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ub-pS-GLI1 [ciliary base]
Stable Identifier
R-HSA-5610514
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ciliary base
Synonyms
PKA-phosphorylated GLI1, Zinc finger protein GLI1, GLI1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'off' state (Homo sapiens)
Degradation of GLI1 by the proteasome (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by ITCH (Homo sapiens)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Homo sapiens)
ub-pS-GLI1 [ciliary base] (Homo sapiens)
GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP (Homo sapiens)
ub-pS-GLI1:SUFU [ciliary base] (Homo sapiens)
ub-pS-GLI1 [ciliary base] (Homo sapiens)
NUMB:ITCH bind and ubiquitnate GLI1 (Homo sapiens)
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Homo sapiens)
ub-pS-GLI1 [ciliary base] (Homo sapiens)
SCF(beta-TrCP) ubiquitinates p-GLI1 (Homo sapiens)
ub-pS-GLI1:SUFU [ciliary base] (Homo sapiens)
ub-pS-GLI1 [ciliary base] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08151 GLI1
Gene Names
GLI1, GLI
Chain
chain:1-1106
Reference Genes
COSMIC (genes):GLI1 GLI1
dbSNP Gene:2735 GLI1
ENSEMBL:ENSG00000111087 GLI1
Participates
as a component of
NUMB:ITCH:ub-pS-GLI1:SUFU [cytosol] (Homo sapiens)
ub-pS-GLI1:SUFU [ciliary base] (Homo sapiens)
Other forms of this molecule
ub-GLI1 [cytosol]
pS-GLI1 [ciliary base]
GLI1 [cytosol]
p-GLI1 [ciliary tip]
2p-GLI1 [nucleoplasm]
p-GLI1 [nucleoplasm]
GLI1 [ciliary base]
GLI1 [ciliary tip]
Inferred To
phospho-ub-pS-GLI1 [ciliary base]
(Gallus gallus)
phospho-Gli1 [ciliary base]
(Mus musculus)
phospho-Gli1 [ciliary base]
(Rattus norvegicus)
phospho-ci [ciliary base]
(Drosophila melanogaster)
phospho-gli1 [ciliary base]
(Xenopus tropicalis)
Ghost homologue of ub-pS-GLI1 [ciliary base]
(Danio rerio)
phospho-GLI1 [ciliary base]
(Bos taurus)
phospho-GLI1 [ciliary base]
(Canis familiaris)
phospho-GLI1 [ciliary base]
(Sus scrofa)
Modified Residues
Name
O-phospho-L-serine at unknown position
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine at unknown position
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Interactors (15)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UMX1 SUFU
3
SUFU [ciliary base]
(R-HSA-5610424)
SUFU [cytosol]
(R-HSA-445455)
SUFU [ciliary tip]
(R-HSA-5610426)
0.968
27
UniProt:Q9QZS3-2 NUMB
0.611
4
UniProt:Q96J02 ITCH
2
Ub-C871-ITCH [cytosol]
(R-HSA-8864515)
ITCH [cytosol]
(R-HSA-975995)
0.602
4
UniProt:Q9UMX1-2 SUFU
0.571
4
UniProt:Q96CN9 GCC1
1
GCC1 [cytosol]
(R-HSA-6813877)
0.556
3
UniProt:P54646 PRKAA2
4
PRKAA2 [cytosol]
(R-HSA-200405)
p-T172-PRKAA2 [cytosol]
(R-HSA-200417)
p-T172-PRKAA2 [nucleoplasm]
(R-HSA-164171)
PRKAA2 [nucleoplasm]
(R-HSA-163682)
0.556
3
UniProt:Q13526 PIN1
2
PIN1 [nucleoplasm]
(R-HSA-936016)
PIN1 [cytosol]
(R-HSA-9626823)
0.556
3
UniProt:Q8IWZ5 TRI42
0.556
3
UniProt:P29972 AQP1
1
AQP1 [plasma membrane]
(R-HSA-431700)
0.556
3
UniProt:P53673 CRBA4
0.556
3
UniProt:Q8NEC5 CATSPER1
1
CATSPER1 [plasma membrane]
(R-HSA-2534335)
0.556
3
UniProt:P23443-2 RPS6KB1
0.544
2
UniProt:Q9NRP7 STK36
0.536
2
UniProt:P46684 ZIC1
0.524
2
UniProt:P40337 VHL
3
monoSUMO1-K159,171,196-VHL [nucleoplasm]
(R-HSA-4551697)
VHL [nucleoplasm]
(R-HSA-1234127)
VHL [cytosol]
(R-HSA-391423)
0.463
2
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