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AXIN1 [cytosol]
Stable Identifier
R-HSA-195249
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by WNT in cancer (Homo sapiens)
Signaling by AMER1 mutants (Homo sapiens)
Truncations of AMER1 destabilize the destruction complex (Homo sapiens)
Truncated AMER1 mutants destabilize the destruction complex (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
Signaling by APC mutants (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
Signaling by CTNNB1 phospho-site mutants (Homo sapiens)
CTNNB1 S33 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S33 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pS37,T41,S45-CTNNB1 S33 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
CTNNB1 S37 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S37 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pT41,S45-CTNNB1 S37 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
CTNNB1 S45 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 S45 mutants aren't phosphorylated by CK1alpha (Homo sapiens)
CTNNB1 S45 mutants:AXIN:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
CTNNB1 T41 mutants aren't phosphorylated (Homo sapiens)
CTNNB1 T41 mutants aren't phosphorylated by GSK3beta (Homo sapiens)
pS45-CTNNB1 T41 mutants:Axin:GSK3:CK1alpha:APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX1 (Homo sapiens)
RUNX1 regulates estrogen receptor mediated transcription (Homo sapiens)
AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
RUNX1 regulates transcription of genes involved in WNT signaling (Homo sapiens)
AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Degradation of beta-catenin by the destruction complex (Homo sapiens)
AXIN is phosphorylated in the destruction complex (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
Assembly of the destruction complex (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
Expression of AXIN1 gene (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of AXIN (Homo sapiens)
AXIN is ubiquitinated by SMURF2 (Homo sapiens)
AXIN:SMURF2 [cytosol] (Homo sapiens)
AXIN [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
SMURF2 binds AXIN (Homo sapiens)
AXIN [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
AXIN:SMURF2 [cytosol] (Homo sapiens)
AXIN [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
Tankyrase ADP-ribosylates AXIN (Homo sapiens)
AXIN:TNKS [cytosol] (Homo sapiens)
AXIN [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
Tankyrase binds AXIN (Homo sapiens)
AXIN [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
AXIN:TNKS [cytosol] (Homo sapiens)
AXIN [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
Disassembly of the destruction complex and recruitment of AXIN to the membrane (Homo sapiens)
Beta-catenin is released from the destruction complex (Homo sapiens)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
GSK3B:AXIN1 [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
