Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
monoSUMO1-K7,K388,K531-PGR [nucleoplasm]
Stable Identifier
R-HSA-4341032
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Progesterone receptor, PRGR_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS3 SUMOylates PGR with SUMO1 (Homo sapiens)
monoSUMO1-K7,K388,K531-PGR [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P06401 PGR
Gene Names
PGR, NR3C3
Chain
chain:1-933
Reference Genes
BioGPS Gene:5241 PGR
COSMIC (genes):PGR PGR
CTD Gene:5241 PGR
dbSNP Gene:5241 PGR
ENSEMBL:ENSG00000082175 PGR
HGNC:8910 PGR
KEGG Gene (Homo sapiens):5241 PGR
Monarch:5241 PGR
NCBI Gene:5241 PGR
OMIM:607311 PGR
UCSC:P06401 PGR
Reference Transcript
RefSeq:NM_001271162.1 PGR
RefSeq:NM_001202474.3 PGR
RefSeq:NM_001271161.2 PGR
RefSeq:NM_000926.4 PGR
Other Identifiers
0101990537
11726167_a_at
11726168_at
11750900_a_at
11750901_x_at
160021_r_at
16743577
208305_at
228554_at
3388369
3388370
3388371
3388372
3388373
3388374
3388375
3388376
3388377
3388378
3388379
3388380
3388382
3388383
3388387
3388393
3388407
3388408
3388410
3388411
3388412
3388413
3388414
3388415
426_at
44598_at
5241
7951165
81847_at
83526_at
A_23_P138938
A_32_P49199
GE59760
GE630055
GE900767
GO:0000003
GO:0000785
GO:0000978
GO:0000981
GO:0001225
GO:0001228
GO:0001542
GO:0002070
GO:0003674
GO:0003677
GO:0003700
GO:0003707
GO:0004879
GO:0005102
GO:0005496
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005739
GO:0005741
GO:0005829
GO:0006355
GO:0006357
GO:0006367
GO:0007165
GO:0007267
GO:0008134
GO:0008150
GO:0008270
GO:0008283
GO:0008289
GO:0009058
GO:0010629
GO:0016020
GO:0019899
GO:0021700
GO:0030154
GO:0030518
GO:0030879
GO:0034641
GO:0038001
GO:0042802
GO:0043167
GO:0043226
GO:0043401
GO:0043565
GO:0045944
GO:0046872
GO:0048286
GO:0048856
GO:0050678
GO:0050847
GO:0051117
GO:0060748
HMNXSV003001822
HMNXSV003041440
Hs.32405.0.S1_3p_at
ILMN_1811014
PH_hs_0000369
PH_hs_0002738
TC11002220.hg
TC11003308.hg
TC11003309.hg
X51730_at
g4505766_3p_at
Participates
as an output of
PIAS3 SUMOylates PGR with SUMO1 (Homo sapiens)
Other forms of this molecule
PGR [cytosol]
PGR [nucleoplasm]
Inferred To
pgr [nucleoplasm]
(Danio rerio)
pgr [nucleoplasm]
(Xenopus tropicalis)
PGR [nucleoplasm]
(Gallus gallus)
Pgr [nucleoplasm]
(Mus musculus)
Pgr [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 7
Coordinate
7
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 388
Coordinate
388
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 531
Coordinate
531
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001189403.1
,
NP_000917.3
,
NP_001258090.1
,
NP_001258091.1
ZINC - World Drugs
PRGR_HUMAN
Guide to Pharmacology - Targets
627
OpenTargets
ENSG00000082175
ZINC - FDA approved
PRGR_HUMAN
ZINC - Substances
PRGR_HUMAN
ZINC - Biogenic
PRGR_HUMAN
ZINC target
P06401
PRO
P06401
GlyGen
P06401
PDB
1SR7
,
3ZRB
,
3G8O
,
2OVM
,
3ZRA
,
1E3K
,
2C7A
,
3D90
,
1SQN
,
3KBA
,
2W8Y
,
1ZUC
,
4A2J
,
2OVH
,
3HQ5
,
5CC0
,
3ZR7
,
1A28
,
4APU
,
4OAR
ZINC - Investigational
PRGR_HUMAN
ZINC - Metabolites
PRGR_HUMAN
HPA
ENSG00000082175-PGR
GeneCards
P06401
Ensembl
ENSG00000082175
,
ENST00000325455
,
ENST00000534013
,
ENSP00000325120
,
ENST00000263463
,
ENSP00000263463
,
ENSP00000436561
Pharos - Targets
P06401
Orphanet
24806
ZINC - Predictions - Purchasable
PRGR_HUMAN
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.774
20
UniProt:Q9H467 CUED2
0.66
9
UniProt:P06401 PGR
3
monoSUMO1-K7,K388,K531-PGR [nucleoplasm]
(R-HSA-4341032)
PGR [cytosol]
(R-HSA-8948964)
PGR [nucleoplasm]
(R-HSA-3008952)
0.623
2
UniProt:P40763 STAT3
12
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
p-STAT3 [cytosol]
(R-HSA-8982823)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
0.623
3
IntAct:EBI-2119323 CCND1
0.527
5
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.462
2
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text