Reactome | CSNK2B [nucleoplasm]

CSNK2B [nucleoplasm]

Stable Identifier

R-HSA-6805067

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Casein kinase II beta subunit

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
      - Respiratory syncytial virus (RSV) genome replication, transcription and translation (Homo sapiens)
        
        Maturation of hRSV A proteins (Homo sapiens)
        
        M dimer is phosphorylated (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSNK2B [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
        
        CK2 binds FACT (Homo sapiens)
        
        CK2:FACT [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSNK2B [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSNK2B [nucleoplasm] (Homo sapiens)
        
        CK2:FACT phosphorylates TP53 (Homo sapiens)
        
        CK2:FACT [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSNK2B [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSNK2B [nucleoplasm] (Homo sapiens)
    - Transcriptional regulation by RUNX1 (Homo sapiens)
      - RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known (Homo sapiens)
        
        RUNX1 binds PRC1 complexes (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.5 [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSNK2B [nucleoplasm] (Homo sapiens)
        
        RUNX1:CBFB:(PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        (PRC1.4,PRC1.5) [nucleoplasm] (Homo sapiens)
        
        PRC1.5 [nucleoplasm] (Homo sapiens)
        
        Casein kinase II [nucleoplasm] (Homo sapiens)
        
        CSNK2B [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P67870 CSNK2B

Gene Names

CSNK2B, CK2N, G5A

Chain

initiator methionine:, chain:2-215

Reference Genes

BioGPS Gene:1460 CSNK2B

COSMIC (genes):CSNK2B CSNK2B

CTD Gene:1460 CSNK2B

dbSNP Gene:1460 CSNK2B

ENSEMBL:ENSG00000204435 CSNK2B

HGNC:2460 CSNK2B

KEGG:hsa:1460 CSNK2B

Monarch:1460 CSNK2B

NCBI Gene:1460 CSNK2B

OMIM:115441 CSNK2B

UCSC:P67870 CSNK2B

Reference Transcript

Other Identifiers

11723718_a_at

11737947_s_at

11745786_a_at

11747530_a_at

11757576_x_at

11760180_at

11760181_a_at

1460

17006763

17027898

17030721

17033428

17035519

17038221

17040816

201390_PM_s_at

201390_s_at

231777_PM_at

231777_at

2902560

2902561

2902562

2902563

2902564

2902565

2902566

2902567

2902568

2902569

2902570

2902571

2902572

2902573

2902575

2902576

2902577

2902578

2902579

2902581

2902582

2902583

2902584

410_s_at

55988_at

8118218

8118228

8178050

8178059

8179298

A_14_P200179

A_23_P59130

A_24_P804263

A_24_P97931

A_33_P3318027

GE59734

GE82605

GO:0000785

GO:0003682

GO:0003824

GO:0004674

GO:0005102

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0005956

GO:0007165

GO:0008285

GO:0016055

GO:0016301

GO:0016605

GO:0016740

GO:0018107

GO:0019887

GO:0019904

GO:0030674

GO:0031519

GO:0032435

GO:0032927

GO:0033211

GO:0034774

GO:0042802

GO:0043226

GO:0043537

GO:0046872

GO:0051101

GO:0060090

GO:0060391

GO:0061154

GO:0061629

GO:0065003

GO:0070062

GO:0075342

GO:0098772

GO:0140096

GO:1903901

GO:1904813

HMNXSV003021467

HMNXSV003049073

Hs.73527.0.S2_3p_at

ILMN_1785527

ILMN_1800461

PH_hs_0022181

TC06004074.hg

TC6_cox_hap2000242.hg

TC6_cox_hap2000243.hg

TC6_dbb_hap3000219.hg

TC6_dbb_hap3000220.hg

TC6_mann_hap4000193.hg

TC6_mann_hap4000194.hg

TC6_mcf_hap5000210.hg

TC6_mcf_hap5000211.hg

TC6_qbl_hap6000222.hg

TC6_qbl_hap6000223.hg

TC6_ssto_hap7000196.hg

TC6_ssto_hap7000197.hg

X57152_rna1_s_at

g10334850_3p_s_at

Participates

as a component of

Casein kinase II [nucleoplasm] (Homo sapiens)

This entity regulates

Negatively

CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90 (Homo sapiens)

Other forms of this molecule

CSNK2B [cytosol]

CSNK2B [ficolin-1-rich granule lumen]

CSNK2B [extracellular region]

CSNK2B [secretory granule lumen]

Inferred To

csnk2b [nucleoplasm] (Dictyostelium discoideum)

csnk2b [nucleoplasm] (Xenopus tropicalis)

CkIIbeta [nucleoplasm] (Drosophila melanogaster)

CSNK2B [nucleoplasm] (Bos taurus)

