Reactome | Elongating transcript encounters a lesion in the template

Elongating transcript encounters a lesion in the template

Stable Identifier

R-HSA-113429

Type

Reaction [dissociation]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Elongating transcript encounters a lesion in the template

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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

At the beginning of this reaction, 1 molecule of 'Processive elongation complex' is present. At the end of this reaction, 1 molecule of 'DSIF complex', 1 molecule of 'FACT complex', 1 molecule of 'RNA Polymerase II holoenzyme complex (hyperphosphorylated)', 1 molecule of 'damaged DNA substrate:nascent mRNA hybrid', 1 molecule of 'Elongin Complex', 1 molecule of 'FCP1P protein', 1 molecule of 'P-TEFb complex', 1 molecule of 'NELF complex', 1 molecule of 'RNA polymerase II elongation factor ELL', 1 molecule of 'NTP', 1 molecule of 'TFIIS protein', and 1 molecule of 'TFIIF' are present.

This reaction takes place in the 'nucleus' (Woudstra et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
11859374	A Rad26-Def1 complex coordinates repair and RNA pol II proteolysis in response to DNA damage Woudstra, EC, Gilbert, C, Fellows, J, Jansen, L, Brouwer, J, Erdjument-Bromage, H, Tempst, P, Svejstrup, JQ	Nature	2002
15489290	Elongation by RNA polymerase II: the short and long of it Sims, RJ, Belotserkovskaya, R, Reinberg, D	Genes Dev.	2004