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CAND1 [nucleoplasm]
Stable Identifier
R-HSA-8955089
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Cullin-associated NEDD8-dissociated protein 1, CAND1_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Homo sapiens)
CAND1 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
CAND1 [nucleoplasm] (Homo sapiens)
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)
CAND1 [nucleoplasm] (Homo sapiens)
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
CAND1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86VP6 CAND1
Gene Names
CAND1, KIAA0829, TIP120, TIP120A
Chain
initiator methionine:, chain:2-1230
Reference Genes
BioGPS Gene:55832 CAND1
COSMIC (genes):CAND1 CAND1
CTD Gene:55832 CAND1
dbSNP Gene:55832 CAND1
ENSEMBL:ENSG00000111530 CAND1
HGNC:30688 CAND1
KEGG:hsa:55832 CAND1
Monarch:55832 CAND1
NCBI Gene:55832 CAND1
OMIM:607727 CAND1
UCSC:Q86VP6 CAND1
Reference Transcript
RefSeq:NM_018448.4 CAND1
Other Identifiers
11719937_a_at
11719938_s_at
11719939_a_at
1556318_3p_s_at
1556318_PM_s_at
1556318_s_at
16753712
207483_PM_s_at
207483_s_at
208838_PM_at
208838_at
208839_PM_s_at
208839_s_at
235224_PM_s_at
235224_s_at
239771_PM_at
239771_at
243910_PM_x_at
243910_x_at
32196_at
3420716
3420717
3420718
3420719
3420720
3420721
3420722
3420724
3420727
3420728
3420729
3420734
3420735
3420736
3420737
3420738
3420739
3420740
3420741
3420742
3420744
3420745
3420746
3420747
3420750
3420753
3420754
3420755
3420756
3420757
3420758
3420759
3420760
3420761
3420762
3420764
3420766
3420768
3420770
3420772
3420774
50546_at
55832
59523_at
68781_at
7956910
86969_at
88937_at
A_14_P131977
A_14_P135815
A_23_P25137
A_23_P25141
A_24_P47681
A_32_P150418
A_32_P232237
GE62226
GE82377
GE893252
GO:0000151
GO:0005515
GO:0005576
GO:0005634
GO:0005654
GO:0005737
GO:0005794
GO:0005829
GO:0006355
GO:0010265
GO:0016020
GO:0016567
GO:0017025
GO:0030154
GO:0031461
GO:0034774
GO:0043086
GO:0043226
GO:0045893
GO:0045899
GO:0065003
GO:0070062
GO:1904813
HMNXSV003013627
HMNXSV003015307
Hs.128521.0.S1_3p_at
Hs.200073.0.A1_3p_s_at
Hs.209521.0.A1_3p_at
Hs2.397035.1.A1_3p_at
Hs2.397035.1.A1_3p_s_at
ILMN_1744647
PH_hs_0026787
TC12000595.hg
TC12002426.hg
g12053130_3p_a_at
g8924259_3p_s_at
Participates
as an input of
CAND1 binds CRL4 E3 ubiquitin ligase in the nucleus (Homo sapiens)
as an output of
COMMDs displace CAND1 from CRL4 E3 ubiquitin ligase complex (Homo sapiens)
as a component of
CRL4 E3 ubiquitin ligase:CAND1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
CAND1 [cytosol]
CAND1 [secretory granule lumen]
CAND1 [extracellular region]
CAND1 [ficolin-1-rich granule lumen]
Inferred To
knd1 [nucleoplasm]
(Schizosaccharomyces pombe)
CAND1 [nucleoplasm]
(Bos taurus)
CAND1 [nucleoplasm]
(Canis familiaris)
CAND1 [nucleoplasm]
(Gallus gallus)
CAND1 [nucleoplasm]
(Schizosaccharomyces pombe)
CAND1 [nucleoplasm]
(Sus scrofa)
cand1 [nucleoplasm]
(Danio rerio)
cand1 [nucleoplasm]
(Dictyostelium discoideum)
cand1 [nucleoplasm]
(Xenopus tropicalis)
Cand1 [nucleoplasm]
(Drosophila melanogaster)
Cand1 [nucleoplasm]
(Mus musculus)
Cand1 [nucleoplasm]
(Rattus norvegicus)
Ghost homologue of CAND1 [nucleoplasm]
(Plasmodium falciparum)
cand-1 [nucleoplasm]
(Caenorhabditis elegans)
Homologues of CAND1 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_060918.2
OpenTargets
ENSG00000111530
ENSEMBL
ENST00000545606
,
ENSP00000442318
HPA
ENSG00000111530-CAND1
PRO
Q86VP6
Pharos - Targets
Q86VP6
GlyGen
Q86VP6
PDB
7Z8R
,
7Z8T
,
8OR0
,
8OR2
,
4A0C
,
7Z8V
,
8OR3
,
7ZBW
,
7ZBZ
,
8OR4
,
1U6G
,
8CDK
,
8H3Q
,
8CDJ
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13616 CUL1
3
CUL1 [cytosol]
(R-HSA-174230)
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
0.956
33
UniProt:Q13620 CUL4B
2
CUL4B [nucleoplasm]
(R-HSA-975973)
G76-NEDD8-K859-CUL4B [nucleoplasm]
(R-HSA-8952522)
0.793
13
UniProt:Q13618 CUL3
3
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
CUL3 [nucleoplasm]
(R-HSA-5635033)
CUL3 [cytosol]
(R-HSA-975979)
0.748
8
UniProt:Q13619 CUL4A
2
CUL4A [nucleoplasm]
(R-HSA-976006)
G76-NEDD8-K705-CUL4A [nucleoplasm]
(R-HSA-8952514)
0.723
6
UniProt:P62877 RBX1
2
RBX1 [cytosol]
(R-HSA-180582)
RBX1 [nucleoplasm]
(R-HSA-1234142)
0.708
10
UniProt:Q13617 CUL2
3
CUL2 [cytosol]
(R-HSA-416982)
CUL2 [nucleoplasm]
(R-HSA-1234126)
G76-NEDD8-K689-CUL2 [cytosol]
(R-HSA-8952511)
0.641
3
UniProt:P46776 RPL27A
3
RPL27A [cytosol]
(R-HSA-72442)
RPL27A [nucleoplasm]
(R-HSA-9630984)
3OHH39-RPL27A [nucleoplasm]
(R-HSA-9630970)
0.564
2
UniProt:Q14627 IL13RA2
1
IL13RA2 [extracellular region]
(R-HSA-449666)
0.527
2
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.527
9
UniProt:Q92804 TAF15
1
TAF15 [nucleoplasm]
(R-HSA-9020680)
0.483
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
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