Reactome | p-T509,T514,S518,S522-CRMP1 [cytosol]

p-T509,T514,S518,S522-CRMP1 [cytosol]

Stable Identifier

R-HSA-399777

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S518,S522,T509,T514-CRMP1, pCRMP-1 (S522,S518,T509,T514)

Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - CRMPs in Sema3A signaling (Homo sapiens)
        
        Phosphorylation of CRMPs by GSK3beta (Homo sapiens)
        
        Sema3A:Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's [plasma membrane] (Homo sapiens)
        
        Nrp-1:PlexinA:Fyn:Cdk5:pCRMP's (S522,S518,T509,T514) [plasma membrane] (Homo sapiens)
        
        PlexinA1-4:FYN:CDK5:p-CRMPs (S522,S518,T509,T514) [plasma membrane] (Homo sapiens)
        
        pCRMP's tetramers (S522,S518,T509,T514) [cytosol] (Homo sapiens)
        
        GSK3beta phosphorylated CRMP's 1-5 [cytosol] (Homo sapiens)
        
        p-T509,T514,S518,S522-CRMP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14194 CRMP1

Gene Names

CRMP1, DPYSL1, ULIP3

Chain

chain:1-572

Reference Genes

BioGPS Gene:1400 CRMP1

COSMIC (genes):CRMP1 CRMP1

CTD Gene:1400 CRMP1

dbSNP Gene:1400 CRMP1

ENSEMBL:ENSG00000072832 CRMP1

HGNC:2365 CRMP1

KEGG:hsa:1400 CRMP1

Monarch:1400 CRMP1

NCBI Gene:1400 CRMP1

OMIM:602462 CRMP1

UCSC:Q14194 CRMP1

Reference Transcript

Other Identifiers

11716501_a_at

11716502_x_at

11716503_a_at

11716504_x_at

1400

16973975

17118035

202517_PM_at

202517_at

2759039

2759045

2759046

2759047

2759050

2759051

2759052

2759058

2759059

2759061

2759062

2759063

2759064

2759065

2759066

2759068

2759070

2759072

2759073

2759079

2759083

2759084

2759085

2759086

2759087

2759088

2759089

2759091

2759092

2759093

2759095

2759096

40272_at

8099172

ADDON000778.hg

ADDON001396.hg

A_21_P0014133

A_23_P132889

A_24_P20506

D78012_at

GE57292

GE86402

GO:0003824

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0006139

GO:0007399

GO:0008092

GO:0010977

GO:0016787

GO:0016810

GO:0016812

GO:0030426

GO:0030496

GO:0031005

GO:0042802

GO:0042995

GO:0043204

GO:0043226

GO:0048856

HMNXSV003027267

HMNXSV003038360

ILMN_1664502

ILMN_1789541

ILMN_1811405

PH_hs_0009357

TC04000997.hg

g4503050_3p_at

Participates

as a member of

GSK3beta phosphorylated CRMP's 1-5 [cytosol] (Homo sapiens)

Other forms of this molecule

p-S522-CRMP1 [cytosol]

p-Y-CRMP1 [cytosol]

CRMP1 [cytosol]

Inferred To

Homologues of p-T509,T514,S518,S522-CRMP1 [cytosol] (Caenorhabditis elegans)

phospho-unc-33 [cytosol] (Caenorhabditis elegans)

phospho-p-T509,T514,S518,S522-CRMP1 [cytosol] (Caenorhabditis elegans)

phospho-CRMP1A [cytosol] (Gallus gallus)

phospho-CRMP [cytosol] (Drosophila melanogaster)

phospho-CRMP1 [cytosol] (Bos taurus)

phospho-CRMP1 [cytosol] (Canis familiaris)

phospho-CRMP1 [cytosol] (Sus scrofa)

phospho-Crmp1 [cytosol] (Mus musculus)

phospho-Crmp1 [cytosol] (Rattus norvegicus)

phospho-crmp1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 522

Coordinate

522

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 518

Coordinate

518

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 509

Coordinate

509

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 514

Coordinate

514

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

RefSeq

NP_001275590.1, NP_001304.1, NP_001014809.1, NP_001275591.1

ENSEMBL

ENST00000324989, ENSP00000380987, ENST00000397890, ENSP00000321606

OpenTargets

ENSG00000072832

HPA

ENSG00000072832-CRMP1

PRO

Q14194

Pharos - Targets

Q14194

GlyGen

Q14194

PDB

4B3Z

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.703	14
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.635	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912)	0.556	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.556	3
UniProt:P04183 TK1	1	TK1 [cytosol] (R-HSA-73500)	0.553	2
UniProt:O15169 AXIN1	11	AXIN1 [cytosol] (R-HSA-195249) p-T481,S486,S493-AXIN1 [cytosol] (R-HSA-206040) ub-AXIN1 [cytosol] (R-HSA-4641133) RibC-AXIN1 [cytosol] (R-HSA-3640841) Ub-RibC-AXIN1 [cytosol] (R-HSA-3640864) AXIN1 P255S [cytosol] (R-HSA-5251505) AXIN1 P354L [cytosol] (R-HSA-5251511) AXIN1 W247* [cytosol] (R-HSA-5251512) AXIN1 E406* [cytosol] (R-HSA-5251500) AXIN1 Y346* [cytosol] (R-HSA-4839753) AXIN1 L396M [cytosol] (R-HSA-5251503)	0.508	2