Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
CASP9(?-315) [cytosol]
Stable Identifier
R-HSA-141638
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
CASP9 p35, Caspase-9 subunit p35, Caspase-9 (large subunit)
Icon
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Caspase activation via extrinsic apoptotic signalling pathway (Homo sapiens)
Caspase activation via Dependence Receptors in the absence of ligand (Homo sapiens)
Activation of caspase-3 (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
DCC:DIP13alpha:Caspase-9 [plasma membrane] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
Caspase-9 binds DCC:DIP13alpha complex (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
DCC:DIP13alpha:Caspase-9 [plasma membrane] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
Intrinsic Pathway for Apoptosis (Homo sapiens)
Apoptotic factor-mediated response (Homo sapiens)
Cytochrome c-mediated apoptotic response (Homo sapiens)
Activation of caspases through apoptosome-mediated cleavage (Homo sapiens)
Cleavage of Procaspase-3 by the apoptosome (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
Cleavage of Procaspase-7 by the apoptosome (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
Formation of apoptosome (Homo sapiens)
Cleavage of Procaspase‑9 to caspase‑9 (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
Regulation of the apoptosome activity (Homo sapiens)
UACA binds apoptosome (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
UACA:apoptosome [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
XIAP binds CASP9 (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
XIAP:apoptosome [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
SMAC, XIAP-regulated apoptotic response (Homo sapiens)
SMAC (DIABLO) binds to IAPs (Homo sapiens)
SMAC binds XIAP within apoptosome (Homo sapiens)
APAF1:CYCS:CASP9:XIAP:DIABLO [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
XIAP:apoptosome [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes (Homo sapiens)
Dissociation of DIABLO:XIAP from the apoptosome complex (Homo sapiens)
APAF1:CYCS:CASP9:XIAP:DIABLO [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
Apoptosome [cytosol] (Homo sapiens)
Cleaved Caspase-9 [cytosol] (Homo sapiens)
CASP9(?-315) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P55211 CASP9
Gene Names
CASP9, MCH6
Chain
propeptide:1-, chain:-315, propeptide:316-330, chain:331-416
Reference Genes
BioGPS Gene:842 CASP9
COSMIC (genes):CASP9 CASP9
CTD Gene:842 CASP9
dbSNP Gene:842 CASP9
ENSEMBL:ENSG00000132906 CASP9
HGNC:1511 CASP9
KEGG:hsa:842 CASP9
Monarch:842 CASP9
NCBI Gene:842 CASP9
OMIM:602234 CASP9
UCSC:P55211 CASP9
Reference Transcript
RefSeq:NM_032996.3 CASP9
RefSeq:NM_001278054.1 CASP9
RefSeq:NM_001229.4 CASP9
RefSeq:XM_005246014.2 CASP9
Other Identifiers
11741401_a_at
11748782_a_at
16681996
203984_PM_s_at
203984_s_at
210775_PM_x_at
210775_x_at
237451_PM_x_at
237451_x_at
2397696
2397697
2397698
2397699
2397700
2397701
2397702
2397703
2397704
2397705
2397706
2397707
2397708
2397710
2397711
2397713
2397714
2397715
2397716
2397717
2397718
2397719
2397720
2397721
2397722
2397723
2397725
2397726
240437_PM_at
240437_at
486_at
487_g_at
7912646
842
A_23_P97309
A_24_P111342
GE59272
GO:0001666
GO:0001822
GO:0002931
GO:0003824
GO:0004197
GO:0005515
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0006508
GO:0006915
GO:0006974
GO:0008047
GO:0008233
GO:0008234
GO:0008303
GO:0008630
GO:0008635
GO:0009411
GO:0012501
