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CASP3(29-175) [nucleoplasm]
Stable Identifier
R-HSA-211194
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
CASP3, Caspase-3 (large subunit)
Icon
Locations in the PathwayBrowser
Expand all
Programmed Cell Death (Homo sapiens)
Apoptosis (Homo sapiens)
Apoptotic execution phase (Homo sapiens)
Apoptosis induced DNA fragmentation (Homo sapiens)
Caspase 3-mediated cleavage of DFF45 (117) (Homo sapiens)
active caspase-3 [nucleoplasm] (Homo sapiens)
CASP3(29-175):CASP3(176-277) [nucleoplasm] (Homo sapiens)
CASP3(29-175) [nucleoplasm] (Homo sapiens)
Cleavage of DFF45 (224) by caspase-3 (Homo sapiens)
active caspase-3 [nucleoplasm] (Homo sapiens)
CASP3(29-175):CASP3(176-277) [nucleoplasm] (Homo sapiens)
CASP3(29-175) [nucleoplasm] (Homo sapiens)
Translocation of caspase-3 to the nucleus (Homo sapiens)
active caspase-3 [nucleoplasm] (Homo sapiens)
CASP3(29-175):CASP3(176-277) [nucleoplasm] (Homo sapiens)
CASP3(29-175) [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
11931755
Mechanisms of caspase activation and inhibition during apoptosis
Shi, Y
Mol Cell
2002
External Reference Information
External Reference
UniProt:P42574 CASP3
Gene Names
CASP3, CPP32
Chain
propeptide:1-9, propeptide:10-28, chain:29-175, chain:176-277
Reference Genes
BioGPS Gene:836 CASP3
COSMIC (genes):CASP3 CASP3
CTD Gene:836 CASP3
dbSNP Gene:836 CASP3
ENSEMBL:ENSG00000164305 CASP3
ENSEMBL_homo_sapiens_GENE:ENSG00000164305.20 CASP3
HGNC:1504 CASP3
KEGG Gene (Homo sapiens):836 CASP3
Monarch:836 CASP3
NCBI Gene:836 CASP3
OMIM:600636 CASP3
UCSC:P42574 CASP3
Reference Transcript
RefSeq:NM_032991.2 CASP3
RefSeq:NM_004346.3 CASP3
RefSeq:XM_011532301.1 CASP3
Other Identifiers
11717805_a_at
11719838_a_at
11719839_a_at
16982011
202763_PM_at
202763_at
2796488
2796489
2796490
2796491
2796492
2796494
2796495
2796496
2796497
2796500
2796502
2796504
2796505
2796506
2796507
36143_at
8103922
836
A_23_P92410
A_33_P3278118
GE58946
GO:0001554
GO:0001666
GO:0001782
GO:0001818
GO:0002020
GO:0002376
GO:0003824
GO:0004175
GO:0004190
GO:0004197
GO:0004861
GO:0005123
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006508
GO:0006914
GO:0006915
GO:0006974
GO:0007155
GO:0007413
GO:0007507
GO:0007605
GO:0007611
GO:0008233
GO:0008234
GO:0008627
GO:0009410
GO:0009411
GO:0009611
GO:0009749
GO:0010033
GO:0010038
GO:0010165
GO:0012501
GO:0014070
GO:0016005
GO:0016241
GO:0016485
GO:0016787
GO:0021766
