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About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
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Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
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ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
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fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
Stable Identifier
R-COV-9696997
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum-Golgi intermediate compartment
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Late SARS-CoV-2 Infection Events (Homo sapiens)
Translation of Structural Proteins (Homo sapiens)
Maturation of spike protein (Homo sapiens)
Addition of sialic acids on some Spike glycosyl sidechains (Homo sapiens)
fully glycosylated Spike trimer [endoplasmic reticulum-Golgi intermediate compartment] (Severe acute respiratory syndrome coronavirus 2)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (Severe acute respiratory syndrome coronavirus 2)
Spike trimer moves into the ERGIC membrane (Homo sapiens)
fully glycosylated Spike trimer [endoplasmic reticulum-Golgi intermediate compartment] (Severe acute respiratory syndrome coronavirus 2)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (Severe acute respiratory syndrome coronavirus 2)
Literature References
PubMed ID
Title
Journal
Year
32366695
Site-specific glycan analysis of the SARS-CoV-2 spike
Watanabe, Y
,
Crispin, M
,
Allen, JD
,
McLellan, JS
,
Wrapp, D
Science
2020
External Reference Information
External Reference
UniProt:P0DTC2 S
Gene Names
S, 2
Chain
signal peptide:1-13, chain:14-1273, chain:14-685, chain:686-1273, chain:816-1273
Reference Genes
BioGPS Gene:43740568 S
Monarch:43740568 S
NCBI Gene:43740568 S
UCSC:P0DTC2 S
Reference Transcript
RefSeq:NC_045512.2 S
Participates
as a component of
fully glycosylated Spike trimer [endoplasmic reticulum-Golgi intermediate compartment] (Severe acute respiratory syndrome coronavirus 2)
Other forms of this molecule
S(686-815) [plasma membrane]
Spike S2' Fragment [plasma membrane]
S1 [plasma membrane]
fully glycosylated Spike [plasma membrane]
nascent Spike [endoplasmic reticulum lumen]
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
fully glycosylated Spike [virion membrane]
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
Modified Residues
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1074
Coordinate
1074
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 122
Coordinate
122
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 603
Coordinate
603
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 61
