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RPS6KA2 [nucleoplasm]
Stable Identifier
R-HSA-199861
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Ribosomal protein S6 kinase alpha 2, K6A2_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Senescence-Associated Secretory Phenotype (SASP) (Homo sapiens)
ERK1/2/5 activate RSK1/2/3 (Homo sapiens)
Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
RPS6KA2 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK1/2/5 activate RSK1/2/3 (Homo sapiens)
Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
RPS6KA2 [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK1/2/5 activate RSK1/2/3 (Homo sapiens)
Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
RPS6KA2 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK1/2/5 activate RSK1/2/3 (Homo sapiens)
Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
RPS6KA2 [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK1/2/5 activate RSK1/2/3 (Homo sapiens)
Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
RPS6KA2 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK1/2/5 activate RSK1/2/3 (Homo sapiens)
Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
RPS6KA2 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK1/2/5 activate RSK1/2/3 (Homo sapiens)
Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
RPS6KA2 [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK1/2/5 activate RSK1/2/3 (Homo sapiens)
Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
RPS6KA2 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK1/2/5 activate RSK1/2/3 (Homo sapiens)
Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
RPS6KA2 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK1/2/5 activate RSK1/2/3 (Homo sapiens)
Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
RPS6KA2 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK1/2/5 activate RSK1/2/3 (Homo sapiens)
Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
RPS6KA2 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Gastrin-CREB signalling pathway via PKC and MAPK (Homo sapiens)
ERK1/2/5 activate RSK1/2/3 (Homo sapiens)
Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
RPS6KA2 [nucleoplasm] (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
ERK/MAPK targets (Homo sapiens)
ERK1/2/5 activate RSK1/2/3 (Homo sapiens)
Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
RPS6KA2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15349 RPS6KA2
Gene Names
RPS6KA2, MAPKAPK1C, RSK3
Chain
chain:1-733
Reference Genes
BioGPS Gene:6196 RPS6KA2
COSMIC (genes):RPS6KA2 RPS6KA2
CTD Gene:6196 RPS6KA2
dbSNP Gene:6196 RPS6KA2
ENSEMBL:ENSG00000071242 RPS6KA2
ENSEMBL_homo_sapiens_GENE:ENSG00000071242.12 RPS6KA2
HGNC:10431 RPS6KA2
KEGG Gene (Homo sapiens):6196 RPS6KA2
Monarch:6196 RPS6KA2
NCBI Gene:6196 RPS6KA2
OMIM:601685 RPS6KA2
UCSC:Q15349 RPS6KA2
Reference Transcript
RefSeq:NM_001318937.1 RPS6KA2
RefSeq:NM_001318936.1 RPS6KA2
RefSeq:NM_021135.5 RPS6KA2
RefSeq:NM_001006932.2 RPS6KA2
RefSeq:NM_001318938.1 RPS6KA2
Other Identifiers
11731762_s_at
11731763_s_at
11743831_s_at
11756657_a_at
1557970_PM_s_at
1557970_s_at
204906_PM_at
204906_at
212912_PM_at
212912_at
2984665
2984666
2984667
2984668
2984669
2984670
2984671
2984672
2984673
2984674
2984675
2984677
2984678
2984679
2984680
2984683
2984685
2984695
2984697
2984698
2984703
2984720
2984722
2984730
2984733
2984736
2984743
2984744
2984754
2984759
2984786
2984787
2984810
2984811
2984812
2984813
2984814
2984936
32892_at
33325_at
54736_at
6196
8130739
A_23_P335920
A_33_P3347452
A_33_P3399935
A_33_P3399943
GE82591
GE86143
GO:0000166
GO:0000287
GO:0001556
GO:0002035
GO:0003013
GO:0003824
GO:0004672
GO:0004674
GO:0004711
GO:0004712
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005819
GO:0005829
GO:0005856
GO:0006468
GO:0007165