CSNK2B [nucleoplasm] (Canis familiaris)

CSNK2B [nucleoplasm] (Plasmodium falciparum)

CSNK2B [nucleoplasm] (Rattus norvegicus)

CSNK2B [nucleoplasm] (Sus scrofa)

Csnk2b [nucleoplasm] (Mus musculus)

CKB2 [nucleoplasm] (Saccharomyces cerevisiae)

kin-10 [nucleoplasm] (Caenorhabditis elegans)

ckb1 [nucleoplasm] (Schizosaccharomyces pombe)

Ghost homologue of CSNK2B [nucleoplasm] (Gallus gallus)

Cross References

RefSeq

NP_001269314.1, NP_001311.3

Guide to Pharmacology - Targets

1551

OpenTargets

ENSG00000204435

ENSEMBL

ENSP00000410802, ENSP00000394855, ENST00000431476, ENSP00000415237, ENST00000375866, ENST00000436169, ENSP00000372925, ENST00000448596, ENSP00000412520, ENST00000375865, ENST00000383433, ENST00000455161, ENST00000451917, ENST00000453234, ENSP00000365026, ENST00000452985, ENSP00000382980, ENSP00000365042, ENSP00000395275, ENSG00000230700, ENSP00000393756, ENSP00000391038, ENST00000418230, ENSP00000407379, ENSP00000407018, ENSP00000400188, ENSP00000390900, ENSP00000409510, ENST00000383427, ENST00000422567, ENST00000429633, ENST00000400110, ENSG00000204435, ENST00000412802, ENSP00000365025, ENST00000454382, ENSP00000415303, ENST00000443673, ENSP00000411322, ENSP00000413469, ENST00000458330, ENST00000375882, ENSG00000232960, ENSG00000206406, ENSP00000372919, ENSG00000224774, ENSG00000224398, ENST00000454511, ENSG00000228875