Coordinate
61
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 709
Coordinate
709
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 717
Coordinate
717
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 801
Coordinate
801
Modification
high-mannose N-glycan-yl group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (Man(9) N-glycan group) at 234
Coordinate
234
Modification
Man(9) N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
palmitoylated-L-cysteine at unknown position
PsiMod Name
palmitoylated-L-cysteine
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1098
Coordinate
1098
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1134
Coordinate
1134
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1173
Coordinate
1173
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 149
Coordinate
149
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 165
Coordinate
165
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 17
Coordinate
17
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 282
Coordinate
282
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 331
Coordinate
331
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 343
Coordinate
343
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 616
Coordinate
616
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 657
Coordinate
657
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 74
Coordinate
74
Modification
tri-antennary complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (sialylated complex N-glycan group) at 1158
Coordinate
1158
Modification
sialylated complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (sialylated complex N-glycan group) at 1194
Coordinate
1194
Modification
sialylated complex N-glycan group
PsiMod Name
N4-(N-acetylamino)glucosyl-L-asparagine
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
RefSeq
YP_009724390.1
GlyGen
P0DTC2
PDB
7BNV
,
7R1A
,
7XSC
,
7XMX
,
7PBE
,
7KNH
,
8AQU
,
7L2D
,
7ORB
,
6XKQ
,
7XIK
,
7X94
,
7DWZ
,
7CH5
,
7WD7
,
7V7A
,
7KSG
,
7R13
,
7W9C
,
7WUH
,
7WA1
,
8VQR
,
7KE8
,
7RQ6
,
7KN6
,
7FDK
,
7EZV
,
7P5S
,
8R1D
,
7UPY
,
7F6Y
,
8IVA
,
7WSE
,
7SXY
,
7KFY
,
7FB0
,
8GNH
,
8DTT
,
6VSB
,
7OAY
,
7KDJ
,
7PQY
,
7K8M
,
7WP1
,
7V88
,
8CIN
,
7RNJ
,
7YTN
,
8GTP
,
7CZT
,
8DNN
,
8JYM
,
7YQZ
,
9FGU
,
7BEI
,
7NX8
,
6X79
,
7D4G
,
7N1F
,
7SBU
,
8SMI
,
7NDA
,
7ZJL
,
7M8J
,
7V77
,
8DLO
,
6ZP1
,
7ZSS
,
7MY2
,
7A5S
,
7Q9M
,
7YBH
,
6XRA
,
7Z0X
,
8HQT
,
8DM4
,
7R4I
,
7N8I
,
8G79
,
8J1Q
,
7M0J
,
7VNC
,
7N6E
,
7M6F
,
7PS5
,
7D03
,
7DZY
,
8CY7
,
7U9O
,
7DX8
,
7Y8J
,
7Y21
,
8EPP
,
7E9T
,
7EDI
,
7KXK
,
8HN6
,
8OWT
,
7Y7K
,
7Y0N
,
6XM3
,
8BG3
,
7FC5
,
7XU1
,
7WZ1
,
7SL5
,
7P7B
,
7NTA
,
7E86
,
7DET
,
7TP1
,
