Reactome | ub-pS-GLI1 [ciliary base]

ub-pS-GLI1 [ciliary base]

Stable Identifier

R-HSA-5610514

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ciliary base

Synonyms

PKA-phosphorylated GLI1, Zinc finger protein GLI1, GLI1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P08151 GLI1

Gene Names

GLI1, GLI

Chain

chain:1-1106

Reference Genes

BioGPS Gene:2735 GLI1

COSMIC (genes):GLI1 GLI1

CTD Gene:2735 GLI1

dbSNP Gene:2735 GLI1

ENSEMBL:ENSG00000111087 GLI1

HGNC:4317 GLI1

KEGG:hsa:2735 GLI1

Monarch:2735 GLI1

NCBI Gene:2735 GLI1

OMIM:165220 GLI1

UCSC:P08151 GLI1

Reference Transcript

Participates

as a component of

Other forms of this molecule

GLI1 [ciliary tip]

GLI1 [ciliary base]

p-GLI1 [nucleoplasm]

2p-GLI1 [nucleoplasm]

p-GLI1 [ciliary tip]

GLI1 [cytosol]

ub-GLI1 [cytosol]

pS-GLI1 [ciliary base]

Inferred To

phospho-Gli1 [ciliary base] (Mus musculus)

phospho-Gli1 [ciliary base] (Rattus norvegicus)

phospho-ci [ciliary base] (Drosophila melanogaster)

phospho-gli1 [ciliary base] (Danio rerio)

phospho-gli1 [ciliary base] (Xenopus tropicalis)

phospho-GLI1 [ciliary base] (Bos taurus)

phospho-GLI1 [ciliary base] (Canis familiaris)

phospho-GLI1 [ciliary base] (Gallus gallus)

phospho-GLI1 [ciliary base] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at unknown position

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001161081.1, XP_011536491.1, NP_005260.1, NP_001153517.1

OpenTargets

ENSG00000111087

ENSEMBL

ENSG00000111087, ENST00000528467, ENSP00000434408, ENST00000543426, ENSP00000228682, ENST00000546141, ENSP00000437607, ENSP00000441006, ENST00000228682

ZINC - Substances

GLI1_HUMAN

ZINC - Biogenic

GLI1_HUMAN

ZINC target

P08151

PRO

P08151

GlyGen

P08151

PDB

5OM0, 4KMD, 2GLI, 7T91, 4BLB

HPA

ENSG00000111087-GLI1

GeneCards

GLI1

Pharos - Targets

P08151

Orphanet

GLI1

ZINC - Predictions - Purchasable

GLI1_HUMAN

Interactors (15)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UMX1 SUFU	3	SUFU [ciliary base] (R-HSA-5610424) SUFU [cytosol] (R-HSA-445455) SUFU [ciliary tip] (R-HSA-5610426)	0.968	27
UniProt:Q9QZS3-2 NUMB			0.611	4
UniProt:Q96J02 ITCH	2	ITCH [cytosol] (R-HSA-975995) Ub-C871-ITCH [cytosol] (R-HSA-8864515)	0.602	4
UniProt:Q9UMX1-2 SUFU			0.571	4
UniProt:Q13526 PIN1	2	PIN1 [nucleoplasm] (R-HSA-936016) PIN1 [cytosol] (R-HSA-9626823)	0.556	3
UniProt:Q8NEC5 CATSPER1	1	CATSPER1 [plasma membrane] (R-HSA-2534335)	0.556	3
UniProt:P53673 CRBA4			0.556	3
UniProt:P29972 AQP1	1	AQP1 [plasma membrane] (R-HSA-431700)	0.556	3
UniProt:Q8IWZ5 TRI42			0.556	3
UniProt:P54646 PRKAA2	5	PRKAA2 [cytosol] (R-HSA-200405) p-T172-PRKAA2 [cytosol] (R-HSA-200417) p-T172-PRKAA2 [nucleoplasm] (R-HSA-164171) p-T172-PRKAA2 [endoplasmic reticulum lumen] (R-HSA-9931258) PRKAA2 [nucleoplasm] (R-HSA-163682)	0.556	3
UniProt:Q96CN9 GCC1	1	GCC1 [cytosol] (R-HSA-6813877)	0.556	3
UniProt:P23443-2 RPS6KB1			0.544	2
UniProt:Q9NRP7 STK36			0.536	2
UniProt:P46684 ZIC1			0.524	2
UniProt:P40337 VHL	3	VHL [cytosol] (R-HSA-391423) VHL [nucleoplasm] (R-HSA-1234127) monoSUMO1-K159,171,196-VHL [nucleoplasm] (R-HSA-4551697)	0.463	2

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