Reactome | RPL27A [cytosol]

RPL27A [cytosol]

Stable Identifier

R-HSA-72442

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

60S ribosomal protein L27a, P46776

Locations in the PathwayBrowser

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Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Response of EIF2AK4 (GCN2) to amino acid deficiency (Homo sapiens)
      - EIF2AK4 (GCN2) binds tRNA (Homo sapiens)
        
        EIF2AK4:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
      - EIF2AK4 (GCN2) dimer autophosphorylates (Homo sapiens)
        
        tRNA:EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
      - IMPACT binds GCN1 (Homo sapiens)
        
        GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
        
        IMPACT:GCN1:80S ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
      - p-T899-EIF2AK4 (GCN2) phosphorylates EIF2AS1 (Homo sapiens)
        
        tRNA:p-T899-EIF2AK4:GCN1:80S Ribosome:mRNA [cytosol] (Homo sapiens)
        
        80S Ribosome:mRNA Complex [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - Influenza Infection (Homo sapiens)
      - Influenza Viral RNA Transcription and Replication (Homo sapiens)
        
        Viral mRNA Translation (Homo sapiens)
        
        Synthesis of PB1-F2 (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
        
        Viral Protein Synthesis (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)

Metabolism of RNA (Homo sapiens)

- Nonsense-Mediated Decay (NMD) (Homo sapiens)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
    - SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Homo sapiens)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Homo sapiens)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Homo sapiens)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Homo sapiens)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Homo sapiens)
        
        80S ribosome [cytosol] (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)
- rRNA processing (Homo sapiens)
  - rRNA processing in the nucleus and cytosol (Homo sapiens)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Homo sapiens)
        
        60S ribosomal complex [cytosol] (Homo sapiens)
        
        RPL27A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P46776 RPL27A

Gene Names

RPL27A

Chain

chain:1-148

Reference Genes

BioGPS Gene:6157 RPL27A

COSMIC (genes):RPL27A RPL27A

CTD Gene:6157 RPL27A

dbSNP Gene:6157 RPL27A

ENSEMBL:ENSG00000166441 RPL27A

HGNC:10329 RPL27A

KEGG:hsa:6157 RPL27A

Monarch:6157 RPL27A

NCBI Gene:6157 RPL27A

OMIM:603637 RPL27A

UCSC:P46776 RPL27A

Reference Transcript

RefSeq:NM_000990.4 RPL27A

Other Identifiers

11736810_at

11757154_at

11757155_x_at

11757157_at

11757158_x_at

16721715

16721732

17118780

203034_3p_s_at

203034_PM_s_at

203034_s_at

223707_PM_at

223707_at

2862831

2980367

2980370

2980371

32436_at

3319588

3319589

3319590

3319591

3319592

3319593

3319594

3319595

3319596

3319597

3319598

3319599

3319600

3319601

3319602

3319603

3319604

3319605

3319606

3319607

3319608

3319609

3319610

3319611

3319612

3319614

3319615

3319616

3319617

3319618

3319619

3319620

3319624

3319626

6157

77583_at

7938286

7938291

7938293

7938295

81234_at

8180404

83719_at

A_14_P100322

A_14_P114318

A_21_P0000265

A_21_P0000332

A_23_P203577

A_23_P416305

GE79837

GE84889

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005654

GO:0005737

GO:0005783

GO:0005829

GO:0005840

GO:0006412

GO:0015934

GO:0016020

GO:0022625

GO:0022626

GO:0043226

GO:1990904

HMNXSV003013118

HMNXSV003013268

HMNXSV003025532

HMNXSV003043799

ILMN_1713086

PH_hs_0029866

PH_hs_0037283

PH_hs_0040287

RNA33514|snoRNA_scaRNA_110_131

RNA33519|snoRNA_scaRNA_115_130

TC11000161.hg

TC11003497.hg

TC11003498.hg

U14968_at

g13279118_3p_at

g4506624_3p_a_at

g4506624_3p_x_at

Participates

as a component of

Other forms of this molecule

RPL27A [nucleoplasm]

3OHH39-RPL27A [nucleoplasm]

Inferred To

Homologues of RPL27A [cytosol] (Canis familiaris)

Homologues of RPL27A [cytosol] (Rattus norvegicus)