GO:0014070
GO:0016485
GO:0016787
GO:0017124
GO:0019901
GO:0030154
GO:0030220
GO:0032025
GO:0032355
GO:0032496
GO:0032991
GO:0034349
GO:0034644
GO:0042770
GO:0042802
GO:0042981
GO:0043065
GO:0043226
GO:0043293
GO:0043525
GO:0044346
GO:0048856
GO:0051402
GO:0051604
GO:0071407
GO:0071549
GO:0071887
GO:0097153
GO:0097193
GO:0097199
GO:0098772
GO:0140096
GO:1904019
HMNXSV003028640
Hs.34174.1.A1_3p_at
ILMN_1718070
ILMN_1786046
PH_hs_0023824
TC01002245.hg
U60521_at
g1532150_3p_s_at
g5103139_3p_s_at
Participates
as a component of
Cleaved Caspase-9 [cytosol] (Homo sapiens)
Other forms of this molecule
CASP9(1-416) [cytosol]
CASP9(331-416) [cytosol]
p-T412-CASP9(1-416) [cytosol]
p-S196-CASP9(1-416) [cytosol]
Inferred To
CASP9(?-315) [cytosol]
(Gallus gallus)
Dcp-1 [cytosol]
(Drosophila melanogaster)
CASP9 [cytosol]
(Bos taurus)
CASP9 [cytosol]
(Canis familiaris)
CASP9 [cytosol]
(Sus scrofa)
Damm [cytosol]
(Drosophila melanogaster)
Strica [cytosol]
(Drosophila melanogaster)
casp20 [cytosol]
(Danio rerio)
Dredd [cytosol]
(Drosophila melanogaster)
Casp9 [cytosol]
(Mus musculus)
Casp9 [cytosol]
(Rattus norvegicus)
Drice [cytosol]
(Drosophila melanogaster)
Homologues of CASP9(?-315) [cytosol]
(Drosophila melanogaster)
casp9 [cytosol]
(Xenopus tropicalis)
Decay [cytosol]
(Drosophila melanogaster)
ced-3 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001264983.1
,
NP_127463.2
,
NP_001220.2
,
XP_005246071.1
Guide to Pharmacology - Targets
1625
OpenTargets
ENSG00000132906
ENSEMBL
ENST00000348549
,
ENSP00000365051
,
ENST00000375890
,
ENSP00000330237
,
ENST00000333868
,
ENSP00000255256
ZINC - Substances
CASP9_HUMAN
ZINC target
P55211
PRO
P55211
GlyGen
P55211
PDB
5WVC
,
4RHW
,
5JUY
,
2AR9
,
5WVE
,
1JXQ
,
1NW9
,
3V3K
,
3YGS
,
3D9T
IntEnz
3.4.22.62
HPA
ENSG00000132906-CASP9
Pharos - Targets
P55211
ZINC - Predictions - Purchasable
CASP9_HUMAN
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P98170 XIAP
3
XIAP [cytosol]
(R-HSA-50849)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [nucleoplasm]
(R-HSA-3322366)
0.97
25
UniProt:O14727 APAF1
4
APAF1 [ficolin-1-rich granule lumen]
(R-HSA-6801301)
APAF1 [extracellular region]
(R-HSA-6806465)
APAF1 [secretory granule lumen]
(R-HSA-6801271)
APAF1 [cytosol]
(R-HSA-50099)
0.964
25
UniProt:Q96CA5 BIRC7
1
BIRC7 [cytosol]
(R-HSA-50855)
0.924
12
UniProt:Q13490 BIRC2
5
BIRC2 [cytosol]
(R-HSA-50847)
K48pUb-BIRC2 [cytosol]
(R-HSA-5675479)
BIRC2(373-618) [cytosol]
(R-HSA-202931)
BIRC2(1-372) [cytosol]
(R-HSA-202913)
K63polyUb-BIRC2 [cytosol]
(R-HSA-5668512)
0.919
12
UniProt:Q8XAL7 NLEF
0.724
6
UniProt:P42574 CASP3
5
CASP3(1-277) [cytosol]
(R-HSA-57021)
CASP3(29-175) [nucleoplasm]
(R-HSA-211194)
CASP3(176-277) [nucleoplasm]
(R-HSA-211203)
CASP3(29-175) [cytosol]
(R-HSA-141644)
CASP3(176-277) [cytosol]
(R-HSA-141646)
0.644
3
UniProt:P43146 DCC
4
p-Y1420-DCC [plasma membrane]
(R-HSA-374552)
DCC(1291-1447) [cytosol]
(R-HSA-373629)
DCC [plasma membrane]
(R-HSA-197560)
DCC(26-1290) [plasma membrane]
(R-HSA-373627)
0.589
2
IntAct:EBI-23188321 CCSB ORF ID
0.556
3
UniProt:Q6PIA0 Q6PIA0
0.556
3
IntAct:EBI-10214943 112401
0.556
3
UniProt:P83105 HTRA4
0.547
5
UniProt:O15392 BIRC5
3
BIRC5 [cytosol]
(R-HSA-50851)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
ub-BIRC5 [cytosol]
(R-HSA-8955933)
0.536
2
UniProt:Q13489 BIRC3
3
BIRC3 [cytosol]
(R-HSA-50845)
K48pUb-BIRC3 [cytosol]
(R-HSA-5675478)
K63polyUb-BIRC3 [cytosol]
(R-HSA-5668478)
0.519
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text