Reactome | CPSF4 [nucleoplasm]

CPSF4 [nucleoplasm]

Stable Identifier

R-HSA-169104

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

CPSF30, Cleavage and polyadenylation specificity factor subunit 4, Cleavage and polyadenylation specificity factor 30 kDa subunit, NEB1, NAR

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - RNA Polymerase II Transcription Termination (Homo sapiens)
    - Cleavage of Intronless Pre-mRNA at 3'-end (Homo sapiens)
      - intronless pre-mRNA cleavage complex [nucleoplasm] (Homo sapiens)
        
        CstF:CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF:capped intronless pre-mRNA:CBC complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF4 [nucleoplasm] (Homo sapiens)
      - upstream mRNA fragment:CPSF:PAP:PABPN1 complex [nucleoplasm] (Homo sapiens)
        
        CPSF [nucleoplasm] (Homo sapiens)
        
        CPSF4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95639 CPSF4

Gene Names

CPSF4, CPSF30, NAR, NEB1

Chain

chain:1-269

Reference Genes

BioGPS Gene:10898 CPSF4

COSMIC - genes:CPSF4 CPSF4

CTD Gene:10898 CPSF4

dbSNP Gene:10898 CPSF4

ENSEMBL:ENSG00000160917 CPSF4

HGNC:2327 CPSF4

KEGG:hsa:10898 CPSF4

Monarch:10898 CPSF4

NCBI Gene:10898 CPSF4

OMIM:603052 CPSF4

UCSC:O95639 CPSF4

Reference Transcript

Participates

as a component of

as an input of

Inferred To

yth1 [nucleoplasm] (Schizosaccharomyces pombe)

Clp [nucleoplasm] (Drosophila melanogaster)

YTH1 [nucleoplasm] (Saccharomyces cerevisiae)

Cpsf4 [nucleoplasm] (Mus musculus)

Cpsf4 [nucleoplasm] (Rattus norvegicus)

cpsf-4 [nucleoplasm] (Caenorhabditis elegans)

CPSF4 [nucleoplasm] (Bos taurus)

CPSF4 [nucleoplasm] (Canis familiaris)

CPSF4 [nucleoplasm] (Gallus gallus)

CPSF4 [nucleoplasm] (Sus scrofa)

cpsf4 [nucleoplasm] (Danio rerio)

cpsf4 [nucleoplasm] (Dictyostelium discoideum)

cpsf4 [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001075028.1, NP_001305091.1, NP_006684.1, NP_001305089.1, NP_001305090.1

OpenTargets

ENSG00000160917

ENSEMBL

ENST00000436336, ENSP00000395311, ENST00000292476, ENSG00000160917, ENSP00000292476

HPA

ENSG00000160917-CPSF4

GeneCards

CPSF4

PRO

O95639

Pharos - Targets

O95639

GlyGen

O95639

PDB

8R8R, 2RHK, 6URO, 6URG, 8E3Q, 8E3I, 7K95, 6DNH, 6FUW, 2D9N, 7ZYH

Interactors (14)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6UN15 FIP1L1	9	FIP1L1 [nucleoplasm] (R-HSA-6805150) FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9672499) FIP1L1(1-272)-PDGFRA(567-1089) fusion [cytosol] (R-HSA-9672496) FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol] (R-HSA-9672502) FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol] (R-HSA-9672506) p-11Y-FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol] (R-HSA-9673872) p-11Y-FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol] (R-HSA-9673621) p-11Y-FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol] (R-HSA-9673879) p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol] (R-HSA-9673867)	0.659	5
UniProt:Q9UKF6 CPSF3	2	Ub-K63-CPSF3 [nucleoplasm] (R-HSA-9970273) CPSF3 [nucleoplasm] (R-HSA-71993)	0.643	4
UniProt:Q10570 CPSF1	1	CPSF1 [nucleoplasm] (R-HSA-71989)	0.564	2
UniProt:P50222 MEOX2			0.556	3
IntAct:EBI-10185891 81608			0.556	3
UniProt:Q9C0J8 WDR33	1	WDR33 [nucleoplasm] (R-HSA-8938784)	0.527	5
UniProt:Q92797 SYMPK	1	SYMPK [nucleoplasm] (R-HSA-4615988)	0.527	3
UniProt:O15460 P4HA2	1	P4HA2 [endoplasmic reticulum lumen] (R-HSA-2980974)	0.527	2
UniProt:Q6P1J9 CDC73	1	CDC73 [nucleoplasm] (R-HSA-3322360)	0.499	3
UniProt:I6T1Z2 I6T1Z2			0.499	5
UniProt:Q194T2 Q194T2			0.499	5
UniProt:Q16629 SRSF7	1	SRSF7 [nucleoplasm] (R-HSA-72029)	0.483	2
UniProt:P06748 NPM1	11	NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [granular component] (R-HSA-9017702) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039)	0.483	2
UniProt:Q16630 CPSF6	2	CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838987) CPSF6(1-490)-FGFR1(429-822) fusion [cytosol] (R-HSA-1614368)	0.483	2

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