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PolyUb-VDAC1 [mitochondrial outer membrane]
Stable Identifier
R-HSA-6783079
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
VDAC1, Voltage-dependent anion-selective channel protein 1, VDAC1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP30 deubiquitinates Ub-MOM proteins (Homo sapiens)
USP30:PolyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
PolyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
PolyUb-VDAC1 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P21796 VDAC1
Gene Names
VDAC1, VDAC
Chain
initiator methionine:1, chain:2-283
Reference Genes
BioGPS Gene:7416 VDAC1
COSMIC (genes):VDAC1 VDAC1
CTD Gene:7416 VDAC1
dbSNP Gene:7416 VDAC1
ENSEMBL:ENSG00000213585 VDAC1
ENSEMBL:ENSG00000213585.11 VDAC1
HGNC:12669 VDAC1
KEGG Gene (Homo sapiens):7416 VDAC1
Monarch:7416 VDAC1
NCBI Gene:7416 VDAC1
OMIM:604492 VDAC1
UCSC:P21796 VDAC1
Reference Transcript
RefSeq:NM_003374.2 VDAC1
RefSeq:XM_017009821.1 VDAC1
RefSeq:XM_005272075.3 VDAC1
RefSeq:XM_017009822.1 VDAC1
RefSeq:XM_017009823.1 VDAC1
Other Identifiers
11715655_s_at
16999985
212038_PM_s_at
212038_s_at
217140_PM_s_at
217140_s_at
2370085
2683588
2875955
2875956
2875957
2875958
2875959
2875960
2875961
2875962
2875963
2875964
2875965
2875966
2875967
2875968
2875980
31608_g_at
3456919
3982776
3982780
3982781
4008064
4008066
4008075
4008077
4014643
40198_at
4033601
7416
8114145
A_23_P144816
GE57563
GO:0001662
GO:0005215
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005739
GO:0005741
GO:0005757
GO:0005886
GO:0006090
GO:0006811
GO:0006820
GO:0006914
GO:0006915
GO:0007005
GO:0007268
GO:0007270
GO:0007612
GO:0008289
GO:0008308
GO:0012501
GO:0015288
GO:0015485
GO:0016020
GO:0019901
GO:0023052
GO:0030154
GO:0030855
GO:0031210
GO:0031966
GO:0042645
GO:0042802
GO:0043066
GO:0043226
GO:0044325
GO:0045121
GO:0045202
GO:0046930
GO:0048856
GO:0050877
GO:0055085
GO:0070062
GO:0097001
GO:0098656
GO:0110099
GO:1903146
GO:1905091
GO:2000378
HMNXSV003020379
Hs.149155.2.A1_3p_a_at
ILMN_2175601
L06132_at
PH_hs_0030040
TC05001785.hg
TC05003242.hg
p33706
Participates
as a candidate of
PolyUb-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
Other forms of this molecule
VDAC1 [mitochondrial intermembrane space]
VDAC1 [mitochondrial outer membrane]
K48polyUb-VDAC1 [mitochondrial outer membrane]
Inferred To
Porin2 [mitochondrial outer membrane]
(Drosophila melanogaster)
fa13f11 [mitochondrial outer membrane]
(Danio rerio)
vdac-1 [mitochondrial outer membrane]
(Caenorhabditis elegans)
POR1 [mitochondrial outer membrane]
(Saccharomyces cerevisiae)
CG31722 [mitochondrial outer membrane]
(Drosophila melanogaster)
CG31722-B [mitochondrial outer membrane]
(Drosophila melanogaster)
POR2 [mitochondrial outer membrane]
(Saccharomyces cerevisiae)
Homologues of PolyUb-VDAC1 [mitochondrial outer membrane]
(Drosophila melanogaster)
Homologues of PolyUb-VDAC1 [mitochondrial outer membrane]
(Saccharomyces cerevisiae)
porin [mitochondrial outer membrane]
(Drosophila melanogaster)
PolyUb-VDAC1 [mitochondrial outer membrane]
(Bos taurus)
PolyUb-VDAC1 [mitochondrial outer membrane]
(Canis familiaris)
PolyUb-VDAC1 [mitochondrial outer membrane]
(Gallus gallus)
PolyUb-VDAC1 [mitochondrial outer membrane]
(Mus musculus)
PolyUb-VDAC1 [mitochondrial outer membrane]
