Reactome | RPS15A [nucleoplasm]

RPS15A [nucleoplasm]

Stable Identifier

R-HSA-6791191

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

40S ribosomal protein S15a, RS15A_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P62244 RPS15A

Gene Names

RPS15A, OK/SW-cl.82

Chain

initiator methionine:, chain:2-130

Reference Genes

BioGPS Gene:6210 RPS15A

COSMIC (genes):RPS15A RPS15A

CTD Gene:6210 RPS15A

dbSNP Gene:6210 RPS15A

ENSEMBL:ENSG00000134419 RPS15A

HGNC:10389 RPS15A

KEGG:hsa:6210 RPS15A

Monarch:6210 RPS15A

NCBI Gene:6210 RPS15A

OMIM:603674 RPS15A

UCSC:P62244 RPS15A

Reference Transcript

Other Identifiers

11723251_at

11753656_x_at

11753694_x_at

11757363_x_at

11758880_at

11758881_x_at

16824463

200781_PM_s_at

200781_s_at

229882_PM_at

229882_at

235309_PM_at

235309_at

2409816

2410356

2456846

2456847

2904730

3129993

34316_at

34317_g_at

3650334

3650336

3650337

3683019

3683020

3683021

3683022

3683023

3683024

3683025

3683026

3683027

3683028

3683029

3683030

3683031

3683032

3683034

3683035

3683036

3900471

3900476

44303_at

49788_at

6210

7999827

A_24_P221366

A_33_P3304282

GE78955

GE87302

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0008284

GO:0009615

GO:0016020

GO:0022626

GO:0022627

GO:0032040

GO:0042274

GO:0043226

GO:0045202

GO:0045787

GO:0070062

GO:1990904

HMNXSV003050685

Hs.2953.1.S1_3p_at

Hs.9879.0.S1_3p_at

ILMN_1787949

ILMN_2255310

ILMN_2337241

PH_hs_0028251

PH_hs_0038573

TC16000914.hg

X62691_at

g4506688_3p_a_at

Participates

as a component of

18SE pre-40S particle [nucleoplasm] (Homo sapiens)

This entity regulates

Positively

30S pre-rRNA is nucleolytically processed at site 1 to yield 21S pre-rRNA (Homo sapiens)

Other forms of this molecule

RPS15A [cytosol]

Inferred To

rps2202 [nucleoplasm] (Schizosaccharomyces pombe)

rps-15a [nucleoplasm] (Caenorhabditis elegans)

Rps15a [nucleoplasm] (Mus musculus)

Rps15a [nucleoplasm] (Rattus norvegicus)

rps2201 [nucleoplasm] (Schizosaccharomyces pombe)

RPS15A [nucleoplasm] (Bos taurus)

RPS15A [nucleoplasm] (Canis familiaris)

RPS15A [nucleoplasm] (Gallus gallus)

RPS15A [nucleoplasm] (Plasmodium falciparum)

RPS15A [nucleoplasm] (Sus scrofa)

RPS22A [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of RPS15A [nucleoplasm] (Schizosaccharomyces pombe)

RpS15Aa [nucleoplasm] (Drosophila melanogaster)

rps15a [nucleoplasm] (Danio rerio)

rps15a [nucleoplasm] (Dictyostelium discoideum)

rps15a [nucleoplasm] (Xenopus tropicalis)

Cross References

RefSeq

NP_001025180.1, NP_001010.2

OpenTargets

ENSG00000134419

ENSEMBL

ENST00000563390, ENSP00000458115, ENSP00000318646, ENST00000572008, ENST00000322989, ENSP00000458528, ENST00000565420, ENSP00000457000

HPA

ENSG00000134419-RPS15A

PRO

P62244

Pharos - Targets

P62244

Orphanet

RPS15A

GlyGen

P62244

PDB

6G4W, 6ZMW, 6ZV6, 6ZME, 8XXM, 6ZXE, 7A09, 6YBW, 8JDK, 8G60, 8G5Z, 6ZM7, 6ZOK, 6IP8, 6OLF, 5T2C, 6ZXF, 7WTS, 6ZMT, 8IFE, 6Z6M, 7WTT, 8QOI, 8G6J, 7QP7, 6IP5, 6ZOJ, 6ZVJ, 7WTZ, 6G53, 7XNY, 6OLI, 7MQ9, 6ZP4, 6OLG, 6FEC, 8PPK, 8JDJ, 8Y0W, 6QZP, 5AJ0, 6G5H, 5VYC, 7WTW, 8T4S, 6G4S, 6IP6, 6Y0G, 7QP6, 6ZMO, 6Z6N, 7MQA, 8IFD, 6Y2L, 6Y57, 8XXL, 5A2Q, 8JDM, 8XXN, 6ZLW, 4V6X, 8G5Y, 7R4X, 7MQ8, 6G5I, 6ZXG, 6OLZ, 6G51, 6G18, 6ZMI, 7XNX, 5LKS, 6ZVH, 7WTX, 6ZXD, 7WU0, 6OM0, 6XA1, 8PPL, 8Y0X, 6ZON, 8OZ0, 5FLX, 6OLE, 8G61, 8JDL, 5OA3, 6ZXH, 6ZUO, 8GLP, 7TQL, 7WTU, 6ZN5, 6Z6L, 6OM7, 7WTV, 4UG0, 7K5I

Interactors (19)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.643	3
UniProt:P63244 RACK1	1	GNB2L1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:P28799 GRN	2	GRN [azurophil granule lumen] (R-HSA-6799168) GRN [extracellular region] (R-HSA-6806217)	0.556	3
UniProt:A0A6Q8PF08 A0A6Q8PF08			0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:P06396 GSN	7	GSN [cytosol] (R-HSA-350275) GSN(28-403) [cytosol] (R-HSA-201618) GSN(404-782) [cytosol] (R-HSA-350272) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(200-270) [extracellular region] (R-HSA-976940)	0.556	3
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q15843 NEDD8	8	C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm] (R-HSA-8952504) NEDD8 [nucleoplasm] (R-HSA-8955926) C111-AcM-UBE2M-G76-NEDD8 [cytosol] (R-HSA-4419895) NEDD8 [cytosol] (R-HSA-416969) C237-UBA3-G76-NEDD8 [cytosol] (R-HSA-8951647) NEDD8(1-81) [cytosol] (R-HSA-5690794) NEDD8(77-81) [cytosol] (R-HSA-6782654) C116-AcM-UBE2F-G76-NEDD8 [cytosol] (R-HSA-8951739)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	3
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.527	2
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2

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