7SOC
,
7Y6N
,
8IX3
,
7WCH
,
7DX6
,
7MJM
,
7CHP
,
8ASY
,
7WHB
,
8RH6
,
8FEZ
,
8DV1
,
7W9B
,
7XEG
,
8DXT
,
7V7D
,
7KMI
,
8BBN
,
7V8B
,
7THE
,
7YV8
,
7KJ5
,
7WTJ
,
7SXR
,
7EYA
,
6Z2M
,
8DPZ
,
7SJ0
,
7TGE
,
8ELO
,
8ZC4
,
7T7B
,
8QTD
,
7WCZ
,
8VKO
,
7TCC
,
7T67
,
7RU2
,
7V86
,
7ND5
,
7DK4
,
7TP7
,
7WHH
,
8V0R
,
7F63
,
7ME7
,
7SY7
,
7URS
,
7MZK
,
8HC8
,
7E3O
,
7CZS
,
7VRV
,
7WK8
,
7LY3
,
6VW1
,
7UKL
,
7YVL
,
7CYV
,
7N3I
,
7ENF
,
7UB0
,
7X2L
,
7A5R
,
8G71
,
8CBE
,
8KC2
,
7XXL
,
8C3V
,
8SIT
,
7WPH
,
8CXN
,
7PKI
,
8KA8
,
7BEJ
,
7M6D
,
7PS6
,
8GB6
,
7N9B
,
8DI5
,
7DX0
,
8GF2
,
7Y75
,
7EJY
,
7DD8
,
7N8H
,
8CSJ
,
8DM2
,
7WNM
,
7LX5
,
7EDG
,
8HSM
,
7FAU
,
7WGV
,
8BG2
,
7EFP
,
8CWK
,
6LZG
,
7MM0
,
7TLD
,
8WLO
,
7R16
,
7DX9
,
8WRO
,
7SN3
,
7WWL
,
7MJK
,
7MF1
,
7FCQ
,
8BG6
,
7Y1Z
,
7KMH
,
8DXS
,
7WGY
,
7C8V
,
7V89
,
7TGX
,
8BEV
,
8JJE
,
7XOA
,
7KRR
,
8IV4
,
7S6J
,
8UUL
,
7FET
,
7WRZ
,
7SY1
,
7S83
,
7F5G
,
7W9F
,
7CAI
,
7CDI
,
7SIS
,
7KKK
,
8E1G
,
7WVP
,
7WD9
,
8DMA
,
7KN4
,
7NS6
,
7S5R
,
8GX9
,
7UL0
,
7SI2
,
8SK5
,
7DPM
,
7T72
,
8V0V
,
7YVG
,
7YR3
,
7C8D
,
7DMU
,
7LYL
,
7WK0
,
8H6F
,
7SWW
,
8GRY
,
7NXB
,
7YDI
,
8C89
,
7EAZ
,
8G75
,
7K8W
,
7LWO
,
8V0L
,
7EKG
,
7X1M
,
7CWN
,
7V83
,
7PS1
,
7D30
,
7TPA
,
8J26
,
7N64
,
8HPQ
,
7EB0
,
7M3I
,
7MW2
,
7QUR
,
7LQW
,
8IOS
,
8I4F
,
7M8U
,
6ZER
,
8WOY
,
7EJL
,
7ZCF
,
8DM8
,
7UHC
,
8XEA
,
7PHG
,
8A95
,
8I3U
,
7N1U
,
8BSF
,
7EJ5
,
7ZF3
,
8CYA
,
7BNO
,
6Z97
,
7MY3
,
8DF5
,
7DX7
,
7CN9
,
6X6P
,
7Y20
,
7UZD
,
7R4R
,
7RA8
,
7Y6D
,
7EDH
,
7CM4
,
7CHC
,
7SOB
,
8OWW
,
6XM4
,
7L7E
,
7WDF
,
6YZ5
,
7WZ2
,
7JZL
,
7QNY
,
7BZ5
,
7UZ7
,
7WS3
,
6XE1
,
6XCN
,
7TF1
,
8AQV
,
7XOC
,
7EY4
,
7CAC
,
7X92
,
7JJC
,
7K9I
,
7WG7
,
7L02
,
7VYR
,
7R11
,
7WVO
,
6XC3
,
7XIX
,
7XDA
,
7RKU
,
7VXI
,
7P79
,
7V7O
,
7JJI
,
7C53
,
8QSQ
,
7L4Z
,
7Z7X
,
7VX1
,
7SY6
,
7E3L
,
7V26
,
6ZWV
,
7KGJ
,
7YVH
,
7YQU
,
7WS1
,
7TP3
,
7X2H
,
8RBU
,
7A91
,
7EKC
,
7YUE
,
7CZW
,
7LAA
,
7YCO
,
7V81
,
8CMA
,
6ZGG
,
8I9F
,
8HHX
,
7WLC
,
7BEO
,
7NX9
,
7SBQ
,
6ZCZ
,
7XU4
,
8HFY
,
7LWV
,
8V0N
,
7MZN
,
7YH6
,
8DM6
,
7A4N
,
7UZA
,
8HPF
,
6ZP7
,
7LXY
,
7R95
,
7LDJ
,
8XE9
,
7DCC
,
8DM9
,
8C1V
,
8Q7S
,
8TAZ
,
7TPR
,
7RBU
,
8HRL
,
7RAQ
,
7N1W
,
8EQF
,
7JVA
,
7Z1D
,
7YC5
,
7ZF7
,
7KFV
,
7F6Z
,
7V27
,
7SY0
,
7EU2
,
8ELQ
,
7FAE
,
7UM2
,
7RZU
,
8GOM
,
7K9Z
,
7KDK
,
7JX3
,
7V7T
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,
7FG2
,
7XD2
,
8SDF
,
7VXB
,
7E5S
,
7KML
,
8WGW
,
7KLG
,
8ENX
,
7V8A
,
8IV5
,
7NKT
,
7XB1
,
8DT8
,
7KS9
,
7KJ4
,
7S0E
,
7QF0
,
7F5R
,
7WSC
,
7UOW
,
7CAN
,
8ZC3
,
7OAU
,
6XEY
,
7RZV
,
8VYF
,
7WBL
,
7KDI
,
8RCV
,
7RU5
,
7ND8
,
7V7U
,
8U1G
,
7TOV
,
7AKD
,
7DK0
,
7WHJ
,
7SXV
,
7WO4
,
9FGS
,
8H5C
,
7N1A
,
6VYB
,
7YEG
,
7SBS
,
8G70
,
8DLM
,
6WPS
,
