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p-S53-WEE1 [nucleoplasm]
Stable Identifier
R-HSA-156694
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
phospho-Wee1
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Polo-like kinase mediated events (Homo sapiens)
Inactivation of Wee1 kinase (Homo sapiens)
p-S53-WEE1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30291 WEE1
Gene Names
WEE1
Chain
chain:1-646
Reference Genes
BioGPS Gene:7465 WEE1
COSMIC (genes):WEE1 WEE1
CTD Gene:7465 WEE1
dbSNP Gene:7465 WEE1
ENSEMBL:ENSG00000166483 WEE1
ENSEMBL_homo_sapiens_GENE:ENSG00000166483.12 WEE1
HGNC:12761 WEE1
KEGG Gene (Homo sapiens):7465 WEE1
Monarch:7465 WEE1
NCBI Gene:7465 WEE1
OMIM:193525 WEE1
UCSC:P30291 WEE1
Reference Transcript
RefSeq:NM_003390.3 WEE1
RefSeq:NM_001143976.1 WEE1
Other Identifiers
11719047_s_at
16721835
2033_s_at
212533_PM_at
212533_at
215711_PM_s_at
215711_s_at
3319943
3319944
3319945
3319946
3319947
3319948
3319949
3319950
3319951
3319952
3319953
3319955
3319956
3319964
3319965
3319970
3319971
3319974
3319975
3319976
3319977
3319978
3319979
3319984
36909_at
7465
7938348
A_14_P130658
A_23_P127926
A_33_P3290567
GE59876
GE81274
GO:0000086
GO:0000166
GO:0000226
GO:0000278
GO:0000287
GO:0003824
GO:0004672
GO:0004713
GO:0004715
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0006260
GO:0006468
GO:0007010
GO:0007049
GO:0007163
GO:0010972
GO:0016301
GO:0016310
GO:0016740
GO:0030010
GO:0030154
GO:0036211
GO:0043226
GO:0045740
GO:0046872
GO:0048812
GO:0048856
GO:0051301
GO:0140096
GO:2000134
HMNXSV003022389
HMNXSV003047318
Hs.75188.1.A2_3p_at
Hs.75188.2.S1_3p_a_at
ILMN_1778561
PH_hs_0023219
TC11000174.hg
X62048_at
Participates
as an output of
Inactivation of Wee1 kinase (Homo sapiens)
Other forms of this molecule
p-WEE1 [nucleoplasm]
WEE1 [nucleoplasm]
Inferred To
phospho-p-S53-WEE1 [nucleoplasm]
(Bos taurus)
phospho-p-S53-WEE1 [nucleoplasm]
(Canis familiaris)
phospho-p-S53-WEE1 [nucleoplasm]
(Danio rerio)
phospho-p-S53-WEE1 [nucleoplasm]
(Dictyostelium discoideum)
phospho-p-S53-WEE1 [nucleoplasm]
(Drosophila melanogaster)
phospho-p-S53-WEE1 [nucleoplasm]
(Gallus gallus)
phospho-p-S53-WEE1 [nucleoplasm]
(Mus musculus)
phospho-p-S53-WEE1 [nucleoplasm]
(Rattus norvegicus)
phospho-p-S53-WEE1 [nucleoplasm]
(Saccharomyces cerevisiae)
phospho-p-S53-WEE1 [nucleoplasm]
(Schizosaccharomyces pombe)
phospho-p-S53-WEE1 [nucleoplasm]
(Sus scrofa)
phospho-p-S53-WEE1 [nucleoplasm]
(Xenopus tropicalis)
Homologues of p-S53-WEE1 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of p-S53-WEE1 [nucleoplasm]
(Schizosaccharomyces pombe)
Modified Residues
Name
O-phospho-L-serine at 53
Coordinate
53
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_001137448.1
,
NP_003381.1
ZINC - World Drugs
WEE1_HUMAN
Guide to Pharmacology - Targets
2278
OpenTargets
ENSG00000166483
ZINC - FDA approved
WEE1_HUMAN
ZINC - Substances
WEE1_HUMAN
ZINC - Biogenic
WEE1_HUMAN
ZINC target
P30291
PRO
P30291
PDB
2Z2W
,
3BIZ
,
5VC3
,
5VC4
,
7N3U
,
3CR0
,
5VD5
,
5VD7
,
5VDA
,
5V5Y
,
5VC5
,
3BI6
,
8BJU
,
5VC6
,
1X8B
,
5VD8
,
5VD9
,
5VD2
,
2IN6
,
2IO6
,
3CQE
,
5VD4
ZINC - Investigational
WEE1_HUMAN
GeneCards
P30291
HPA
ENSG00000166483-WEE1
Ensembl
ENSP00000402084
,
ENST00000299613
,
ENSP00000506667
,
ENST00000450114
,
ENSP00000299613
,
ENSG00000166483
,
ENST00000681684
Pharos - Targets
P30291
ZINC - Predictions - Purchasable
WEE1_HUMAN
HMDB Protein
HMDBP01212
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.796
5
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.763
5
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.734
5
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.671
4
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.667
5
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.604
3
UniProt:P53350 PLK1
4
PLK1 [nucleoplasm]
(R-HSA-156720)
p-T210-PLK1 [cytosol]
(R-HSA-3000318)
p-T210-PLK1 [nucleoplasm]
(R-HSA-3002800)
PLK1 [cytosol]
(R-HSA-164603)
0.59
2
UniProt:O95619 YEATS4
1
YEATS4 [nucleoplasm]
(R-HSA-3322940)
0.527
3
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.499
2
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