GSK3B:AXIN1 [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
DVL recruits GSK3beta:AXIN1 to the receptor complex (Homo sapiens)
GSK3B:AXIN1 [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
GSK3B:AXIN1 [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex (Homo sapiens)
CTNNB1:AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI (Homo sapiens)
WNT:FZD:p10S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
GSK3B:AXIN1 [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
GSK3B:AXIN1 [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta (Homo sapiens)
WNT:FZD:LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
GSK3B:AXIN1 [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
WNT:FZD:p5S/T-LRP5/6:DVL:AXIN:GSK3B [plasma membrane] (Homo sapiens)
GSK3B:AXIN1 [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
WNT3A stimulates the caveolin-dependent internalization of FZD5:p-LRP6 (Homo sapiens)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [early endosome membrane] (Homo sapiens)
GSK3B:AXIN1 [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
WNT3A:FZD5:p-LRP6:GSK3B:AXIN:CAV1 [plasma membrane] (Homo sapiens)
GSK3B:AXIN1 [cytosol] (Homo sapiens)
AXIN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O15169 AXIN1
Gene Names
AXIN1, AXIN
Chain
chain:1-862
Reference Genes
BioGPS Gene:8312 AXIN1
COSMIC (genes):AXIN1 AXIN1
CTD Gene:8312 AXIN1
dbSNP Gene:8312 AXIN1
ENSEMBL:ENSG00000103126 AXIN1
ENSEMBL_homo_sapiens_GENE:ENSG00000103126.15 AXIN1
HGNC:903 AXIN1
KEGG Gene (Homo sapiens):8312 AXIN1
Monarch:8312 AXIN1
NCBI Gene:8312 AXIN1
OMIM:603816 AXIN1
UCSC:O15169 AXIN1
Reference Transcript
RefSeq:NM_003502.3 AXIN1
RefSeq:NM_181050.2 AXIN1
Other Identifiers
11754511_a_at
16822408
212849_PM_at
212849_at
33319_at
3675048
3675049
3675051
3675053
3675055
3675056
3675057
3675058
3675059
3675062
3675066
3675069
3675070
3675090
3675091
3675092
7998211
8312
AF009674_at
GE61790
GO:0000209
GO:0001701
GO:0001932
GO:0001934
GO:0002039
GO:0005515
GO:0005634
GO:0005730
GO:0005737
GO:0005829
GO:0005856
GO:0005886
GO:0005938
GO:0006351
GO:0006355
GO:0006913
GO:0006915
GO:0007010
GO:0007605
GO:0008013
GO:0009950
GO:0009953
GO:0010629
GO:0010800
GO:0012501
GO:0015630
GO:0016020
GO:0016055
GO:0016328
GO:0019899
GO:0019901
GO:0019904
GO:0023052
GO:0030154
GO:0030163
GO:0030178
GO:0030511
GO:0030877
GO:0031122
GO:0031398
GO:0031410
GO:0031625
GO:0032147
GO:0032436
GO:0032991
GO:0033138
GO:0034244
GO:0035591
GO:0036211
GO:0036342
GO:0042802
GO:0042803
GO:0043161
GO:0043226
GO:0043621
GO:0044725
GO:0045599
GO:0045732
GO:0046330
GO:0046332
GO:0048318
GO:0048320
GO:0048468
GO:0048471
GO:0048856
GO:0050877
GO:0051248
GO:0060070
GO:0060090
GO:0060322
GO:0060828
GO:0065003
GO:0070016
GO:0070411
GO:0070412
GO:0071944
GO:0090090
GO:1990756
GO:1990909
GO:2000060
HMNXSV003035039
HMNXSV003043314
Hs.184434.0.S1_3p_at
ILMN_1692967
ILMN_1766185
PH_hs_0026858
TC16000725.hg
Participates
as an input of
Truncated AMER1 mutants destabilize the destruction complex (Homo sapiens)