7YVO
,
7LY2
,
7R8L
,
7X2K
,
8GB5
,
8UK1
,
7Q9K
,
8HED
,
7YDY
,
8D8R
,
7MKB
,
7LWP
,
7VHJ
,
8C0Y
,
7TPH
,
9AYX
,
7VMU
,
7ZR2
,
7Q3R
,
7WOB
,
7YBN
,
8FU8
,
8SIQ
,
7K43
,
7WOC
,
6ZP5
,
7SC1
,
8DAD
,
8HPU
,
8HLD
,
6YZ7
,
8V0Q
,
8T20
,
7DHX
,
7M8S
,
7ZFD
,
8DLU
,
7N5H
,
7E9P
,
6X29
,
7LSS
,
8CYD
,
7M7W
,
7Q0I
,
7UB5
,
8DLX
,
8GB0
,
8G7B
,
7D0B
,
7MSQ
,
8K5G
,
7DEO
,
7X8Y
,
7N1V
,
7WOG
,
7F0X
,
7ZF9
,
7PR0
,
7ZR9
,
7U0Q
,
7DWX
,
7R19
,
7SN2
,
8BG5
,
7Y1Y
,
7CHH
,
7WWK
,
7MJJ
,
7X66
,
7V78
,
8QRF
,
7NT9
,
7Y0W
,
7WHD
,
7KMG
,
7QNW
,
7JZU
,
7KJ3
,
7S6L
,
7L3N
,
7L0N
,
8ELJ
,
7RW2
,
7F5H
,
7VXF
,
6M1V
,
7CAK
,
7WGB
,
7SY4
,
8FHY
,
7TEX
,
7OAO
,
7T5O
,
7RZT
,
8VKN
,
7WBH
,
8HXJ
,
7KMS
,
7V7H
,
7RU3
,
8TMA
,
8CMB
,
7DK3
,
7TP8
,
8UUO
,
8V0X
,
8GS6
,
7YVF
,
8XLN
,
7SY8
,
7LYO
,
8GPY
,
7KGK
,
7SBK
,
7F3Q
,
7NXA
,
7PRZ
,
7K8V
,
8I5I
,
8KHD
,
7CWM
,
8G74
,
7LWN
,
7D2Z
,
6ZDG
,
7EB5
,
8VKL
,
7V7R
,
8JYP
,
7PS0
,
7NX7
,
7N1B
,
8C8P
,
8HLC
,
7N4J
,
7MEJ
,
8HRD
,
7SBT
,
8DLI
,
7NDC
,
7LWM
,
8T23
,
7A96
,
8HFZ
,
6ZOZ
,
7U8E
,
7LXX
,
7MZF
,
7PS4
,
7YBK
,
7MXP
,
7YJ3
,
7TLT
,
8DM3
,
8G78
,
8TYO
,
7BEL
,
7DZX
,
7U0D
,
7M6I
,
7TPE
,
8CY9
,
8F2J
,
7VNB
,
7Z1C
,
7N9A
,
7KXJ
,
8GZZ
,
7THK
,
7R4Q
,
8EPQ
,
7VQ0
,
8F0G
,
7MJI
,
7DDN
,
7WGX
,
7Y72
,
7W99
,
7L7D
,
7FCE
,
8FDW
,
7MFU
,
7XU0
,
7OD3
,
8DW3
,
7UZ6
,
7WS6
,
8ZC0
,
7L2F
,
7XOB
,
8DT3
,
7XDL
,
7T9J
,
7WG9
,
7TF4
,
7OAP
,
7L09
,
7WCR
,
7X7N
,
7E7D
,
7TAT
,
6XC4
,
7VXK
,
8D0Z
,
7KN5
,
6M17
,
7WB5
,
7Z86
,
7KEB
,
7W94
,
7SXU
,
8XLM
,
7LYQ
,
7SWN
,
8H3E
,
7ND4
,
7WRJ
,
8IF2
,
8CMH
,
7YVK
,
6W41
,
7K8Z
,
7YCL
,
7TOU
,
7EKF
,
7A92
,
7JW0
,
7CZV
,
8I9C
,
7LAB
,
7CWL
,
7V7P
,
7E3C
Interactors (63)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BYF1 ACE2
5
glycosylated-ACE2 [plasma membrane]
(R-HSA-9683480)
ACE2 [endocytic vesicle membrane]
(R-HSA-9698958)
glycosylated-ACE2 [endocytic vesicle membrane]
(R-HSA-9686721)
ACE2 [endoplasmic reticulum lumen]
(R-HSA-9683474)
ACE2(18-805) [plasma membrane]
(R-HSA-2022344)
0.997
242
UniProt:P0DTC2 S
20
S(686-815) [plasma membrane]
(R-COV-9770188)
Spike S2' Fragment [plasma membrane]
(R-COV-9770189)
S1 [plasma membrane]
(R-COV-9769950)
fully glycosylated Spike [plasma membrane]
(R-COV-9733472)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9766369)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
(R-COV-9694638)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
complex N-glycan-PALM-Spike S2 Fragment [plasma membrane]
(R-COV-9769952)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
0.986
60
UniProt:Q9C0B5 ZDHHC5
1
ZDHHC5 [Golgi membrane]
(R-HSA-9766353)
0.864
8
UniProt:Q9H2X3 CLEC4M
1
CLEC4M [plasma membrane]
(R-HSA-1472862)
0.857
12
