Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
NEXT3 [plasma membrane]
Stable Identifier
R-HSA-157203
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
NOTCH3(1629-2321), Notch 3 NEXT fragment
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by NOTCH (Homo sapiens)
Signaling by NOTCH3 (Homo sapiens)
NOTCH3 Activation and Transmission of Signal to the Nucleus (Homo sapiens)
NEXT3 is cleaved to produce NICD3 (Homo sapiens)
NEXT3 [plasma membrane] (Homo sapiens)
NOTCH3 binds WWP2 (Homo sapiens)
NEXT3,NICD3 [cytosol] (Homo sapiens)
NEXT3 [plasma membrane] (Homo sapiens)
NEXT3,NICD3:WWP2 [cytosol] (Homo sapiens)
NEXT3,NICD3 [cytosol] (Homo sapiens)
NEXT3 [plasma membrane] (Homo sapiens)
NOTCH3-ligand complex is cleaved to produce NEXT3 (Homo sapiens)
NEXT3 [plasma membrane] (Homo sapiens)
WWP2 ubiquitinates NOTCH3 (Homo sapiens)
NEXT3,NICD3:WWP2 [cytosol] (Homo sapiens)
NEXT3,NICD3 [cytosol] (Homo sapiens)
NEXT3 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UM47 NOTCH3
Gene Names
NOTCH3
Chain
signal peptide:1-39, chain:40-2321, chain:1629-2321, chain:1662-2321
Reference Genes
BioGPS Gene:4854 NOTCH3
COSMIC (genes):NOTCH3 NOTCH3
CTD Gene:4854 NOTCH3
dbSNP Gene:4854 NOTCH3
ENSEMBL:ENSG00000074181 NOTCH3
HGNC:7883 NOTCH3
KEGG Gene (Homo sapiens):4854 NOTCH3
Monarch:4854 NOTCH3
NCBI Gene:4854 NOTCH3
OMIM:600276 NOTCH3
UCSC:Q9UM47 NOTCH3
Reference Transcript
RefSeq:NM_000435.2 NOTCH3
Other Identifiers
0001990315
11716569_at
11716570_a_at
16869769
203237_s_at
203238_s_at
3853111
3853112
3853113
3853114
3853115
3853116
3853117
3853118
3853119
3853120
3853121
3853122
3853123
3853124
3853126
3853127
3853128
3853129
3853130
3853131
3853133
3853134
3853135
3853136
3853137
3853138
3853139
3853140
3853141
3853142
3853143
3853145
3853146
3853147
3853148
3853150
3853151
3853152
3853153
3853154
3853157
3853158
3853159
3853160
3853161
3853162
3853163
3853164
3853166
3853167
3853168
3853169
3853170
3853173
3853174
3853175
38750_at
4854
8034940
A_33_P3313055
GE79373
GO:0000139
GO:0000902
GO:0003674
GO:0005509
GO:0005515
GO:0005575
GO:0005576
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005789
GO:0005794
GO:0005829
GO:0005856
GO:0005886
GO:0006355
GO:0006367
GO:0007165
GO:0007219
GO:0007221
GO:0007275
GO:0007411
GO:0008150
GO:0009058
GO:0009986
GO:0015629
GO:0016020
GO:0016021
GO:0030154
GO:0032991
GO:0034641
GO:0038023
GO:0040011
GO:0042802
GO:0043167
GO:0043226
GO:0043235
GO:0045296
GO:0045746
GO:0048856
GO:0050793
HMNXSV003010299
Hs.8546.0.A1_3p_a_at
ILMN_1658926
ILMN_1755832
PH_hs_0000907
TC19001250.hg
g4557798_3p_a_at
Participates
as a member of
NEXT3,NICD3 [cytosol] (Homo sapiens)
as an output of
NOTCH3-ligand complex is cleaved to produce NEXT3 (Homo sapiens)
as an input of
NEXT3 is cleaved to produce NICD3 (Homo sapiens)
Other forms of this molecule
Ub-NICD3 [cytosol]
Ub-NEXT3 [plasma membrane]
p-Y-NICD3 [cytosol]
Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane]
FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane]
NOTCH3(40-1628) [extracellular region]
NOTCH3(1629-1661) [plasma membrane]
NICD3 [cytosol]
NICD3 [nucleoplasm]
Pre-NOTCH3 [endoplasmic reticulum membrane]
10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane]
NOTCH3(1572-2321) [plasma membrane]
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region]
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane]
NOTCH3(1572-2321) [Golgi membrane]
Inferred To
NOTCH1 [plasma membrane]
(Gallus gallus)
Notch3 [plasma membrane]
(Mus musculus)
Notch3 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_000426.2
Guide to Pharmacology - Targets
2860
OpenTargets
ENSG00000074181
ZINC - Substances
NOTC3_HUMAN
ZINC target
Q9UM47
PRO
Q9UM47
GlyGen
Q9UM47
PDB
4ZLP
,
5CZX
,
6WQU
,
5CZV
,
6XSW
GeneCards
Q9UM47
HPA
ENSG00000074181-NOTCH3
Ensembl
ENSG00000074181
,
ENST00000263388
,
ENSP00000263388
Pharos - Targets
Q9UM47
ZINC - Predictions - Purchasable
NOTC3_HUMAN
Orphanet
16559
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UM47 NOTCH3
20
Ub-NICD3 [cytosol]
(R-HSA-9021546)
Ub-NEXT3 [plasma membrane]
(R-HSA-9021545)
p-Y-NICD3 [cytosol]
(R-HSA-9018581)
Glc,GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911429)
Glc,Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911419)
Glc,Sia-Gal-GlcNAc-Fuc-Pre-NOTCH3 [Golgi membrane]
(R-HSA-1911504)
FRINGE-modified NOTCH3 Extracellular Fragment (NECD3) [plasma membrane]
(R-HSA-1911517)
FRINGE-modified NOTCH3 Extracellular fragment (NECD3) [Golgi membrane]
(R-HSA-1911522)
NOTCH3(40-1628) [extracellular region]
(R-HSA-157639)
NOTCH3(1629-1661) [plasma membrane]
(R-HSA-157657)
NEXT3 [plasma membrane]
(R-HSA-157203)
NICD3 [cytosol]
(R-HSA-157647)
NICD3 [nucleoplasm]
(R-HSA-157928)
Pre-NOTCH3 [endoplasmic reticulum membrane]
(R-HSA-157102)
10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
(R-HSA-1467382)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [endoplasmic reticulum membrane]
(R-HSA-1467307)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-2321) [Golgi membrane]
(R-HSA-1472871)
NOTCH3(1572-2321) [plasma membrane]
(R-HSA-157231)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [extracellular region]
(R-HSA-1983675)
14xGlcS-10xFucT-4xFucS-NOTCH3(40-1571) [Golgi membrane]
(R-HSA-1983672)
0.558
2
UniProt:P86480 PR20D
0.556
3
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.527
2
UniProt:Q9R1P4 Psma1
2
Proteasome subunit alpha type-1 [nucleoplasm]
(R-MMU-9008778)
Proteasome subunit alpha type-1 [cytosol]
(R-MMU-1236802)
0.508
2
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text