Reactome | Stimuli-sensing channels

Stimuli-sensing channels

Stable Identifier

R-HSA-2672351

DOI

10.3180/REACT_160189.1

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Ion channels that mediate sensations such as pain, warmth, cold, taste pressure and vision. Channels that mediate these sensations include acid-sensing ion channels (ASICs) (Wang & Xu 2011, Qadri et al. 2012, Deval et al. 2010) and the transient receptor potential channels (TRPCs) (Takahashi et al. 2012, Numata et al. 2011 in "TRP Channels" Zhu, MX editor, CRC Press, 2011, Ramsey et al. 2006, Montell 2005). Many channels are sensitive to changes in calcium (Ca2+) levels, both inside and outside the cell. Examples are protein tweety homologs 2 and 3 (TTYH2, 3) (Suzuki 2006), bestrophins 1-4 (BEST1-4) (Sun et al. 2002, Tsunenari et al. 2003, Kunzelmann et al. 2009, Hartzell et al. 2008) and ryanodine receptor tetramers (RYRs) (Beard et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
20807551	Acid-sensing ion channels (ASICs): pharmacology and implication in pain Deval, E, Gasull, X, Noël, J, Salinas, M, Baron, A, Diochot, S, Lingueglia, E	Pharmacol. Ther.	2010
16219661	The Drosophila tweety family: molecular candidates for large-conductance Ca2+-activated Cl- channels Suzuki, M	Exp. Physiol.	2006
21932071	Acidosis, acid-sensing ion channels, and neuronal cell death Wang, YZ, Xu, TL	Mol. Neurobiol.	2011
12907679	Structure-function analysis of the bestrophin family of anion channels Tsunenari, T, Sun, H, Williams, J, Cahill, H, Smallwood, P, Yau, KW, Nathans, J	J. Biol. Chem.	2003
18391176	Molecular physiology of bestrophins: multifunctional membrane proteins linked to best disease and other retinopathies Hartzell, HC, Qu, Z, Yu, K, Xiao, Q, Chien, LT	Physiol. Rev.	2008
	TRP Channels Xhu, MX		2011
11904445	The vitelliform macular dystrophy protein defines a new family of chloride channels Sun, H, Tsunenari, T, Yau, KW, Nathans, J	Proc. Natl. Acad. Sci. U.S.A.	2002
15728426	The TRP superfamily of cation channels Montell, C	Sci. STKE	2005
16460286	An introduction to TRP channels Ramsey, IS, Delling, M, Clapham, DE	Annu. Rev. Physiol.	2006
19783045	Bestrophin and TMEM16-Ca(2+) activated Cl(-) channels with different functions Kunzelmann, K, Kongsuphol, P, Aldehni, F, Tian, Y, Ousingsawat, J, Warth, R, Schreiber, R	Cell Calcium	2009
19278523	Control of muscle ryanodine receptor calcium release channels by proteins in the sarcoplasmic reticulum lumen Beard, NA, Wei, L, Dulhunty, AF	Clin. Exp. Pharmacol. Physiol.	2009
22277752	ENaCs and ASICs as therapeutic targets Qadri, YJ, Rooj, AK, Fuller, CM	Am. J. Physiol., Cell Physiol.	2012
22934072	TRP channels: sensors and transducers of gasotransmitter signals Takahashi, N, Kozai, D, Mori, Y	Front Physiol	2012