UniProt:P09958 FURIN
6
FURIN [Golgi membrane]
(R-HSA-157049)
FURIN [extracellular region]
(R-HSA-1181103)
FURIN [plasma membrane]
(R-HSA-2159856)
FURIN [Golgi lumen]
(R-HSA-448351)
FURIN [trans-Golgi network membrane]
(R-HSA-9832627)
FURIN [macropinosome membrane]
(R-HSA-9837714)
0.854
5
UniProt:Q9NNX6 CD209
1
CD209 [plasma membrane]
(R-HSA-2079928)
0.848
11
UniProt:Q7Z5G4 GOLGA7
3
GOLGA7 [Golgi membrane]
(R-HSA-9647777)
GOLGA7 [tertiary granule lumen]
(R-HSA-6800164)
GOLGA7 [extracellular region]
(R-HSA-6800449)
0.817
7
UniProt:P11021 HSPA5
6
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985498)
HSPA5 [nucleoplasm]
(R-HSA-5252042)
HSPA5 [cytosol]
(R-HSA-5252115)
HSPA5 [endoplasmic reticulum membrane]
(R-HSA-351315)
HSPA5 [endoplasmic reticulum lumen]
(R-HSA-387190)
HSPA5 [extracellular region]
(R-HSA-351322)
0.746
8
UniProt:Q8R0I0
1
ACE2(18-805) [plasma membrane]
(R-MMU-2022344)
0.688
4
UniProt:Q8IUN9-2 CLEC10A
0.683
4
UniProt:P35247-PRO_0000017465 SFTPD
0.683
11
UniProt:Q96D42 HAVCR1
1
HAVCR1 [plasma membrane]
(R-HSA-5660386)
0.667
7
UniProt:Q96L92 SNX27
0.664
16
UniProt:P30530 AXL
2
p-Y779,Y821-AXL [plasma membrane]
(R-HSA-5357460)
AXL [plasma membrane]
(R-HSA-197705)
0.655
9
UniProt:P35613 BSG
2
BSG [plasma membrane]
(R-HSA-197673)
BSG [Golgi membrane]
(R-HSA-204478)
0.652
7
IntAct:EBI-26657218 PEPTIDE
0.645
7
ChEBI:17033 BILIVERDIN
0.642
9
UniProt:Q58DD0 ACE2
0.641
3
UniProt:O14786 NRP1
1
NRP1 [plasma membrane]
(R-HSA-3008773)
0.639
9
UniProt:P35579 MYH9
3
MYH9 [cytosol]
(R-HSA-419173)
MYH9(2-1644)-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715280)
MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol]
(R-HSA-9715279)
0.636
8
UniProt:P11226-PRO_0000017401 MBL2
0.632
11
maltose [ChEBI:17306]
2
Mal [cytosol]
(R-ALL-868706)
Mal [extracellular region]
(R-ALL-188986)
0.623
3
ChEBI:28304 HEPARIN
0.623
5
UniProt:P07711 CTSL
8
CTSL(292-333) [endocytic vesicle lumen]
(R-HSA-9686680)
CTSL(114-288) [endocytic vesicle lumen]
(R-HSA-9686686)
CTSL(114-288) [endolysosome lumen]
(R-HSA-1679050)
CTSL(292-333) [endolysosome lumen]
(R-HSA-1679026)
CTSL1(114-288) [early endosome lumen]
(R-HSA-4127474)
CTSL1(114-288) [lysosomal lumen]
(R-HSA-1181225)
CTSL(292-333) [extracellular region]
(R-HSA-449863)
CTSL(114-288) [extracellular region]
(R-HSA-449861)
0.623
3
UniProt:P59665-PRO_0000006773 DEFA1
0.618
3
UniProt:A5CKE2 A5CKE2
0.618
3
UniProt:P31431 SDC4
20
HS(4)-SDC4 [plasma membrane]
(R-HSA-2076670)
HS(6)-SDC4 [plasma membrane]
(R-HSA-2076633)
HS(2)-SDC4 [plasma membrane]
(R-HSA-2076694)
HS(1)-SDC4 [plasma membrane]
(R-HSA-2076653)
HS(3)-SDC4 [plasma membrane]
(R-HSA-2076674)
HS(5)-SDC4 [plasma membrane]
(R-HSA-2076635)