GeneCards

CSNK2B

HPA

ENSG00000204435-CSNK2B

PRO

P67870

Pharos - Targets

P67870

GlyGen

P67870

Orphanet

CSNK2B

HMDB Protein

HMDBP10475

PDB

3EED, 1QF8, 4NH1, 1DS5, 6Q38, 4MD8, 4MD9, 1JWH, 4MD7, 4DGL

Interactors (88)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P68400 CSNK2A1	2	CSNK2A1 [cytosol] (R-HSA-201713) CSNK2A1 [nucleoplasm] (R-HSA-6805057)	0.978	33
UniProt:P19784 CSNK2A2	2	CSNK2A2 [cytosol] (R-HSA-201721) CSNK2A2 [nucleoplasm] (R-HSA-6805065)	0.948	18
UniProt:P67870 CSNK2B	5	CSNK2B [cytosol] (R-HSA-201693) CSNK2B [nucleoplasm] (R-HSA-6805067) CSNK2B [ficolin-1-rich granule lumen] (R-HSA-6801290) CSNK2B [extracellular region] (R-HSA-6806508) CSNK2B [secretory granule lumen] (R-HSA-6801319)	0.819	7
UniProt:P51812 RPS6KA3	7	p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm] (R-HSA-444286) p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619989) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619872) p-T365,S369,T577-RPS6KA3 [cytosol] (R-HSA-9619959) RPS6KA3 [cytosol] (R-HSA-444250) p-4S,T231,T365-RPS6KA3 [nucleoplasm] (R-HSA-199830) RPS6KA3 [nucleoplasm] (R-HSA-199869)	0.798	7
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.788	6
UniProt:Q99496 RNF2	1	RNF2 [nucleoplasm] (R-HSA-389119)	0.744	5
UniProt:Q15418 RPS6KA1	7	p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) RPS6KA1 [cytosol] (R-HSA-444256) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [nucleoplasm] (R-HSA-199860)	0.725	5
UniProt:Q8IY57 YAF2	1	YAF2 [nucleoplasm] (R-HSA-8937973)	0.725	6
UniProt:Q86SE9 PCGF5	1	PCGF5 [nucleoplasm] (R-HSA-8937962)	0.725	5
UniProt:Q8WXX7 AUTS2	1	AUTS2 [nucleoplasm] (R-HSA-8937967)	0.69	4
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.666	4
UniProt:O75582 RPS6KA5	3	p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm] (R-HSA-198683) RPS6KA5 [nucleoplasm] (R-HSA-198657) RPS6KA5 [cytosol] (R-HSA-772525)	0.659	3
UniProt:Q15349 RPS6KA2	7	p-S218,T356,S360,S377,T570,T730-RPS6KA2 [nucleoplasm] (R-HSA-444290) p-T356,S360,S377,T570,T730-RPS6KA2 [cytosol] (R-HSA-9619984) p-S218,T356,S360,S377,T570,T730-RPS6KA2 [cytosol] (R-HSA-9619869) p-T356,S360,T570-RPS6KA2 [cytosol] (R-HSA-9619955) RPS6KA2 [cytosol] (R-HSA-444252) p-4S,T356,T570-RPS6KA2 [nucleoplasm] (R-HSA-199871) RPS6KA2 [nucleoplasm] (R-HSA-199861)	0.659	4
UniProt:Q9WTL8 Arntl	7	p-S97-Bmal1 [nucleoplasm] (R-MMU-9920676) Arntl [cytosol] (R-MMU-508660) p-S97-Bmal1 [cytosol] (R-MMU-9912402) p-S-Arntl [nucleoplasm] (R-MMU-508690) Bmal1 [nucleoplasm] (R-MMU-9634872) Arntl [nucleoplasm] (R-MMU-9769624) p-S97,Ac-544-Bmal1 [nucleoplasm] (R-MMU-9920664)	0.646	4
UniProt:Q9UQ88 CDK11A	1	CDK11A [cytosol] (R-HSA-380457)	0.643	3
UniProt:P25440 BRD2	1	BRD2 [nucleoplasm] (R-HSA-8951979)	0.643	3
UniProt:Q8N5F7 NKAP	1	NKAP [nucleoplasm] (R-HSA-9769602)	0.643	5
UniProt:Q14781 CBX2	1	CBX2 [nucleoplasm] (R-HSA-389110)	0.643	3
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.643	3
UniProt:Q06587 RING1	1	RING1 [nucleoplasm] (R-HSA-389113)	0.643	4
UniProt:Q3KNV8 PCGF3			0.643	4
UniProt:Q96MH2 HEXI2			0.643	4
UniProt:Q9BW71 HIRP3			0.643	4
UniProt:P61962 DCAF7	2	DCAF7 [nucleoplasm] (R-HSA-8863312) Unfolded DCAF7 [cytosol] (R-HSA-6813821)	0.643	4
UniProt:Q96EB6 SIRT1	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.626	5
UniProt:Q6VY07 PACS1	1	PACS1 [cytosol] (R-HSA-167634)	0.593	3
UniProt:P97784 Cry1	5	Cry1 [cytosol] (R-MMU-508637) p-Cry1 [cytosol] (R-MMU-508644) p-Cry1 [nucleoplasm] (R-MMU-508662) K48polyUb-K107,p-S-Cry1 [cytosol] (R-MMU-9933323) K48polyUb-K,p-S-Cry1 [nucleoplasm] (R-MMU-517961)	0.592	2
UniProt:Q9UBS0 RPS6KB2	2	p-S15,S356-RPS6KB2 [nucleoplasm] (R-HSA-199844) RPS6KB2 [nucleoplasm] (R-HSA-199877)	0.589	3
UniProt:Q7Z6R9 TFAP2D	1	TFAP2D [nucleoplasm] (R-HSA-5626817)	0.556	3
UniProt:Q8IVT4 Q8IVT4			0.556	3
