Stimuli-sensing channels

Stable Identifier
Homo sapiens
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Ion channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et al. 2012, Deval et al. 2010) and the transient receptor potential channels (TRPCs) (Takahashi et al. 2012, Numata et al. 2011 in "TRP Channels" Zhu, MX editor, CRC Press, 2011, Ramsey et al. 2006, Montell 2005). Many channels are sensitive to changes in calcium (Ca2+) levels, both inside and outside the cell. Examples are protein tweety homologs 2 and 3 (TTYH2, 3) (Suzuki 2006), bestrophins 1-4 (BEST1-4) (Sun et al. 2002, Tsunenari et al. 2003, Kunzelmann et al. 2009, Hartzell et al. 2008) and ryanodine receptor tetramers (RYRs) (Beard et al. 2009).
Literature References
PubMed ID Title Journal Year
20807551 Acid-sensing ion channels (ASICs): pharmacology and implication in pain

Diochot, S, Salinas, M, Gasull, X, Noël, J, Deval, E, Baron, A, Lingueglia, E

Pharmacol. Ther. 2010
16219661 The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels

Suzuki, M

Exp. Physiol. 2006
21932071 Acidosis, acid-sensing ion channels, and neuronal cell death

Xu, TL, Wang, YZ

Mol. Neurobiol. 2011
12907679 Structure-function analysis of the bestrophin family of anion channels

Yau, KW, Williams, J, Sun, H, Smallwood, P, Nathans, J, Tsunenari, T, Cahill, H

J. Biol. Chem. 2003
18391176 Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies

Xiao, Q, Hartzell, HC, Qu, Z, Chien, LT, Yu, K

Physiol. Rev. 2008
  TRP Channels

Xhu, MX

11904445 The vitelliform macular dystrophy protein defines a new family of chloride channels

Yau, KW, Sun, H, Nathans, J, Tsunenari, T

Proc. Natl. Acad. Sci. U.S.A. 2002
15728426 The TRP superfamily of cation channels

Montell, C

Sci. STKE 2005
16460286 An introduction to TRP channels

Clapham, DE, Ramsey, IS, Delling, M

Annu. Rev. Physiol. 2006
19783045 Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions

Ousingsawat, J, Warth, R, Aldehni, F, Kongsuphol, P, Kunzelmann, K, Schreiber, R, Tian, Y

Cell Calcium 2009
19278523 Control of muscle ryanodine receptor calcium release channels by proteins in the sarcoplasmic reticulum lumen

Dulhunty, AF, Wei, L, Beard, NA

Clin. Exp. Pharmacol. Physiol. 2009
22277752 ENaCs and ASICs as therapeutic targets

Rooj, AK, Qadri, YJ, Fuller, CM

Am. J. Physiol., Cell Physiol. 2012
22934072 TRP channels: sensors and transducers of gasotransmitter signals

Takahashi, N, Mori, Y, Kozai, D

Front Physiol 2012
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