Reactome | PPP2R5E [cytosol]

PPP2R5E [cytosol]

Stable Identifier

R-HSA-1638770

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PP2A -56 kDa regulatory subunit B epsilon isoform

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle Checkpoints (Homo sapiens)
  - Mitotic Spindle Checkpoint (Homo sapiens)
    - Amplification of signal from the kinetochores (Homo sapiens)
      - Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (Homo sapiens)
        
        MAD2 associates with the Mad1 kinetochore complex (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        MAD2 converted to an inhibitory state via interaction with Mad1 (Homo sapiens)
        
        Kinetochore:Mad1:MAD2 Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Mad1 binds kinetochore (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Release of activated MAD2 from kinetochores (Homo sapiens)
        
        Kinetochore:Mad1:MAD2* Complex [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Mad1:kinetochore complex [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Separation of Sister Chromatids (Homo sapiens)
        
        ESPL1 (Separase) cleaves centromeric cohesin (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Separation of sister chromatids (Homo sapiens)
        
        Cleaved Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore:Microtubules [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
    - Mitotic Prometaphase (Homo sapiens)
      - EML4 and NUDC in mitotic spindle formation (Homo sapiens)
        
        EML4 recruits NUDC to mitotic spindle (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        p-S274,S326-NUDC:EML4 homotrimer:Microtubule-bound kinetochore [spindle] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - Kinetochore capture of astral microtubules (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - Resolution of Sister Chromatid Cohesion (Homo sapiens)
        
        CDK1 phosphorylates CDCA5 (Sororin) at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Kinetochore assembly (Homo sapiens)
        
        Ac-Cohesin:PDS5:CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Ac-Cohesin:PDS5:WAPAL:Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Sister Centromere:Kinetochore [chromosome, centromeric region] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        PP2A-B56 dephosphorylates centromeric cohesin (Homo sapiens)
        
        p-RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Phosphorylation of cohesin by PLK1 at centromeres (Homo sapiens)
        
        Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        p-STAG2,RAD21-Ac-Cohesin:PDS5:p-CDCA5:WAPAL:Sister Centromeres:Kinetochores:Microtubules [chromosome, centromeric region] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)

Hemostasis (Homo sapiens)

- Platelet homeostasis (Homo sapiens)
  - Platelet sensitization by LDL (Homo sapiens)
    - PECAM-1 binds PP2A (Homo sapiens)
      - PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - p-PECAM:PP2A [plasma membrane] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling (Homo sapiens)
        
        Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307 (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        p-Y307-PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - Negative regulation of MAPK pathway (Homo sapiens)
        
        PP2A dephosphorylates RAF1 (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - RAF activation (Homo sapiens)
        
        PP2A dephosphorylates KSR1 (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        PP2A dephosphorylates inactive RAFs (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase Effectors (Homo sapiens)
      - RHO GTPases Activate Formins (Homo sapiens)
        
        AURKB phosphorylates DIAPH2-2 at kinetochores (Homo sapiens)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        CDC42:GTP recruits DIAPH2-2 to kinetochores (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Kinetochore:CDC42:GTP:DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Kinetochore capture of astral microtubules is positively regulated by CDC42:GTP:p-S196-DIAPH2-2 (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Kinetochore:CDC42:GTP:p-S196-DIAPH2-2 [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        Microtubule-bound kinetochore [cytosol] (Homo sapiens)
        
        Kinetochore [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
- Signaling by WNT (Homo sapiens)
  - Degradation of beta-catenin by the destruction complex (Homo sapiens)
    - AXIN is phosphorylated in the destruction complex (Homo sapiens)
      - AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
    - Assembly of the destruction complex (Homo sapiens)
      - AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
    - Association of beta-catenin with the RBX1:SCF(beta-TrCP1) ubiquitin ligase complex (Homo sapiens)
      - RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
    - Association of beta-catenin with the destruction complex (Homo sapiens)
      - CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
    - Beta-catenin phosphorylation cascade (Homo sapiens)
      - Phosphorylation of beta-catenin at Ser45 by CK1 alpha (Homo sapiens)
        
        CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3 (Homo sapiens)
        
        p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3 (Homo sapiens)
        
        p-S45 CTNNB1:p-Axin:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        p-T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3 (Homo sapiens)
        
        p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        p-S37,T41,S45 CTNNB1:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
    - Degradation of ubiquitinated beta catenin by the proteasome (Homo sapiens)
      - p-AXIN:CK1alpha:GSK3B:phospho-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
        
        RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
    - Dissociation of beta-catenin from Axin and association of beta catenin with phospho-(20 aa) APC in the detruction complex (Homo sapiens)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
    - Multi-ubiquitination of phospho-beta-catenin by RBX1:SCF(beta-TrCP1) (Homo sapiens)
      - RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - ubiquitinated phospho-beta-catenin:RBX1:SCF(beta-TrCP1) complex [cytosol] (Homo sapiens)
        
        RBX1:SKP1:CUL1:beta-TrCP1:phosphorylated beta-catenin complex [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
    - Phosphorylation of APC component of the destruction complex (Homo sapiens)
      - p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - p-S33,S37,T41,S45-beta-catenin:p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        p-AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
  - TCF dependent signaling in response to WNT (Homo sapiens)
    - Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
      - Beta-catenin is released from the destruction complex (Homo sapiens)
        
        CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
      - PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)
        
        CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)
        
        p-S33,S37,T41,S45 CTNNB1:p-AXIN:CK1alpha:GSK3B:phospho-ub-APC (20 aa repeat region):PP2A:AMER1 complex [cytosol] (Homo sapiens)
        