(Rattus norvegicus)
PolyUb-VDAC1 [mitochondrial outer membrane]
(Sus scrofa)
Modified Residues
Name
ubiquitinylated lysine (PolyUb [mitochondrial outer membrane]) at unknown position
Modification
PolyUb [mitochondrial outer membrane]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_016865310.1
,
XP_016865312.1
,
XP_005272132.1
,
XP_016865311.1
,
NP_003365.1
OpenTargets
ENSG00000213585
GeneCards
P21796
HPA
ENSG00000213585-VDAC1
Ensembl
ENSG00000213585
,
ENSP00000378487
,
ENSP00000378484
,
ENSP00000265333
,
ENST00000265333
,
ENST00000395047
,
ENST00000395044
PRO
P21796
Pharos - Targets
P21796
Orphanet
26468
HMDB Protein
HMDBP02507
PDB
2JK4
,
5XDO
,
7QI2
,
6TIR
,
5XDN
,
5JDP
,
2K4T
,
6G6U
,
6TIQ
,
6G73
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P21796 VDAC1
4
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
0.655
4
UniProt:P0C0U1 PB1
2
PB1-F2 [mitochondrial intermembrane space]
(R-FLU-5146789)
PB1-F2 [cytosol]
(R-FLU-169216)
0.591
4
UniProt:P15336 ATF2
2
ATF2 [nucleoplasm]
(R-HSA-450336)
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
0.576
3
UniProt:P12236 SLC25A6
2
SLC25A6 [mitochondrial intermembrane space]
(R-HSA-1955374)
SLC25A6 [mitochondrial inner membrane]
(R-HSA-49745)
0.564
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.564
3
UniProt:P81605 DCD
4
DCD(20-62) [extracellular region]
(R-HSA-6802986)
DCD(20-110) [extracellular region]
(R-HSA-6802997)
DCD(63-110) [extracellular region]
(R-HSA-6802991)
DCD(63-109) [extracellular region]
(R-HSA-6801811)
0.564
2
UniProt:Q9Y277 VDAC3
2
PolyUb-VDAC3 [mitochondrial outer membrane]
(R-HSA-6783045)
VDAC3 [mitochondrial outer membrane]
(R-HSA-5696901)
0.564
2
UniProt:P06753 TPM3
3
TPM3 [cytosol]
(R-HSA-390543)
TPM3(2-258)insV-p-7Y-ALK(1059-1620) fusion [cytosol]
(R-HSA-9710837)
TPM3(2-258)insV-ALK(1059-1620) fusion [cytosol]
(R-HSA-9710848)
0.564
4
UniProt:Q07813
2
Bax [cytosol]
(R-MMU-139907)
Bax [mitochondrial outer membrane]
(R-MMU-139949)
0.544
2
UniProt:Q7L3V2 BOP
0.544
2
UniProt:Q16611 BAK1
2
BAK1 [mitochondrial outer membrane]
(R-HSA-139896)
BAK1 activated [mitochondrial outer membrane]
(R-HSA-50690)
0.544
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P27824 CANX
2
CANX [integral component of lumenal side of endoplasmic reticulum membrane]
(R-HSA-983091)
CANX [endoplasmic reticulum lumen]
(R-HSA-195906)
0.527
3
UniProt:P0DTD1-PRO_0000449624 REP
0.527
2
UniProt:P27105 STOM
4
STOM [specific granule membrane]
(R-HSA-6799569)
STOM [plasma membrane]
(R-HSA-6806258)
STOM [azurophil granule membrane]
(R-HSA-6800997)
STOM [tertiary granule membrane]
(R-HSA-6800960)
0.508
2
UniProt:P06493 CDK1
11
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
CDK1 [nucleoplasm]
(R-HSA-68889)
CDK1 [cytosol]
(R-HSA-170075)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
0.499
3
UniProt:P30041 PRDX6
3
PRDX6 [extracellular region]
(R-HSA-6806198)
PRDX6 [azurophil granule lumen]
(R-HSA-6798744)
PRDX6 [cytosol]
(R-HSA-3343670)
0.499
3
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.499
5
UniProt:P45880 VDAC2
2
PolyUb-VDAC2 [mitochondrial outer membrane]
(R-HSA-6783185)
VDAC2 [mitochondrial outer membrane]
(R-HSA-5696880)
0.499
5
UniProt:Q9H9B4 SFXN1
0.483
4
UniProt:P04578-PRO_0000038428 ENV
0.462
2
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