APC truncation mutants have impaired AXIN binding (Homo sapiens)
Assembly of the destruction complex (Homo sapiens)
as an output of
AXIN1 gene expression is inhibited by ESR1 and stimulated by RUNX1 (Homo sapiens)
Expression of AXIN1 gene (Homo sapiens)
as a member of
AXIN [cytosol] (Homo sapiens)
as a component of
GSK3B:AXIN1 [cytosol] (Homo sapiens)
AXIN:GSK3:CK1alpha:ub-APC:PP2A:AMER1 complex [cytosol] (Homo sapiens)
Other forms of this molecule
AXIN1 L396M [cytosol]
AXIN1 Y346* [cytosol]
AXIN1 E406* [cytosol]
AXIN1 W247* [cytosol]
AXIN1 P354L [cytosol]
AXIN1 P255S [cytosol]
ub-AXIN1 [cytosol]
Ub-RibC-AXIN1 [cytosol]
RibC-AXIN1 [cytosol]
p-T481,S486,S493-AXIN1 [cytosol]
Inferred To
axin1 [cytosol]
(Danio rerio)
pry-1 [cytosol]
(Caenorhabditis elegans)
Axn [cytosol]
(Drosophila melanogaster)
AXIN1 [cytosol]
(Bos taurus)
AXIN1 [cytosol]
(Canis familiaris)
AXIN1 [cytosol]
(Gallus gallus)
AXIN1 [cytosol]
(Sus scrofa)
Axin1 [cytosol]
(Mus musculus)
Axin1 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_003493.1
,
NP_851393.1
OpenTargets
ENSG00000103126
HPA
ENSG00000103126-AXIN1
GeneCards
O15169
Ensembl
ENSP00000346935
,
ENST00000354866
,
ENSG00000103126
,
ENST00000262320
,
ENSP00000262320
PRO
O15169
Pharos - Targets
O15169
Orphanet
24358
HMDB Protein
HMDBP14519
PDB
3ZDI
,
4B7T
,
4NM3
,
7SXJ
,
7SXF
,
4NU1
,
4NM5
,
4NM7
,
7SXG
,
1O9U
,
1EMU
,
1DK8
,
5WZZ
,
4NM0
,
7SXH
,
7Y1P
,
6JCK
Interactors (65)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.976
52
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.94
44
UniProt:P25054 APC
20
APC R213* [cytosol]
(R-HSA-9666924)
APC C1410* [cytosol]
(R-HSA-9666925)
APC K1310* [cytosol]
(R-HSA-9666926)
APC R499* [cytosol]
(R-HSA-9666927)
APC R1450* [cytosol]
(R-HSA-5251499)
APC G1357* [cytosol]
(R-HSA-9666940)
APC L1488* [cytosol]
(R-HSA-9666941)
APC S1400* [cytosol]
(R-HSA-9666942)
APC S1346* [cytosol]
(R-HSA-9666943)
APC R405* [cytosol]
(R-HSA-9666936)
APC S1281* [cytosol]
(R-HSA-9666937)
APC E1573* [cytosol]
(R-HSA-9666938)
APC R805* [cytosol]
(R-HSA-9666939)
APC R1386* [cytosol]
(R-HSA-9666932)
APC S1327* [cytosol]
(R-HSA-9666933)
APC E1209* [cytosol]
(R-HSA-9666934)
APC Q1469* [cytosol]
(R-HSA-9666935)
APC R564* [cytosol]
(R-HSA-9666928)
APC E1536* [cytosol]
(R-HSA-9666929)
APC G1288* [cytosol]
(R-HSA-9666930)
0.845
17
UniProt:P49840 GSK3A
3
GSK3A [cytosol]
(R-HSA-198326)
p-S21-GSK3A [cytosol]
(R-HSA-198352)
p-Y279-GSK3A [cytosol]
(R-HSA-9635490)
0.802
6
UniProt:O15169 AXIN1
11
AXIN1 L396M [cytosol]
(R-HSA-5251503)
AXIN1 Y346* [cytosol]
(R-HSA-4839753)
AXIN1 E406* [cytosol]
(R-HSA-5251500)
AXIN1 W247* [cytosol]
(R-HSA-5251512)
AXIN1 P354L [cytosol]
(R-HSA-5251511)
AXIN1 P255S [cytosol]
(R-HSA-5251505)
ub-AXIN1 [cytosol]
(R-HSA-4641133)
Ub-RibC-AXIN1 [cytosol]
(R-HSA-3640864)
RibC-AXIN1 [cytosol]
(R-HSA-3640841)
p-T481,S486,S493-AXIN1 [cytosol]
(R-HSA-206040)
AXIN1 [cytosol]
(R-HSA-195249)
0.782
5
UniProt:Q5JTC6 AMER1
5
AMER1 [cytosol]
(R-HSA-1504189)
