Reactome | p-S20-MYL6B [cytosol]

p-S20-MYL6B [cytosol]

Stable Identifier

R-HSA-445763

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphorylated Myosin light chain 6B, MYL6B, MYL6B_HUMAN

Locations in the PathwayBrowser

Expand all

Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ADP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6B [cytosol] (Homo sapiens)
    - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6B [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6B [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6B [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6B [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6B [cytosol] (Homo sapiens)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6B [cytosol] (Homo sapiens)
  - Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)
    - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
      - p-S20-MYL6B [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ADP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6B [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL6B [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14649 MYL6B

Gene Names

MYL6B, MLC1SA

Chain

chain:1-208

Reference Genes

BioGPS Gene:140465 MYL6B

COSMIC (genes):MYL6B MYL6B

CTD Gene:140465 MYL6B

dbSNP Gene:140465 MYL6B

ENSEMBL:ENSG00000196465 MYL6B

HGNC:29823 MYL6B

KEGG:hsa:140465 MYL6B

Monarch:140465 MYL6B

NCBI Gene:140465 MYL6B

OMIM:609930 MYL6B

UCSC:P14649 MYL6B

Reference Transcript

Other Identifiers

11716794_a_at

11744400_a_at

11747439_a_at

11753991_x_at

11760908_at

140465

16752542

204173_PM_at

204173_at

212082_PM_s_at

212082_s_at

3417436

3417437

3417438

3417439

3417440

3417441

3417442

3417443

3417444

3417445

3417446

3417447

3417448

3417449

3417450

3417451

3417452

3417453

3417454

3417456

3417458

3417459

3417460

3417461

3417462

3417463

3417465

3417466

3417467

3417468

3417469

3417470

3417471

3417472

3417473

38251_at

7956200

7956211

89570_f_at

A_14_P113460

A_14_P115597

A_23_P2223

A_23_P344973

GE499816

GE79245

GE82578

GE85290

GO:0003012

GO:0003774

GO:0005198

GO:0005509

GO:0005515

GO:0005829

GO:0005859

GO:0006936

GO:0007519

GO:0008307

GO:0016459

GO:0016460

GO:0016461

GO:0030049

GO:0043226

GO:0048856

GO:0070062

HMNXSV003029408

ILMN_1713450

M31211_s_at

PH_hs_0005045

TC12003246.hg

g4505302_3p_at

p33402

Participates

as a member of

Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)

Other forms of this molecule

MYL6B [cytosol]

Inferred To

phospho-Myl6b [cytosol] (Mus musculus)

phospho-p-S20-MYL6B [cytosol] (Plasmodium falciparum)

phospho-Dmel\CG17237 [cytosol] (Drosophila melanogaster)

phospho-mlc-6 [cytosol] (Caenorhabditis elegans)

phospho-MYL6 [cytosol] (Gallus gallus)

phospho-mlc-7 [cytosol] (Caenorhabditis elegans)

phospho-MYL6B [cytosol] (Bos taurus)

phospho-MYL6B [cytosol] (Canis familiaris)

phospho-mlc-3 [cytosol] (Caenorhabditis elegans)

phospho-MLC1 [cytosol] (Saccharomyces cerevisiae)

phospho-cdc4 [cytosol] (Schizosaccharomyces pombe)

phospho-Dmel\CG34435 [cytosol] (Drosophila melanogaster)

phospho-mlcE [cytosol] (Dictyostelium discoideum)

phospho-Mlc-c [cytosol] (Drosophila melanogaster)

phospho-myl6 [cytosol] (Danio rerio)

phospho-myl6 [cytosol] (Xenopus tropicalis)

Homologues of p-S20-MYL6B [cytosol] (Caenorhabditis elegans)

Homologues of p-S20-MYL6B [cytosol] (Drosophila melanogaster)

Homologues of p-S20-MYL6B [cytosol] (Plasmodium falciparum)

phospho-Mlc1 [cytosol] (Drosophila melanogaster)

phospho-mlc-5 [cytosol] (Caenorhabditis elegans)

Modified Residues

Name

O-phospho-L-serine at 20

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_001186558.1, NP_002466.1

OpenTargets

ENSG00000196465

ENSEMBL

ENSP00000512320, ENSP00000450385, ENSG00000196465, ENST00000553066, ENST00000550443, ENST00000695999, ENSP00000446643

HPA

ENSG00000196465-MYL6B

GeneCards

MYL6B

PRO

P14649

Pharos - Targets

P14649

GlyGen

P14649

HMDB Protein

HMDBP07825

PDB

7PLT, 7PLV, 7PLU, 7PM6, 7PM0, 7PM7, 7PM5, 7PMF, 7PMD, 7PLY, 7PMA, 7PLW, 7PMC, 7PMG, 7PME, 7PM8, 7PM2, 7PM1, 7PMB, 7PML, 7PM9, 7PMI, 7PLZ, 7PMH, 7PMJ, 7PLX, 1W7I, 1W7J, 1OE9

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.638	3
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.527	2
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.527	4
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.482	2

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