Homologues of RPL27A [cytosol] (Schizosaccharomyces pombe)

LOC106559080 [cytosol] (Canis familiaris)

RPL27A [cytosol] (Bos taurus)

RPL27A [cytosol] (Canis familiaris)

RPL27A [cytosol] (Gallus gallus)

RPL27A [cytosol] (Plasmodium falciparum)

RPL27A [cytosol] (Sus scrofa)

Rpl27al3 [cytosol] (Rattus norvegicus)

rpl2802 [cytosol] (Schizosaccharomyces pombe)

RpL27A [cytosol] (Drosophila melanogaster)

Rpl27a [cytosol] (Mus musculus)

Rpl27a [cytosol] (Rattus norvegicus)

rpl27a [cytosol] (Dictyostelium discoideum)

rpl2801 [cytosol] (Schizosaccharomyces pombe)

Ghost homologue of RPL27A [cytosol] (Danio rerio)

Ghost homologue of RPL27A [cytosol] (Xenopus tropicalis)

rpl-27a [cytosol] (Caenorhabditis elegans)

RPL28 [cytosol] (Saccharomyces cerevisiae)

Cross References

OpenTargets

ENSG00000166441

ENSEMBL

ENSG00000166441, ENSP00000346015, ENST00000314138

HPA

ENSG00000166441-RPL27A

GeneCards

RPL27A

PRO

P46776

Pharos - Targets

P46776

GlyGen

P46776

PDB

6IP5, 8G6J, 8FKZ, 8FLB, 8FKT, 8XSX, 8FL6, 9G8M, 8QFD, 6Y0G, 6LU8, 8G61, 8IPY, 8FL2, 8JDK, 8K2C, 6Y2L, 8Y0X, 6XA1, 6OLE, 8INK, 8IPX, 8OJ8, 9GMO, 6Z6N, 6IP6, 8IR1, 8FKQ, 8FLA, 7XNY, 5LKS, 8IFE, 8FKV, 4UG0, 8FKW, 8IR3, 8IDY, 8YOP, 8A3D, 8IPD, 8IDT, 6LQM, 8FL4, 8FLC, 8G60, 6OLF, 8JDJ, 6OLI, 6Z6L, 6LSS, 8OHD, 8IFD, 8INE, 8FLD, 8FKR, 8XSZ, 8IE3, 8FL7, 8FKX, 8FKP, 6Y57, 6IP8, 6OLZ, 7QVP, 6ZM7, 8Y0W, 6Y6X, 5AJ0, 8JDM, 8G5Z, 8G5Y, 8OJ0, 6ZMI, 7OW7, 6LSR, 5T2C, 8XSY, 8FLE, 6OM7, 8FKY, 8FKS, 8FKU, 8YOO, 8FL9, 7BHP, 8FLF, 8GLP, 8FL3, 4V6X, 6OLG, 6W6L, 6ZME, 8JDL, 6ZMO, 8INF, 6OM0, 6Z6M, 6QZP, 8QOI, 4BXF, 7F5S, 8OJ5

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.643	3
UniProt:P63244 RACK1	1	RACK1 [cytosol] (R-HSA-5626956)	0.638	3
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.615	3
UniProt:Q86VP6 CAND1	5	CAND1 [cytosol] (R-HSA-5691146) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [nucleoplasm] (R-HSA-8955089)	0.564	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:Q5VTB9 RNF220	1	RNF220 [cytosol] (R-HSA-975978)	0.527	2
UniProt:P82933 MRPS9	1	MRPS9 [mitochondrial inner membrane] (R-HSA-5368194)	0.527	3
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.527	2
UniProt:Q9BYC9 MRPL20	1	MRPL20 [mitochondrial inner membrane] (R-HSA-5368243)	0.527	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.527	2
UniProt:Q92665 MRPS31	1	MRPS31 [mitochondrial inner membrane] (R-HSA-5368198)	0.527	2
UniProt:P13693 TCTP			0.527	2
UniProt:Q99848 EBNA1BP2	1	EBNA1BP2 [nucleoplasm] (R-HSA-8869325)	0.527	2
UniProt:P13984 GTF2F2	1	GTF2F2 [nucleoplasm] (R-HSA-65567)	0.524	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	12
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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