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030182
GO:0030216
GO:0030218
GO:0030220
GO:0030889
GO:0031264
GO:0031647
GO:0032025
GO:0032355
GO:0032496
GO:0034349
GO:0034612
GO:0035094
GO:0035556
GO:0036211
GO:0042542
GO:0043025
GO:0043029
GO:0043065
GO:0043200
GO:0043226
GO:0043525
GO:0044346
GO:0044877
GO:0045165
GO:0045786
GO:0046007
GO:0048011
GO:0048856
GO:0050877
GO:0051146
GO:0051384
GO:0051402
GO:0051604
GO:0051716
GO:0061713
GO:0070269
GO:0071310
GO:0071407
GO:0071887
GO:0072734
GO:0097153
GO:0097190
GO:0097193
GO:0097194
GO:0097199
GO:0097200
GO:0098772
GO:0140096
GO:0140639
GO:1902004
GO:1904019
HMNXSV003052694
ILMN_1731639
ILMN_2388155
PH_hs_0022563
TC04001807.hg
U13737_at
g4757911_3p_at
Participates
as a component of
CASP3(29-175):CASP3(176-277) [nucleoplasm] (Homo sapiens)
Other forms of this molecule
CASP3(1-277) [cytosol]
CASP3(176-277) [nucleoplasm]
CASP3(29-175) [cytosol]
CASP3(176-277) [cytosol]
Inferred To
Casp3 [nucleoplasm]
(Mus musculus)
Casp3 [nucleoplasm]
(Rattus norvegicus)
Drice [nucleoplasm]
(Drosophila melanogaster)
CASP3(29-175) [nucleoplasm]
(Sus scrofa)
ced-3 [nucleoplasm]
(Caenorhabditis elegans)
casp3a [nucleoplasm]
(Danio rerio)
casp3.2 [nucleoplasm]
(Xenopus tropicalis)
CASP3 [nucleoplasm]
(Bos taurus)
CASP3 [nucleoplasm]
(Canis familiaris)
CASP3 [nucleoplasm]
(Gallus gallus)
Cross References
RefSeq
NP_116786.1
,
NP_004337.2
,
XP_011530603.1
ZINC - World Drugs
CASP3_HUMAN
Guide to Pharmacology - Targets
1619
OpenTargets
ENSG00000164305
ZINC - FDA approved
CASP3_HUMAN
ZINC - Substances
CASP3_HUMAN
ZINC - Biogenic
CASP3_HUMAN
ZINC target
P42574
PRO
P42574
PDB
3ITN
,
2CNN
,
5I9B
,
4QU9
,
4QUH
,
2Y0B
,
1CP3
,
5IAR
,
2XZT
,
4JR0
,
4JQY
,
3EDQ
,
7XN5
,
4PRY
,
5IAK
,
4QUB
,
3PCX
,
1RE1
,
5IBC
,
4QUJ
,
1NMS
,
5IAB
,
2XYP
,
3GJS
,
4QU5
,
4EHN
,
4QTY
,
4EHK
,
5IC4
,
4DCP
,
3DEH
,
2C1E
,
3DEJ
,
2C2O
,
3GJQ
,
2CNL
,
2CJX
,
2C2K
,
2J32
,
4PS0
,
2XYG
,
4EHF
,
5IAG
,
2J30
,
3PD1
,
3KJF
,
2H5J
,
4EHA
,
1NME
,
5IAS
,
4QUI
,
2CNO
,
4QU8
,
1RHR
,
2DKO
,
4QUG
,
2CDR
,
4JQZ
,
1RHU
,
5IAN
,
5IBP
,
7XN6
,
4QUD
,
4DCJ
,
1GFW
,
5IAJ
,
5I9T
,
7XN4
,
1NMQ
,
4QUA
,
2H5I
,
4QUL
,
3PD0
,
1I3O
,
3GJT
,
3DEK
,
4JJE
,
4EHL
,
1PAU
,
4QU0
,
2CNK
,
3DEI
,
4DCO
,
3GJR
,
2C2M
,
4QUE
,
2CJY
,
5IBR
,
4QTX
,
4EHH
,
1RHM
,
1QX3
,
2J33
,
1RHQ
,
2XYH
,
2H65
,
2J31
,
2XZD
,
1RHJ
,
3H0E
,
4EHD
,
5IAE
,
1RHK
ZINC - Investigational
CASP3_HUMAN
IntEnz
3.4.22.56
GeneCards
P42574
HPA
ENSG00000164305-CASP3
Ensembl
ENSP00000311032
,
ENST00000700100