GO:0007268
GO:0007507
GO:0008285
GO:0010628
GO:0010659
GO:0012501
GO:0016301
GO:0016310
GO:0016740
GO:0022414
GO:0023052
GO:0030154
GO:0035556
GO:0036211
GO:0043065
GO:0043226
GO:0045202
GO:0045786
GO:0045835
GO:0046872
GO:0048856
GO:0050877
GO:0050886
GO:0051604
GO:0060047
GO:0070613
GO:0071322
GO:0072687
GO:0106310
GO:0140013
GO:0140096
HMNXSV003031331
Hs.184581.0.A1_3p_at
Hs2.397210.1.S1_3p_s_at
ILMN_1702501
ILMN_1790801
PH_hs_0015556
TC06004057.hg
X85106_at
g12803118_3p_at
Participates
as a member of
Ribosomal protein S6 kinase [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-4S,T356,T570-RPS6KA2 [nucleoplasm]
RPS6KA2 [cytosol]
p-T356,S360,T570-RPS6KA2 [cytosol]
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol]
p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm]
Inferred To
RPS6KA2 [nucleoplasm]
(Bos taurus)
RPS6KA2 [nucleoplasm]
(Caenorhabditis elegans)
RPS6KA2 [nucleoplasm]
(Canis familiaris)
RPS6KA2 [nucleoplasm]
(Dictyostelium discoideum)
RPS6KA2 [nucleoplasm]
(Drosophila melanogaster)
RPS6KA2 [nucleoplasm]
(Gallus gallus)
RPS6KA2 [nucleoplasm]
(Mus musculus)
RPS6KA2 [nucleoplasm]
(Rattus norvegicus)
RPS6KA2 [nucleoplasm]
(Saccharomyces cerevisiae)
RPS6KA2 [nucleoplasm]
(Schizosaccharomyces pombe)
RPS6KA2 [nucleoplasm]
(Sus scrofa)
RPS6KA2 [nucleoplasm]
(Xenopus tropicalis)
Cross References
RefSeq
NP_066958.2
,
NP_001006933.2
,
NP_001305867.1
,
NP_001305865.1
,
NP_001305866.1
ZINC - World Drugs
KS6A2_HUMAN
Guide to Pharmacology - Targets
1529
OpenTargets
ENSG00000071242
ZINC - FDA approved
KS6A2_HUMAN
ZINC - Substances
KS6A2_HUMAN
ZINC - Biogenic
KS6A2_HUMAN
ZINC target
Q15349
PRO
Q15349
ZINC - Investigational
KS6A2_HUMAN
IntEnz
2.7.11.1
GeneCards
Q15349
HPA
ENSG00000071242-RPS6KA2
Ensembl
ENST00000503859
,
ENST00000265678
,
ENSP00000427015
,
ENSG00000071242
,
ENSP00000265678
Pharos - Targets
Q15349
ZINC - Predictions - Purchasable
KS6A2_HUMAN
HMDB Protein
HMDBP01159
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P28482 MAPK1
18
MAPK1 [endoplasmic reticulum lumen]
(R-HSA-9636293)
MAPK1 [azurophil granule lumen]
(R-HSA-6799225)
MAPK1 [extracellular region]
(R-HSA-6806250)
MAPK1 [ficolin-1-rich granule lumen]
(R-HSA-6800964)
p-T185,Y187 MAPK1 E322V [cytosol]
(R-HSA-9652797)
p-T185,Y187 MAPK1 E322K [cytosol]
(R-HSA-9652175)
p-T185,Y187 MAPK1 E81K [cytosol]
(R-HSA-9652799)
p-T185,Y187 MAPK1 S142L [cytosol]
(R-HSA-9652808)
p-T185,Y187 MAPK1 P58L [cytosol]
(R-HSA-9652806)
p-T185,Y187 MAPK1 D321V [cytosol]
(R-HSA-9652791)
p-T185,Y187 MAPK1 D321N [cytosol]
(R-HSA-9652785)
p-T185,Y187 MAPK1 E322A [cytosol]
(R-HSA-9652794)
p-T185,Y187 MAPK1 P58G [cytosol]
(R-HSA-9652802)
p-T185-MAPK1 [cytosol]
(R-HSA-9635773)
MAPK1 [nucleoplasm]
(R-HSA-199960)
MAPK1 [cytosol]
(R-HSA-59282)
p-T185,Y187-MAPK1 [cytosol]
(R-HSA-109853)
p-T185,Y187-MAPK1 [nucleoplasm]
(R-HSA-112354)
0.914
12
UniProt:Q14160 SCRIB
1
SCRIB [cytosol]
(R-HSA-4608858)
0.769
9
UniProt:Q15418 RPS6KA1
7
RPS6KA1 [nucleoplasm]
(R-HSA-199860)
p-4S,T359,T573-RPS6KA1 [nucleoplasm]
(R-HSA-199829)
RPS6KA1 [cytosol]
(R-HSA-444256)
p-T359,S363,T573-RPS6KA1 [cytosol]
(R-HSA-9619957)
p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619871)
p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol]
(R-HSA-9619993)
p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm]
(R-HSA-444292)
0.725
5
UniProt:P27361 MAPK3
6
MAPK3 [endoplasmic reticulum lumen]
(R-HSA-9636295)
p-T202-MAPK3 [cytosol]
(R-HSA-9635775)
MAPK3 [nucleoplasm]
(R-HSA-73724)
MAPK3 [cytosol]
(R-HSA-59284)
p-T202,Y204-MAPK3 [cytosol]
(R-HSA-109842)
p-T202,Y204-MAPK3 [nucleoplasm]
(R-HSA-112359)
0.706
5
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:Q12849 GRSF1
2
GRSF1 [mitochondrial matrix]
(R-HSA-9837006)
GRSF1 [cytosol]
(R-HSA-192689)
0.527
2
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