Reactome | CAP1 [cytosol]

CAP1 [cytosol]

Stable Identifier

R-HSA-350758

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Adenylyl cyclase-associated protein 1

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Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Signaling by ROBO receptors (Homo sapiens)
      - Role of ABL in ROBO-SLIT signaling (Homo sapiens)
        
        Recruitment of CAP to ABL (Homo sapiens)
        
        CAP [cytosol] (Homo sapiens)
        
        CAP1 [cytosol] (Homo sapiens)
        
        SLIT2:ROBO1:ABL:CAP [plasma membrane] (Homo sapiens)
        
        CAP [cytosol] (Homo sapiens)
        
        CAP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q01518 CAP1

Gene Names

CAP1, CAP

Chain

initiator methionine:, chain:2-475

Reference Genes

BioGPS Gene:10487 CAP1

COSMIC (genes):CAP1 CAP1

CTD Gene:10487 CAP1

dbSNP Gene:10487 CAP1

ENSEMBL:ENSG00000131236 CAP1

ENSEMBL_homo_sapiens_GENE:ENSG00000131236.18 CAP1

HGNC:20040 CAP1

KEGG Gene (Homo sapiens):10487 CAP1

Monarch:10487 CAP1

NCBI Gene:10487 CAP1

OMIM:617801 CAP1

UCSC:Q01518 CAP1

Reference Transcript

Other Identifiers

10487

11719377_x_at

11745801_s_at

16662968

200625_PM_s_at

200625_s_at

213798_PM_s_at

213798_s_at

2331728

2331729

2331737

2331738

2331739

2331740

2331741

2331743

2331744

2331745

2331746

2331750

2331752

2331753

2331755

2331757

2331758

2331760

2630486

2630488

2630494

3286367

3286369

7900382

935_at

A_14_P104430

A_24_P62615

A_33_P3281816

GE61261

GO:0000902

GO:0001667

GO:0003779

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005764

GO:0005773

GO:0005856

GO:0005886

GO:0005925

GO:0006898

GO:0007010

GO:0007015

GO:0007163

GO:0007165

GO:0007190

GO:0008092

GO:0008179

GO:0016020

GO:0016192

GO:0019933

GO:0023052

GO:0030036

GO:0030864

GO:0031410

GO:0035578

GO:0043226

GO:0048856

GO:0048870

GO:0070062

HMNXSV003021654

Hs.104125.2.A1_3p_a_at

ILMN_1797604

ILMN_1880116

L12168_at

PH_hs_0005778

TC01000504.hg

g10938021_3p_a_at

Participates

as a member of

Other forms of this molecule

CAP1 [extracellular region]

CAP1 [azurophil granule lumen]

Cross References

RefSeq

XP_016855561.1, XP_016855559.1, XP_011538815.1, XP_005270425.1, NP_001099000.1, XP_016855557.1, XP_011538813.1, XP_016855560.1, XP_016855558.1, XP_011538814.1, XP_011538812.1, XP_011538817.1, XP_016855556.1, XP_011538816.1, NP_006358.1, XP_011538811.1

OpenTargets

ENSG00000131236

HPA

ENSG00000131236-CAP1

GeneCards

Q01518

Ensembl

ENST00000372805, ENST00000372802, ENSP00000361891, ENST00000340450, ENSP00000361883, ENSP00000361884, ENST00000372792, ENSP00000361878, ENSP00000361888, ENSP00000344832, ENST00000372798, ENSG00000131236, ENST00000372797

PRO

Q01518

Pharos - Targets

Q01518

PDB

1K8F

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.725	14
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.613	3
UniProt:P60709 ACTB	5	Unfolded ACTB [cytosol] (R-HSA-390462) ACTB(1-375) [nucleoplasm] (R-HSA-3321990) ACTB(1-375) [cytosol] (R-HSA-201861) ACTB(1-375) [lysosomal membrane] (R-HSA-196160) ACTB(1-375) [plasma membrane] (R-HSA-196016)	0.527	4

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