Reactome | Synthesis of pyrophosphates in the cytosol

Synthesis of pyrophosphates in the cytosol

Stable Identifier

R-HSA-1855167

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Synthesis of pyrophosphates in the cytosol

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Inositol phosphates such as IP4, IP5 and IP6 are converted to an even wider variety of IPs including the di- and triphospho inositol phosphates, also known as pyrophosphates (Irvine & Schell 2001, Alcazar-Romain & Wente 2008, York 2006, Monserrate and York 2010, Ho et al. 2002, Saiardi et al. 2001, Draskovic et al. 2008, Choi et al. 2007, Caffrey et al. 2000, Leslie et al. 2002).

Literature References

PubMed ID	Title	Journal	Year
20359876	Inositol phosphate synthesis and the nuclear processes they affect Monserrate, JP, York, JD	Curr Opin Cell Biol	2010
17943301	Inositol polyphosphates: a new frontier for regulating gene expression Wente, SR, Alcázar-Román, AR	Chromosoma	2008
11331907	Back in the water: the return of the inositol phosphates Schell, MJ, Irvine, RF	Nat Rev Mol Cell Biol	2001
18355727	Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups Ilc, G, Bhandari, R, Burton, A, Kovacevic, M, Saiardi, A, Podobnik, M, Snyder, SH, Draskovic, P	Chem Biol	2008
12121577	Cloning and characterisation of hAps1 and hAps2, human diadenosine polyphosphate-metabolising Nudix hydrolases Safrany, ST, Leslie, NR, McLennan, AG	BMC Biochem	2002
11502751	Identification and characterization of a novel inositol hexakisphosphate kinase Nagata, E, Saiardi, A, Snyder, SH, Snowman, AM, Luo, HR	J Biol Chem	2001
10777568	Discovery of molecular and catalytic diversity among human diphosphoinositol-polyphosphate phosphohydrolases. An expanding Nudt family Safrany, ST, Caffrey, JJ, Yang, X, Shears, SB	J Biol Chem	2000
17702752	Purification, sequencing, and molecular identification of a mammalian PP-InsP5 kinase that is activated when cells are exposed to hyperosmotic stress Cho, J, Williams, J, Falck, JR, Choi, JH, Shears, SB	J Biol Chem	2007
16781889	Regulation of nuclear processes by inositol polyphosphates York, JD	Biochim Biophys Acta	2006
11909533	Regulation of Ins(3,4,5,6)P(4) signaling by a reversible kinase/phosphatase Zhang, T, Kwon, YU, Potter, BV, Carew, MA, Chung, SK, Riley, AM, Vogel, G, Hua, L, Ho, MW, Yang, X, Shears, SB, Adelt, S	Curr Biol	2002