        PP2A [cytosol] (Homo sapiens)
        
        PP2A regulatory subunit B56 [cytosol] (Homo sapiens)
        
        PPP2R5E [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16537 PPP2R5E

Gene Names

PPP2R5E

Chain

initiator methionine:, chain:2-467

Reference Genes

BioGPS Gene:5529 PPP2R5E

COSMIC (genes):PPP2R5E PPP2R5E

CTD Gene:5529 PPP2R5E

dbSNP Gene:5529 PPP2R5E

ENSEMBL:ENSG00000154001 PPP2R5E

HGNC:9313 PPP2R5E

KEGG:hsa:5529 PPP2R5E

Monarch:5529 PPP2R5E

NCBI Gene:5529 PPP2R5E

OMIM:601647 PPP2R5E

UCSC:Q16537 PPP2R5E

Reference Transcript

Other Identifiers

11730271_at

11730272_a_at

11748296_a_at

11748297_s_at

11759023_at

11759024_at

11759025_s_at

16793721

203338_PM_at

203338_at

227630_PM_at

227630_at

228070_PM_at

228070_at

229322_PM_at

229322_at

2361184

3051984

3051987

3051990

3051991

3051992

32734_at

3567985

3567986

3567987

3567988

3567989

3567990

3567992

3567993

3567994

3567995

3567996

3567997

3567998

3568005

3568009

3568017

3568018

3568019

3568035

3568036

3568037

3568038

3568039

3568040

3568041

3568049

3568050

3568051

53735_at

5529

56629_at

56638_g_at

76264_at

7979551

A_23_P3042

A_24_P5026

GE57793

GO:0000159

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0007165

GO:0019888

GO:0043226

GO:0072542

GO:0098772

HMNXSV003032848

Hs.122684.1.S1_3p_at

Hs.283362.0.A1_3p_at

Hs.319817.0.A1_3p_at

ILMN_1666761

L76703_at

PH_hs_0027933

TC14001206.hg

g5453955_3p_at

Participates

as a candidate of

PP2A regulatory subunit B56 [cytosol] (Homo sapiens)

Inferred To

ppp2r5e [cytosol] (Xenopus tropicalis)

par1 [cytosol] (Schizosaccharomyces pombe)

Homologues of PPP2R5E [cytosol] (Schizosaccharomyces pombe)

PPP2R5E [cytosol] (Bos taurus)

PPP2R5E [cytosol] (Canis familiaris)

PPP2R5E [cytosol] (Gallus gallus)

PPP2R5E [cytosol] (Sus scrofa)

Ppp2r5e [cytosol] (Mus musculus)

Ppp2r5e [cytosol] (Rattus norvegicus)

psrA [cytosol] (Dictyostelium discoideum)

RTS1 [cytosol] (Saccharomyces cerevisiae)

par2 [cytosol] (Schizosaccharomyces pombe)

wdb [cytosol] (Drosophila melanogaster)

pptr-1 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001269110.1, NP_006237.1, NP_001269111.1, NP_001269108.1, NP_001269109.1

ENSEMBL

ENST00000422769, ENSP00000452396, ENSP00000337641, ENST00000337537, ENSP00000404632, ENST00000555899

OpenTargets

ENSG00000154001

HPA

ENSG00000154001-PPP2R5E

PRO

Q16537

Pharos - Targets

Q16537

PDB

8UWB

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P67775 PPP2CA	4	PPP2CA [cytosol] (R-HSA-165971) PPP2CA [nucleoplasm] (R-HSA-165978) p-Y307-PPP2CA [cytosol] (R-HSA-8857939) MeL-PPP2CA [nucleoplasm] (R-HSA-8857791)	0.855	7
UniProt:Q9H0H5 RACGAP1	1	RACGAP1 [cytosol] (R-HSA-195122)	0.593	5
UniProt:Q86YF9 DZIP1	1	DZIP1 [nucleoplasm] (R-HSA-5635020)	0.581	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	15
UniProt:Q99677 LPAR4	1	LPAR4 [plasma membrane] (R-HSA-418020)	0.527	2
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.527	2
UniProt:P51959 CCNG1	1	CCNG1 [nucleoplasm] (R-HSA-6792489)	0.527	2
UniProt:P56704 WNT3A	10	N4GlycoAsn-PalmS WNT3A [plasma membrane] (R-HSA-3247807) N4GlycoAsn-PalmS WNT3A [extracellular region] (R-HSA-3247784) N4GlycoAsn-PalmS WNT3A [Golgi lumen] (R-HSA-3247832) N4GlycoAsn-PalmS WNT3A [endoplasmic reticulum lumen] (R-HSA-3238344) N4GlycoAsn-WNT3A [endoplasmic reticulum lumen] (R-HSA-3238231) WNT3A [endoplasmic reticulum lumen] (R-HSA-3238292) N4GlycoAsn-PalmS WNT3A [early endosome membrane] (R-HSA-5368483) N4GlycoAsn-PalmS WNT3A [endocytic vesicle membrane] (R-HSA-3781944) N4GlycoAsn-PalmS WNT3A [extracellular exosome] (R-HSA-3781968) WNT3A [extracellular region] (R-HSA-201710)	0.527	3
UniProt:Q9HC29 NOD2	1	NOD2 [cytosol] (R-HSA-168411)	0.508	2
UniProt:O96017 CHEK2	3	p-S,3T-CHEK2 [nucleoplasm] (R-HSA-5683784) CHEK2 [nucleoplasm] (R-HSA-113824) p-T68-CHEK2 [nucleoplasm] (R-HSA-113825)	0.508	3
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2

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