AMER1 R353* [cytosol]
(R-HSA-9663939)
AMER1 R358* [cytosol]
(R-HSA-4839640)
AMER1 S210* [cytosol]
(R-HSA-5251492)
AMER1 R497* [cytosol]
(R-HSA-9663943)
0.708
7
UniProt:P49674 CSNK1E
2
CSNK1E [nucleoplasm]
(R-HSA-421306)
CSNK1E [cytosol]
(R-HSA-205877)
0.687
5
UniProt:P14923 JUP
6
JUP [cytosol]
(R-HSA-201598)
JUP [cornified envelope]
(R-HSA-8847739)
JUP [specific granule lumen]
(R-HSA-6799534)
JUP [extracellular region]
(R-HSA-6806309)
JUP [ficolin-1-rich granule lumen]
(R-HSA-6801028)
JUP [plasma membrane]
(R-HSA-437260)
0.666
4
UniProt:P48729 CSNK1A1
2
CSNK1A1 [cytosol]
(R-HSA-195263)
CSNK1A1 [cilium]
(R-HSA-5632507)
0.643
4
UniProt:P67775 PPP2CA
4
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
PPP2CA [nucleoplasm]
(R-HSA-165978)
PPP2CA [cytosol]
(R-HSA-165971)
0.643
4
UniProt:Q9H7D7 WDR26
1
WDR26 [cytosol]
(R-HSA-9861584)
0.641
4
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.623
10
UniProt:O14641 DVL2
5
pp-DVL2 [cytosol]
(R-HSA-3772398)
p-DVL2 [cytosol]
(R-HSA-201706)
p-DVL2 [clathrin-coated endocytic vesicle]
(R-HSA-5138444)
DVL2 [cytosol]
(R-HSA-201694)
ub-DVL2 [cytosol]
(R-HSA-4652689)
0.59
3
UniProt:Q9UKB1 FBXW11
1
FBXW11 [cytosol]
(R-HSA-976035)
0.558
4
UniProt:Q7Z699 SPRED1
2
SPRED1 [plasma membrane]
(R-HSA-5658225)
SPRED1 [cytosol]
(R-HSA-5654207)
0.556
3
UniProt:Q9BQ66 KR412
0.556
3
UniProt:Q99750 MDFI
0.556
3
UniProt:Q96KG9-4 SCYL1
0.556
3
UniProt:O94972 TRIM37
1
TRIM37 [cytosol]
(R-HSA-976049)
0.556
3
UniProt:Q9C019 TRI15
0.556
3
UniProt:Q9UJV3-2 MID2
0.556
3
UniProt:Q969G2 LHX4
1
LHX4 [nucleoplasm]
(R-HSA-9010585)
0.556
3
IntAct:EBI-16436498 CCSB ORF ID
0.556
3
UniProt:Q9BYR5 KRTAP4-2
1
KRTAP4-2 [cytosol]
(R-HSA-6809948)
0.556
3
UniProt:Q9H257-2 CARD9
0.556
3
UniProt:Q13137 CACO2
0.556
3
UniProt:Q5JR59-3 MTUS2
0.556
3
UniProt:O43586 PSTPIP1
1
PSTPIP1 [cytosol]
(R-HSA-879220)
0.556
3
IntAct:EBI-16436244 CCSB ORF ID
0.556
3
IntAct:EBI-16434222 CCSB ORF ID
0.556
3
UniProt:O75558 STX11
0.556
3
UniProt:Q96K21-3 ZFYVE19
0.556
3
UniProt:Q2TAC2-2 CCDC57
0.556
3
IntAct:EBI-16437007 CCSB ORF ID
0.556
3
IntAct:EBI-16429620 CCSB ORF ID
0.556
3
UniProt:Q15654 TRIP6
0.556
6
UniProt:Q9HCK0 ZBT26
0.556
3
UniProt:G2XKQ0 SUMO5
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q6A162 KRT40
1
KRT40 [cytosol]
(R-HSA-6809605)
0.556
3
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
SUMO1 [nucleoplasm]
(R-HSA-877304)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:O15105 SMAD7
2
SMAD7 [nucleoplasm]
(R-HSA-178197)
SMAD7 [cytosol]
(R-HSA-173478)
0.556
8
UniProt:Q12933 TRAF2
5
TRAF2 [nucleoplasm]
(R-HSA-8862199)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
TRAF2 [cytosol]
(R-HSA-66370)
0.556
3
UniProt:Q9UBB9 TFIP11
1
TFIP11 [nucleoplasm]
(R-HSA-8869310)
0.556
3
UniProt:Q08379 GOLGA2
3
p-S37-GOLGA2 [Golgi membrane]
(R-HSA-2172179)
GOLGA2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-2167933)
GOLGA2 [Golgi membrane]
(R-HSA-6808764)
0.556
3
UniProt:Q15172 PPP2R5A
2
p-S28-PPP2R5A [cytosol]
(R-HSA-9836658)
