTAN1

COSMIC (genes):SPTAN1 SPTAN1

CTD Gene:6709 SPTAN1

dbSNP Gene:6709 SPTAN1

ENSEMBL:ENSG00000197694 SPTAN1

HGNC:11273 SPTAN1

KEGG Gene (Homo sapiens):6709 SPTAN1

Monarch:6709 SPTAN1

NCBI Gene:6709 SPTAN1

OMIM:182810 SPTAN1

UCSC:Q13813 SPTAN1

Reference Transcript

Other Identifiers

0003710373

11715963_a_at

11715964_x_at

11751947_a_at

11758363_s_at

17089735

208611_s_at

215235_at

3190559

3190563

3190564

3190566

3190567

3190568

3190569

3190570

3190571

3190572

3190573

3190574

3190576

3190578

3190579

3190580

3190581

3190582

3190583

3190584

3190585

3190586

3190588

3190589

3190592

3190593

3190595

3190596

3190597

3190600

3190601

3190602

3190603

3190604

3190605

3190606

3190608

3190609

3190610

3190613

3190615

3190616

3190618

3190619

3190620

3190621

3190622

3190624

3190627

3190628

3190630

3190631

3190636

3190638

3190639

3190640

3190642

3190644

3190645

3190646

33833_at

6709

8158317

89935_at

A_14_P112681

A_14_P136143

A_23_P20832

A_33_P3373560

GE81239

GO:0000165

GO:0000902

GO:0002376

GO:0003674

GO:0003779

GO:0005198

GO:0005200

GO:0005509

GO:0005515

GO:0005516

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005737

GO:0005829

GO:0005856

GO:0005938

GO:0006464

GO:0006810

GO:0006888

GO:0007010

GO:0007165

GO:0007411

GO:0008091

GO:0008092

GO:0008150

GO:0015630

GO:0016020

GO:0016192

GO:0022607

GO:0030154

GO:0031410

GO:0032991

GO:0035580

GO:0040011

GO:0043167

GO:0043226

GO:0043231

GO:0043312

GO:0045296

GO:0046872

GO:0048856

GO:0051693

GO:0065003

GO:0070062

GO:1903561

GO:1904724

Hs.77196.2.A1_3p_a_at

ILMN_1663526

J05243_at

PH_hs_0024438

TC09000695.hg

Participant Of

hasMember

Specific granule lumen proteins [specific granule lumen]

Other forms of this molecule

SPTAN1 [cytosol]

SPTAN1(1-1185) [cytosol]

SPTAN1(1186-2472) [cytosol]

SPTAN1 [tertiary granule lumen]

SPTAN1 [extracellular region]

Inferred To

abpA [specific granule lumen] (Dictyostelium discoideum)

Sptan1 [specific granule lumen] (Mus musculus)

Sptan1 [specific granule lumen] (Rattus norvegicus)

ain1 [specific granule lumen] (Schizosaccharomyces pombe)

sptan1 [specific granule lumen] (Danio rerio)

sptan1 [specific granule lumen] (Xenopus tropicalis)

spc-1 [specific granule lumen] (Caenorhabditis elegans)

SPTAN1 [specific granule lumen] (Bos taurus)

SPTAN1 [specific granule lumen] (Canis familiaris)

SPTAN1 [specific granule lumen] (Sus scrofa)

alpha-Spec [specific granule lumen] (Drosophila melanogaster)

Cross References

RefSeq

NP_001182461.1, NP_001123910.1, NP_003118.2

OpenTargets

ENSG00000197694

GeneCards

Q13813

HPA

ENSG00000197694-SPTAN1

Ensembl

ENSP00000350882, ENST00000372731, ENSP00000361824, ENST00000372739, ENST00000358161, ENSP00000361816, ENSG00000197694

PRO

Q13813

Orphanet

19240

HMDB Protein

HMDBP08004

PDB

5FWB, 5FW9, 3FB2, 3F31, 5FWC, 2FOT

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q01082 SPTBN1	1	SPTBN1 [cytosol] (R-HSA-420048)	0.609	8
UniProt:P40692 MLH1	3	MLH1 H329P [nucleoplasm] (R-HSA-5444512) MLH1 S252* [nucleoplasm] (R-HSA-5444526) MLH1 [nucleoplasm] (R-HSA-912495)	0.602	7
UniProt:Q9UI08 EVL	1	EVL [cytosol] (R-HSA-426403)	0.593	4
UniProt:Q00597 FANCC	1	FANCC [nucleoplasm] (R-HSA-419530)	0.589	2
UniProt:Q9NRI5 DISC1			0.553	3
UniProt:Q9NV70 EXOC1	2	EXOC1 [cytosol] (R-HSA-5623375) EXOC1 [plasma membrane] (R-HSA-2872284)	0.553	2
UniProt:P42224 STAT1	7	p-STAT1 [cytosol] (R-HSA-8950418) p-STAT1 [nucleoplasm] (R-HSA-8987140) p-Y701-STAT1 [nucleoplasm] (R-HSA-6788624) p-Y701-STAT1 [cytosol] (R-HSA-3132766) STAT1 [cytosol] (R-HSA-629622) p-Y701-STAT1 [cytosol] (R-HSA-8951202) p-Y701-STAT1 [nucleoplasm] (R-HSA-8985905)	0.547	2
UniProt:O15287 FANCG	1	FANCG [nucleoplasm] (R-HSA-419532)	0.508	4
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2
1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]	6	PI(3,4,5)P3 [endocytic vesicle membrane] (R-ALL-917725) PIP3 [plasma membrane] (R-ALL-38117) PI(3,4,5)P3 [endosome membrane] (R-ALL-917716) PI(3,4,5)P3 [early endosome membrane] (R-ALL-8849955) PI(3,4,5)P3 [cytoplasmic vesicle membrane] (R-ALL-8874468) PI(3,4,5)P3 [plasma membrane] (R-ALL-179838)	0.462	2

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