Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
TPM3 [cytosol]
Stable Identifier
R-HSA-390543
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tropomyosin alpha-3 chain, TPM3_HUMAN
Locations in the PathwayBrowser
Expand all
Muscle contraction (Homo sapiens)
Smooth Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
Calcium Binds Caldesmon (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
Striated Muscle Contraction (Homo sapiens)
ATP Hydrolysis By Myosin (Homo sapiens)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
Calcium Binds Troponin-C (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
Inactive Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
Myosin Binds ATP (Homo sapiens)
ATP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
Release Of ADP From Myosin (Homo sapiens)
ADP:Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
Calcium Bound Sarcomere Protein Complex [cytosol] (Homo sapiens)
Thin Filament With Troponin Bound Calcium [cytosol] (Homo sapiens)
Tropomyosin [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RHOV GTPase cycle (Homo sapiens)
RHOV binds effectors at the plasma membrane (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
RHOV:GTP:RHOV effectors [plasma membrane] (Homo sapiens)
RHOV effectors [cytosol] (Homo sapiens)
TPM3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P06753 TPM3
Gene Names
TPM3
Chain
initiator methionine:1, initiator methionine:, initiator methionine:, chain:2-285
Reference Genes
BioGPS Gene:7170 TPM3
COSMIC (genes):TPM3 TPM3
CTD Gene:7170 TPM3
dbSNP Gene:7170 TPM3
ENSEMBL:ENSG00000143549 TPM3
ENSEMBL:ENSG00000143549.22 TPM3
HGNC:12012 TPM3
KEGG Gene (Homo sapiens):7170 TPM3
Monarch:7170 TPM3
NCBI Gene:7170 TPM3
OMIM:191030 TPM3
UCSC:P06753 TPM3
Reference Transcript
RefSeq:NM_001043351.1 TPM3
RefSeq:NM_153649.3 TPM3
RefSeq:NM_152263.3 TPM3
RefSeq:NM_001278191.1 TPM3
RefSeq:NM_001278189.1 TPM3
RefSeq:NM_001043353.1 TPM3
RefSeq:NM_001043352.1 TPM3
Other Identifiers
11715666_a_at
11715667_s_at
11721289_at
11731455_at
11746919_a_at
11749935_s_at
11750045_x_at
214365_PM_at
214365_at
222976_3p_s_at
222976_PM_s_at
222976_s_at
224164_PM_at
224164_at
238065_PM_at
238065_at
238079_PM_at
238079_at
2436522
2436523
2436525
2436527
2436528
2436529
2436530
2436531
2436532
2436533
2436534
2436535
2436536
2436537
2436538
2436539
2436540
2436541
2436543
2436546
2436548
2436550
2436552
2436553
2436554
2436557
2436558
2436564
2436565
2436566
2436569
2436570
2436571
2436574
2436575
3069273
32754_at
3588684
3660774
3815587
3834246
3834250
43197_at
55837_at
57840_at
7170
73377_at
75021_at
7920472
8142468
89615_at
A_23_P346086
A_24_P393880
A_32_P119197
A_33_P3223980
A_33_P3223990
A_33_P3346193
GE84825
GE85555
GO:0001725
GO:0003012
GO:0003674
GO:0003779
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005829
GO:0005856
GO:0005862
GO:0005884
GO:0006936
GO:0007010
GO:0007015
GO:0008092
GO:0015629
GO:0043226
GO:0051015
GO:0070062
HMNXSV003000428
HMNXSV003018117
HMNXSV003038944
Hs.146070.0.A1_3p_at
Hs.169514.0.A1_3p_at
Hs.85844.3.S1_3p_at
ILMN_1660775
ILMN_1686388
ILMN_1697567
ILMN_1747696
PH_hs_0029336
PH_hs_0040951
X04201_at
g12653954_3p_a_at
g12653954_3p_s_at
g12653954_3p_x_at
g9508584_3p_at
Participates
as a candidate of
RHOV effectors [cytosol] (Homo sapiens)
as a member of
Tropomyosin [cytosol] (Homo sapiens)
Other forms of this molecule
TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol]
TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol]
Inferred To
TPM1 [cytosol]
(Saccharomyces cerevisiae)
Tpm3 [cytosol]
(Mus musculus)
Tm1 [cytosol]
(Drosophila melanogaster)
cdc8 [cytosol]
(Schizosaccharomyces pombe)
TPM3 [cytosol]
(Bos taurus)
TPM3 [cytosol]
(Canis familiaris)
TPM3 [cytosol]
(Danio rerio)
TPM3 [cytosol]
(Gallus gallus)
TPM3 [cytosol]
(Sus scrofa)
lev-11 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001265118.1
,
NP_001036816.1
,
NP_689476.2
,
NP_001036818.1
,
NP_705935.1
,
NP_001265120.1
,
NP_001036817.1
OpenTargets
ENSG00000143549
GeneCards
P06753
HPA
ENSG00000143549-TPM3
Ensembl
ENSP00000498577
,
ENSP00000339035
,
ENSG00000143549
,
ENST00000330188
,
ENSP00000341653
,
ENST00000302206
,
ENSP00000357518
,
ENSP00000357517
,
ENSP00000357520
,
ENST00000328159
,
ENST00000323144
,
ENSP00000357521
,
ENSP00000307712
,
ENST00000651641
,
ENST00000368531
,
ENST00000368533
,
ENST00000341485
PRO
P06753
Pharos - Targets
P06753
Orphanet
15649
HMDB Protein
HMDBP08072
PDB
6OTN
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y6D9 MAD1L1
1
MAD1L1 [cytosol]
(R-HSA-141433)
0.849
10
UniProt:Q8N0S2 SYCE1
1
SYCE1 [nucleoplasm]
(R-HSA-912456)
0.735
7
UniProt:O14879 IFIT3
1
IFIT3 [cytosol]
(R-HSA-947491)
0.696
5
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
14
UniProt:Q14164 IKBKE
4
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
0.589
2
UniProt:P21796 VDAC1
4
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
0.564
4
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text