Reactome | UPF3B [nucleoplasm]

UPF3B [nucleoplasm]

Stable Identifier

R-HSA-156776

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

hUpf3B, UPf3B

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of mRNA at the 3'-end (Homo sapiens)
      - 3' end cleaved, ligated exon containing complex [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        UPF3B [nucleoplasm] (Homo sapiens)
      - Spliced mRNA:CBC:EJC:TREX [nucleoplasm] (Homo sapiens)
        
        EJC [nucleoplasm] (Homo sapiens)
        
        UPF3B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BZI7 UPF3B

Gene Names

UPF3B, RENT3B, UPF3X

Chain

chain:1-483

Reference Genes

BioGPS Gene:65109 UPF3B

COSMIC (genes):UPF3B UPF3B

CTD Gene:65109 UPF3B

dbSNP Gene:65109 UPF3B

ENSEMBL:ENSG00000125351 UPF3B

ENSEMBL_homo_sapiens_GENE:ENSG00000125351.14 UPF3B

HGNC:20439 UPF3B

KEGG Gene (Homo sapiens):65109 UPF3B

Monarch:65109 UPF3B

NCBI Gene:65109 UPF3B

OMIM:300298 UPF3B

UCSC:Q9BZI7 UPF3B

Reference Transcript

Other Identifiers

11723549_a_at

11751257_a_at

17113635

218757_PM_s_at

218757_s_at

2893364

4019575

4019576

4019577

4019578

4019580

4019583

4019584

4019586

4019587

4019589

4019590

4019592

4019595

4019596

65109

80832_s_at

8174717

A_23_P45409

A_24_P310630

GE63060

GO:0000184

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005815

GO:0005829

GO:0005856

GO:0007420

GO:0016071

GO:0030154

GO:0031175

GO:0034451

GO:0035145

GO:0043025

GO:0043226

GO:0045666

GO:0045727

GO:0048856

GO:0051028

GO:1905746

HMNXSV003040332

HMNXSV003046631

ILMN_1798163

ILMN_2397627

PH_hs_0005757

TC0X001315.hg

g12711673_3p_a_at

Participates

as a component of

as an input of

Formation of the Spliceosomal B* complex (Homo sapiens)

Other forms of this molecule

UPF3B [cytosol]

Inferred To

Upf3 [nucleoplasm] (Drosophila melanogaster)

Upf3b [nucleoplasm] (Mus musculus)

Upf3b [nucleoplasm] (Rattus norvegicus)

Ghost homologue of UPF3B [nucleoplasm] (Canis familiaris)

Ghost homologue of UPF3B [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of UPF3B [nucleoplasm] (Xenopus tropicalis)

upf3 [nucleoplasm] (Schizosaccharomyces pombe)

smg-4 [nucleoplasm] (Caenorhabditis elegans)

upf3b [nucleoplasm] (Danio rerio)

UPF3 [nucleoplasm] (Saccharomyces cerevisiae)

UPF3B [nucleoplasm] (Bos taurus)

UPF3B [nucleoplasm] (Dictyostelium discoideum)

UPF3B [nucleoplasm] (Gallus gallus)

UPF3B [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_075386.1, NP_542199.1

OpenTargets

ENSG00000125351

GeneCards

Q9BZI7

HPA

ENSG00000125351-UPF3B

Ensembl

ENSP00000245418, ENST00000276201, ENSP00000276201, ENST00000345865, ENSG00000125351

PRO

Q9BZI7

Pharos - Targets

Q9BZI7

Orphanet

17318

PDB

1UW4, 2XB2, 7NWU

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5S9 RBM8A	2	RBM8A [cytosol] (R-HSA-162462) RBM8A [nucleoplasm] (R-HSA-156659)	0.914	10
UniProt:Q9HAU5 UPF2	1	UPF2 [cytosol] (R-HSA-927799)	0.897	9
UniProt:Q92900 UPF1	2	UPF1 [cytosol] (R-HSA-927734) p-4S-UPF1 [cytosol] (R-HSA-927856)	0.886	11
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.883	9
UniProt:P61326 MAGOH	1	MAGOH [nucleoplasm] (R-HSA-156658)	0.773	7
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.643	3
UniProt:O15234 CASC3	2	CASC3 [cytosol] (R-HSA-927807) CASC3 [nucleoplasm] (R-HSA-8849148)	0.643	3
UniProt:Q92900-2 UPF1			0.527	2
UniProt:Q9UBU9 NXF1	2	NXF1 [cytosol] (R-HSA-156481) NXF1 [nucleoplasm] (R-HSA-111690)	0.527	2