,
ENST00000700101
,
ENST00000523916
,
ENSP00000428929
,
ENSG00000164305
,
ENSP00000514797
,
ENST00000308394
,
ENSP00000514798
Pharos - Targets
P42574
ZINC - Predictions - Purchasable
CASP3_HUMAN
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.872
7
UniProt:P10599 TXN
4
2xHC-TXN [nucleoplasm]
(R-HSA-9617733)
TXN [nucleoplasm]
(R-HSA-9617732)
2xHC-TXN [cytosol]
(R-HSA-73668)
TXN [cytosol]
(R-HSA-66000)
0.672
6
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.659
4
UniProt:O14727 APAF1
4
APAF1 [secretory granule lumen]
(R-HSA-6801271)
APAF1 [extracellular region]
(R-HSA-6806465)
APAF1 [ficolin-1-rich granule lumen]
(R-HSA-6801301)
APAF1 [cytosol]
(R-HSA-50099)
0.653
7
UniProt:P55211 CASP9
5
p-S196-CASP9(1-416) [cytosol]
(R-HSA-198636)
p-T412-CASP9(1-416) [cytosol]
(R-HSA-9627087)
CASP9(331-416) [cytosol]
(R-HSA-141639)
CASP9(?-315) [cytosol]
(R-HSA-141638)
CASP9(1-416) [cytosol]
(R-HSA-57033)
0.644
3
UniProt:P09874 PARP1
4
polySUMO2,3-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551617)
monoSUMO1-K203,K486-PARP1 [nucleoplasm]
(R-HSA-4551686)
PAR-PARP1 [nucleoplasm]
(R-HSA-5651713)
PARP1 [nucleoplasm]
(R-HSA-201568)
0.623
2
UniProt:O60551 NMT2
1
NMT2 [cytosol]
(R-HSA-184377)
0.609
2
UniProt:Q9Y243 AKT3
6
p-T305-AKT3 [cytosol]
(R-HSA-3009370)
AKT3 [cytosol]
(R-HSA-2976007)
AKT3 [plasma membrane]
(R-HSA-2976006)
p-S472-AKT3 [plasma membrane]
(R-HSA-3009363)
p-T305,S472-AKT3 [cytosol]
(R-HSA-3009367)
p-T305,S472-AKT3 [nucleoplasm]
(R-HSA-3009365)
0.571
2
UniProt:Q00987 MDM2
11
PolyUb-MDM2 [nucleoplasm]
(R-HSA-6782472)
monoSUMO1-K182-MDM2 [nucleoplasm]
(R-HSA-3000408)
MDM2 [plasma membrane]
(R-HSA-416843)
MDM2 [endocytic vesicle membrane]
(R-HSA-416849)
p-5S,T-MDM2 [nucleoplasm]
(R-HSA-6804954)
PolyUb,p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6795669)
p-S166,S188,T218-MDM2 [nucleoplasm]
(R-HSA-6792862)
MDM2 [nucleoplasm]
(R-HSA-69486)
MDM2 [cytosol]
(R-HSA-198644)
p-S166,S188-MDM2 [cytosol]
(R-HSA-198638)
p-S166,S188-MDM2 [nucleoplasm]
(R-HSA-6793669)
0.571
2
UniProt:P55212 CASP6
5
CASP6 (1-293) [cytosol]
(R-HSA-6798132)
CASP6(194-293) [nucleoplasm]
(R-HSA-352246)
CASP6(24-179) [nucleoplasm]
(R-HSA-352247)
CASP6(24-179) [cytosol]
(R-HSA-350313)
CASP6(194-293) [cytosol]
(R-HSA-266128)
0.571
2
UniProt:P54252 ATXN3
2
ATXN3 [nucleoplasm]
(R-HSA-6783285)
ATXN3 [cytosol]
(R-HSA-5625607)
0.556
9
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
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