Reactome | FURIN [trans-Golgi network membrane]

FURIN [trans-Golgi network membrane]

Stable Identifier

R-HSA-9832627

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

trans-Golgi network membrane

Synonyms

Furin

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Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
        
        Maturation of hRSV A proteins (Homo sapiens)
        
        F0 is cleaved, releasing F1, F2, F(110-136) (Homo sapiens)
        
        Furin-type peptidase [trans-Golgi network membrane] (Homo sapiens)
        
        FURIN [trans-Golgi network membrane] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
1629222	Activation of human furin precursor processing endoprotease occurs by an intramolecular autoproteolytic cleavage Leduc, R, Molloy, S S, Thorne, BA, Thomas, G	J Biol Chem	1992

External Reference Information

External Reference

UniProt:P09958 FURIN

Gene Names

FURIN, FUR, PACE, PCSK3

Chain

signal peptide:1-26, propeptide:27-107, chain:108-794

Reference Genes

BioGPS Gene:5045 FURIN

COSMIC (genes):FURIN FURIN

CTD Gene:5045 FURIN

dbSNP Gene:5045 FURIN

ENSEMBL:ENSG00000140564 FURIN

HGNC:8568 FURIN

KEGG:hsa:5045 FURIN

Monarch:5045 FURIN

NCBI Gene:5045 FURIN

OMIM:136950 FURIN

UCSC:P09958 FURIN

Reference Transcript

Other Identifiers

11716282_s_at

16804942

201945_PM_at

201945_at

35338_at

3608399

3608401

3608402

3608404

3608405

3608406

3608407

3608408

3608409

3608411

3608412

3608413

3608414

3608415

3608416

3608417

3608418

3608419

3608420

3608421

3608422

3608423

3608424

3608425

3608426

3608428

3608429

3608430

3608431

3608432

3608433

3608434

5045

7986092

A_23_P3368

GO:0000139

GO:0001825

GO:0002020

GO:0002862

GO:0003824

GO:0004175

GO:0004252

GO:0004867

GO:0005515

GO:0005576

GO:0005768

GO:0005783

GO:0005794

GO:0005796

GO:0005802

GO:0005886

GO:0006465

GO:0006508

GO:0007179

GO:0008201

GO:0008233

GO:0008236

GO:0009966

GO:0009986

GO:0010008

GO:0016020

GO:0016485

GO:0016486

GO:0016787

GO:0019058

GO:0019081

GO:0019082

GO:0022617

GO:0030140

GO:0030198

GO:0030574

GO:0031410

GO:0031638

GO:0032374

GO:0032804

GO:0032902

GO:0032911

GO:0032940

GO:0034369

GO:0042176

GO:0042277

GO:0043043

GO:0043226

GO:0045121

GO:0046598

GO:0046872

GO:0048406

GO:0051044

GO:0051604

GO:0052548

GO:0070062

GO:0090472

GO:0098772

GO:0140096

GO:0140447

GO:1904399

GO:1990000

HMNXSV003039920

ILMN_1790228

PH_hs_0003807

TC15000870.hg

TC15002368.hg

X17094_at

g4505578_3p_at

Participates

as a candidate of

Furin-type peptidase [trans-Golgi network membrane] (Homo sapiens)

Other forms of this molecule

FURIN [Golgi membrane]

FURIN [extracellular region]

FURIN [plasma membrane]

FURIN [Golgi lumen]

FURIN [macropinosome membrane]

Cross References

RefSeq

NP_001276753.1, NP_001276752.1, NP_002560.1

Guide to Pharmacology - Targets

2366

OpenTargets

ENSG00000140564

ENSEMBL

ENSP00000506143, ENST00000618099, ENSP00000484952, ENST00000268171, ENSP00000268171, ENST00000680053, ENSP00000483552, ENST00000610579

ZINC - Substances

FURIN_HUMAN

ZINC target

P09958

PRO

P09958

GlyGen

P09958

PDB

7QY1, 7QXY, 7QY0, 7QY2, 8OYH, 8B4V, 8B4X, 7LCU, 7O1U, 7O1W, 7QXZ, 8B4W, 7O20, 5MIM, 6YD7, 5JMO, 6YD3, 6YD4, 6EQX, 6HLE, 6HLD, 6YD2, 6EQV, 4Z2A, 6HLB, 5JXJ, 6EQW, 5JXI, 6HZD, 6A8Y, 7O1Y, 4OMD, 5JXG, 6HZB, 5JXH, 6HZC, 4RYD, 7O22, 4OMC, 6HZA

IntEnz

3.4.21.75

HPA

ENSG00000140564-FURIN

Pharos - Targets

P09958

ZINC - Predictions - Purchasable

FURIN_HUMAN

HMDB Protein

HMDBP07695

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [virion membrane] (R-COV-9698327) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.854	5
UniProt:K9N5Q8 SPIKE			0.623	3
UniProt:O14793 MSTN	1	MSTN [extracellular region] (R-HSA-9625529)	0.623	2
UniProt:P50281 MMP14	4	MMP14 [plasma membrane] (R-HSA-1442472) MMP14(21-582) [Golgi lumen] (R-HSA-1604689) MMP14 [Golgi lumen] (R-HSA-1604724) MMP14 [Golgi membrane] (R-HSA-9858808)	0.564	3
UniProt:Q9H239 MMP28			0.556	3
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:P05154 SERPINA5	1	SERPINA5 [extracellular region] (R-HSA-5591085)	0.527	2
UniProt:P55899 FCGRN			0.527	2

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