PPP2R5A [cytosol]
(R-HSA-196235)
0.527
2
UniProt:Q93008 USP9X
1
USP9X [cytosol]
(R-HSA-870499)
0.527
2
UniProt:O75581 LRP6
8
p-T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-205884)
p-S1490-LRP6 [plasma membrane]
(R-HSA-206156)
LRP6 [early endosome membrane]
(R-HSA-5368481)
p-LRP6 [early endosome membrane]
(R-HSA-5368496)
LRP6N [extracellular region]
(R-HSA-5334021)
p-2S,S1490,2T-LRP6 [plasma membrane]
(R-HSA-1458894)
p-4S,3T,T1479,S1490,T1493-LRP6 [plasma membrane]
(R-HSA-1458895)
LRP6 [plasma membrane]
(R-HSA-206252)
0.527
9
IntAct:EBI-11789122 GSK3A
0.525
2
UniProt:G1T8E2 G1T8E2
0.525
2
UniProt:Q92837 FRAT1
1
FRAT1 [cytosol]
(R-HSA-1226051)
0.525
3
UniProt:Q5VWQ8-2 DAB2IP
0.524
2
UniProt:P62136 PPP1CA
1
PPP1CA [cytosol]
(R-HSA-163525)
0.524
4
UniProt:P04637 TP53
20
Unfolded TP53 [cytosol]
(R-HSA-6813797)
TP53 [cytosol]
(R-HSA-8869337)
PolyUb-TP53 [nucleoplasm]
(R-HSA-6782509)
polySUMO2,3-K386-TP53 [nucleoplasm]
(R-HSA-2997661)
TP53 F341C [nucleoplasm]
(R-HSA-9726318)
TP53 G334V [nucleoplasm]
(R-HSA-9726126)
TP53 L330H [nucleoplasm]
(R-HSA-9726124)
TP53 A347T [nucleoplasm]
(R-HSA-9726339)
TP53 R337C [nucleoplasm]
(R-HSA-9726118)
TP53 L344P [nucleoplasm]
(R-HSA-9726075)
TP53 L344R [nucleoplasm]
(R-HSA-9726073)
TP53 R337H [nucleoplasm]
(R-HSA-9726169)
TP53 R337P [nucleoplasm]
(R-HSA-9726168)
TP53 L330P [nucleoplasm]
(R-HSA-9726136)
TP53 L348S [nucleoplasm]
(R-HSA-9726366)
TP53 R337L [nucleoplasm]
(R-HSA-9726163)
TP53 K351E [nucleoplasm]
(R-HSA-9726258)
TP53 F338I [nucleoplasm]
(R-HSA-9726358)
TP53 R342P [nucleoplasm]
(R-HSA-9726101)
TP53 L330R [nucleoplasm]
(R-HSA-9726133)
0.524
4
UniProt:P23258 TUBG1
1
TUBG1 [cytosol]
(R-HSA-379269)
0.512
4
UniProt:Q14194 CRMP1
4
p-Y-CRMP1 [cytosol]
(R-HSA-399784)
CRMP1 [cytosol]
(R-HSA-398120)
p-T509,T514,S518,S522-CRMP1 [cytosol]
(R-HSA-399777)
p-S522-CRMP1 [cytosol]
(R-HSA-399779)
0.508
2
UniProt:P39687 ANP32A
1
ANP32A [nucleoplasm]
(R-HSA-450467)
0.508
2
UniProt:Q15583 TGIF1
1
TGIF1 [nucleoplasm]
(R-HSA-2186594)
0.499
4
UniProt:Q60953-2 PML
0.499
2
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.499
2
UniProt:P46937 YAP1
8
p-Y407-YAP1 [cytosol]
(R-HSA-9865208)
p-S127-YAP1 [cytosol]
(R-HSA-2028553)
p-5S-YAP1 [cytosol]
(R-HSA-2028554)
p-Y407-YAP1 [nucleoplasm]
(R-HSA-8956661)
p-Y-YAP1 [cytosol]
(R-HSA-8937843)
p-Y-YAP1 [nucleoplasm]
(R-HSA-8937857)
YAP1 [cytosol]
(R-HSA-1253345)
YAP1 [nucleoplasm]
(R-HSA-1253322)
0.499
11
UniProt:P35813 PPM1A
2
PPM1A [cytosol]
(R-HSA-380928)
PPM1A [nucleoplasm]
(R-HSA-205813)
0.499
2
UniProt:Q99ML9 Rnf111
3
RNF111 [cytosol]
(R-MMU-975981)
Rnf111 [nucleoplasm]
(R-MMU-2186735)
RNF111 [nucleoplasm]
(R-MMU-2186765)
0.463
5
UniProt:P29590 PML
5
polySUMO3-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000386)
polySUMO2-K65,K160,K490-PML [nucleoplasm]
(R-HSA-3000423)
monoSUMO1-K65,160,490-PML [nucleoplasm]
(R-HSA-3000440)
PML [nucleoplasm]
(R-HSA-1031706)
PML [cytosol]
(R-HSA-5624327)
0.463
2
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