UniProt:P17023 ZNF19	1	ZNF19 [nucleoplasm] (R-HSA-974992)	0.556	3
UniProt:Q9BSJ6 PIMRE			0.556	3
UniProt:P01037 CYTN			0.556	3
UniProt:Q9NZH5-2 Q9NZH52			0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:Q9BZE0 GLIS2			0.556	3
UniProt:Q16656-4 NRF1			0.556	3
UniProt:Q8WU57 Q8WU57			0.556	3
UniProt:Q9C086 INO80B	1	INO80B [nucleoplasm] (R-HSA-5689599)	0.556	3
UniProt:Q9NZC7-5 WWOX			0.556	3
UniProt:hCG_2003792 A0A024R5S0			0.556	3
UniProt:Q12792 TWF1	1	TWF1 [cytosol] (R-HSA-9667687)	0.556	3
UniProt:Q8NEJ9 NGDN			0.556	3
UniProt:Q9NVL1-2 FAM86C1P			0.556	3
UniProt:Q9BYV2 TRI54			0.556	3
UniProt:Q8N9N5-2 BANP			0.556	3
UniProt:P09067 HXB5			0.556	3
UniProt:O43711 TLX3			0.556	3
UniProt:Q86VK4-3 ZNF410			0.556	3
UniProt:P46777 RPL5	1	RPL5 [cytosol] (R-HSA-72482)	0.553	2
UniProt:Q9BYB0 SHANK3	1	SHANK3 [cytosol] (R-HSA-6794277)	0.547	2
UniProt:O60551 NMT2	1	NMT2 [cytosol] (R-HSA-184377)	0.547	2
UniProt:P07199 CENPB			0.547	2
UniProt:Q9P1Y6 PHRF1			0.547	3
UniProt:P11274 BCR	4	BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838979) p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839041) BCR(1-584)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604524) BCR [cytosol] (R-HSA-195200)	0.527	3
UniProt:Q01831 XPC	5	XPC [nucleoplasm] (R-HSA-67441) Ub-XPC [nucleoplasm] (R-HSA-6782944) Ub,SUMO-XPC [nucleoplasm] (R-HSA-6790460) Ub,SUMO,K63polyUb-XPC [nucleoplasm] (R-HSA-6790522) monoSUMO1-K655-XPC [nucleoplasm] (R-HSA-4570458)	0.527	2
UniProt:Q6PD62 CTR9	1	CTR9 [nucleoplasm] (R-HSA-8866694)	0.527	3
UniProt:Q9UK58 CCNL1			0.527	2
UniProt:Q8WUQ7 CACTIN	1	CACTIN [nucleoplasm] (R-HSA-9769591)	0.527	3
UniProt:Q9NZR4 VSX1			0.527	2
UniProt:O75822 EIF3J	1	EIF3J [cytosol] (R-HSA-72534)	0.527	3
UniProt:Q9NW75 GPTC2			0.527	2
UniProt:Q8TDD1 DDX54			0.527	3
UniProt:Q9H5J8 TAF1D	1	TAF1D [nucleoplasm] (R-HSA-5138533)	0.527	2
UniProt:Q9HC52 CBX8	1	CBX8 [nucleoplasm] (R-HSA-389117)	0.527	2
UniProt:Q9BUG6 ZSA5A			0.527	2
UniProt:Q9ULW3 ABT1			0.527	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.527	2
UniProt:O75676 RPS6KA4	1	RPS6KA4 [cytosol] (R-HSA-772527)	0.527	3
UniProt:Q9NWQ4 GPT2L			0.527	2
UniProt:Q86US8 SMG6	1	SMG6 [cytosol] (R-HSA-927851)	0.527	2
UniProt:Q03164 KMT2A	6	KMT2A [nucleoplasm] (R-HSA-1183223) KMT2A(2719-3969) [nucleoplasm] (R-HSA-9818593) KMT2A(1-2718) [nucleoplasm] (R-HSA-9818591) KMT2A(1-2718) [cytosol] (R-HSA-9818597) KMT2A(2719-3969) [cytosol] (R-HSA-9818590) KMT2A [cytosol] (R-HSA-9818584)	0.527	3
UniProt:Q6ZUT1 NKAP1			0.527	3
UniProt:Q96B23 ARK2N			0.527	3
UniProt:Q92794 KAT6A	3	KAT6A [nucleoplasm] (R-HSA-480310) p-T369-KAT6A [nucleoplasm] (R-HSA-6805633) KAT6A (1-1118) [nucleoplasm] (R-HSA-5603260)	0.527	2
UniProt:Q00536 CDK16			0.527	2
UniProt:Q9HAH7 FBRS			0.527	3
UniProt:Q96IZ7 RSRC1			0.527	2
UniProt:P21127 CDK11B	1	CDK11B [cytosol] (R-HSA-380451)	0.527	2
UniProt:Q6ZNA4 RNF111	2	RNF111 [nucleoplasm] (R-HSA-2186765) RNF111 [cytosol] (R-HSA-975981)	0.527	3
UniProt:Q8N1G0 ZN687			0.527	3
UniProt:P19388 POLR2E	2	POLR2E [cytosol] (R-HSA-1964438) POLR2E [nucleoplasm] (R-HSA-83713)	0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q13363 CTBP1	3	CTBP1 [nucleoplasm] (R-HSA-212372) polySUMO2,3-K428-CTBP1 [nucleoplasm] (R-HSA-3108226) monoSUMO1-K428-CTBP1 [nucleoplasm] (R-HSA-3108200)	0.527	2
UniProt:O00555 CACNA1A	1	CACNA1A [plasma membrane] (R-HSA-210490)	0.508	2
UniProt:O08785 Clock	6	p-T451,T461-Clock [nucleoplasm] (R-MMU-9920668) Clock [cytosol] (R-MMU-508720) p-T451,T461-Clock [cytosol] (R-MMU-9920658) p-S-Clock [nucleoplasm] (R-MMU-508670) p-T451,T461,S440,S441,S446-Clock [nucleoplasm] (R-MMU-9920662) p-S,T451,T461,S440,S441,S446-Clock [nucleoplasm] (R-MMU-9927976)	0.508	2
UniProt:O00257-3 CBX4			0.499	2
UniProt:O60282 KIF5C	1	KIF5C [cytosol] (R-HSA-3878117)	0.463	2

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