XylS-SDC4 [Golgi lumen]
(R-HSA-2064195)
Gal-Xyl-SDC4 [Golgi lumen]
(R-HSA-2064249)
SDC4 [Golgi lumen]
(R-HSA-2054111)
Gal-Gal-Xyl-SDC4 [Golgi lumen]
(R-HSA-2064100)
GlcA-Gal-Gal-Xyl-SDC4 [Golgi lumen]
(R-HSA-2064067)
HS(3)-SDC4 [Golgi lumen]
(R-HSA-2076418)
HS(4)-SDC4 [Golgi lumen]
(R-HSA-2076407)
HS(2)-SDC4 [Golgi lumen]
(R-HSA-2076411)
HS(1)-SDC4 [Golgi lumen]
(R-HSA-2076434)
Heparan(4)-SDC4 [Golgi lumen]
(R-HSA-2076613)
Heparan(3)-SDC4 [Golgi lumen]
(R-HSA-2076460)
Heparan(2)-SDC4 [Golgi lumen]
(R-HSA-2076446)
Heparan(1)-SDC4 [Golgi lumen]
(R-HSA-2076394)
Heparan-SDC4 [Golgi lumen]
(R-HSA-2076374)
0.599
17
hemin [ChEBI:50385]
1
hemin [cytosol]
(R-ALL-421489)
0.59
2
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.59
2
IntAct:EBI-27090397 RC-101
0.558
2
N-acetylneuraminic acid [ChEBI:17012]
1
Neu5Ac [Golgi lumen]
(R-ALL-975925)
0.558
2
UniProt:Q07021-PRO_0000018590 C1QBP
0.558
2
UniProt:Q61830 Mrc1
4
Mrc1 [plasma membrane]
(R-MMU-1236776)
Mrc1 [plasma membrane]
(R-MMU-1216515)
Mrc1 [clathrin-coated endocytic vesicle membrane]
(R-MMU-1236818)
Mrc1 [early endosome membrane]
(R-MMU-1236785)
0.558
2
lipopolysaccharide [ChEBI:16412]
5
LPS [endocytic vesicle lumen]
(R-ALL-2239413)
LPS [peptidoglycan-based cell wall]
(R-ALL-6803081)
LPS [endosome lumen]
(R-ALL-2201311)
LPS [plasma membrane]
(R-ALL-433850)
LPS [extracellular region]
(R-ALL-166005)
0.558
3
cholesterol [ChEBI:16113]
20
CHOL [lipid droplet]
(R-ALL-163586)
CHOL [early endosome]
(R-ALL-2429660)
CHOL [mitochondrial matrix]
(R-ALL-193840)
CHOL [cornified envelope]
(R-ALL-8847704)
cholesterol [mitochondrial intermembrane space]
(R-ALL-196084)
CHOL [mitochondrial outer membrane]
(R-ALL-8951853)
CHOL [mitochondrial inner membrane]
(R-ALL-193156)
CHOL [lysosomal membrane]
(R-ALL-8876478)
cholesterol [endosome lumen]
(R-ALL-171083)
cholesterol [endosome membrane]
(R-ALL-171135)
cholesterol [clathrin-coated endocytic vesicle membrane]
(R-ALL-171069)
CHOL [endoplasmic reticulum lumen]
(R-ALL-174672)
CHOL [smooth endoplasmic reticulum]
(R-ALL-8866305)
CHOL [transport vesicle membrane]
(R-ALL-216762)
CHOL [lysosomal lumen]
(R-ALL-8848047)
CHOL [cytosol]
(R-ALL-176478)
cholesterol [endocytic vesicle lumen]
(R-ALL-2239405)
CHOL [plasma membrane]
(R-ALL-171095)
CHOL [endoplasmic reticulum membrane]
(R-ALL-193384)
CHOL [extracellular region]
(R-ALL-171149)
0.558
5
UniProt:P35247 SFTPD
3
SFTPD [endoplasmic reticulum membrane]
(R-HSA-5685278)
SFTPD [clathrin-coated endocytic vesicle]
(R-HSA-5686343)
SFTPD [extracellular region]
(R-HSA-391099)
0.544
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.537
4
UniProt:P01130 LDLR
4
LDLR [plasma membrane]
(R-HSA-171053)
LDLR [clathrin-coated endocytic vesicle membrane]
(R-HSA-171105)
LDLR [endosome membrane]
(R-HSA-171127)
LDLR [endolysosome membrane]
(R-HSA-6784818)
0.537
4
UniProt:P60660 MYL6
2
p-S20-MYL6 [cytosol]
(R-HSA-445778)
MYL6 [cytosol]
(R-HSA-419186)
0.527
2
UniProt:Q9ULV4 COR1C
0.527
2
UniProt:Q9NYL9 TMOD3
1
TMOD3 [cytosol]
(R-HSA-217354)
0.527
2
IntAct:EBI-26657222 PEPTIDE
0.525
2
IntAct:EBI-26657225 PEPTIDE
0.525
2
IntAct:EBI-26997889 ACE2
0.524
2
UniProt:A0A1S3APE5 A0A1S3APE5
0.524
2
UniProt:P08670 VIM
11
Vimentin [lysosomal lumen]
(R-HSA-9659977)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [late endosome lumen]
(R-HSA-9660019)
VIM [cytosol]
(R-HSA-201600)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(2-85) [cytosol]
(R-HSA-350264)
0.524
4
UniProt:Q5EGZ1
1
ACE2(18-805) [plasma membrane]
(R-RNO-2022344)
0.524
2
UniProt:E2DHI3 E2DHI3
0.524
2
UniProt:Q14416 GRM2
1
GRM2 [plasma membrane]
(R-HSA-420468)
0.524
4
linoleic acid [ChEBI:17351]
6
LINA [endoplasmic reticulum lumen]
(R-ALL-2046044)
LINA [early endosome]
(R-ALL-879655)
LINA [cytosol]
(R-ALL-1132021)
LINA [extracellular region]
(R-ALL-879520)
LINA [lipid droplet]
(R-ALL-2864095)
LINA [nucleoplasm]
(R-ALL-400158)
0.522
2
UniProt:P35606 COPB2
4
COPB2 [endoplasmic reticulum membrane]
(R-HSA-6810957)
COPB2 [Golgi membrane]
(R-HSA-6808739)
COPB2 [transport vesicle]
(R-HSA-6808741)
COPB2 [cytosol]
(R-HSA-199972)
0.499
3
UniProt:Q9Y5S1 TRPV2
1
TRPV2 [plasma membrane]
(R-HSA-2671909)
0.499
2
UniProt:Q5EA32
1
TRPV2 [plasma membrane]
(R-BTA-2671909)
0.499
3
UniProt:Q5MNZ6 WDR45B
1
WDR45B [cytosol]
(R-HSA-5678303)
0.499
4
UniProt:Q15005 SPCS2
1
SPCS2 [endoplasmic reticulum membrane]
(R-HSA-264996)
0.499
2
UniProt:Q15436 SEC23A
4
SEC23A [endoplasmic reticulum membrane]
(R-HSA-203976)
SEC23A [cytosol]
(R-HSA-203972)
SEC23A [ER to Golgi transport vesicle membrane]
(R-HSA-204024)
p-S738,T744 SEC23A [cytosol]
(R-HSA-5685740)
0.499
20
UniProt:P26038 MSN
4
MSN [cytosol]
(R-HSA-437350)
MSN(2-448)-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711966)
MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol]
(R-HSA-9711971)
p-T558-MSN [cytosol]
(R-HSA-9663005)
0.499
20
UniProt:P0DTD1-PRO_0000449625 REP
0.488
2
UniProt:P0DTD1-PRO_0000449627 REP
0.488
2
UniProt:P0DTD1-PRO_0000449628 REP
0.488
2
UniProt:P15311 EZR
3
p-Y146,Y354-EZR [cytosol]
(R-HSA-374572)
p-T567-EZR [cytosol]
(R-HSA-374559)
EZR [cytosol]
(R-HSA-9020826)
0.483
10
UniProt:P14649 MYL6B
2
p-S20-MYL6B [cytosol]
(R-HSA-445763)
MYL6B [cytosol]
(R-HSA-445776)
0.482
2
UniProt:Q8WXE9 STON2
2
NEDD8-STON2 [cytosol]
(R-HSA-8863733)
STON2 [cytosol]
(R-HSA-8862856)
0.482
2
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