Reactome | TBC1D15 [cytosol]

TBC1D15 [cytosol]

Stable Identifier

R-HSA-8854150

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TBC1 domain family member 15, TBC15_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8TC07 TBC1D15

Gene Names

TBC1D15

Chain

initiator methionine:, chain:2-691

Reference Genes

BioGPS Gene:64786 TBC1D15

COSMIC (genes):TBC1D15 TBC1D15

CTD Gene:64786 TBC1D15

dbSNP Gene:64786 TBC1D15

ENSEMBL:ENSG00000121749 TBC1D15

HGNC:25694 TBC1D15

Monarch:64786 TBC1D15

NCBI Gene:64786 TBC1D15

OMIM:612662 TBC1D15

UCSC:Q8TC07 TBC1D15

Reference Transcript

Other Identifiers

11727377_a_at

11727378_at

11757471_s_at

16754208

218268_PM_at

218268_at

230072_PM_at

230072_at

3422327

3422328

3422330

3422333

3422334

3422336

3422338

3422339

3422340

3422341

3422344

3422345

3422346

3422347

3422348

3422349

3422350

3422351

3422354

3422355

3422356

3422357

3422359

3422360

3422361

3422363

3422364

3422367

3422368

3422370

3422371

3422373

3422374

3422375

3422383

3422384

3422385

46955_at

64420_at

64786

70482_at

76716_at

7957186

82931_at

A_14_P137092

A_23_P139558

GE56826

GO:0005096

GO:0005515

GO:0005576

GO:0005737

GO:0043087

GO:0098772

HMNXSV003022168

Hs.146220.0.A1_3p_at

ILMN_1803941

PH_hs_0039971

TC12000628.hg

TC12002446.hg

g12232450_3p_at

This entity regulates

Positively

TBC1D15 accelerates GTP hydrolysis by RAB7 (Homo sapiens)

Inferred To

GYP7 [cytosol] (Saccharomyces cerevisiae)

Tbc1d15 [cytosol] (Mus musculus)

Tbc1d15 [cytosol] (Rattus norvegicus)

tbc-14 [cytosol] (Caenorhabditis elegans)

gyp7 [cytosol] (Schizosaccharomyces pombe)

tbc1d15 [cytosol] (Xenopus tropicalis)

TBC1D15 [cytosol] (Bos taurus)

TBC1D15 [cytosol] (Canis familiaris)

TBC1D15 [cytosol] (Dictyostelium discoideum)

TBC1D15 [cytosol] (Gallus gallus)

TBC1D15 [cytosol] (Sus scrofa)

Tbc1d15-17 [cytosol] (Drosophila melanogaster)

Cross References

ENSEMBL

ENST00000550746, ENSP00000448182, ENSP00000318262, ENST00000485960, ENST00000319106, ENSP00000420678

OpenTargets

ENSG00000121749

HPA

ENSG00000121749-TBC1D15

PRO

Q8TC07

Pharos - Targets

Q8TC07

GlyGen

Q8TC07

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.805	9
UniProt:Q96MT8 CEP63	1	CEP63 [cytosol] (R-HSA-380267)	0.739	5
UniProt:O95166 GABARAP	3	GABARAP [cytosol] (R-HSA-975521) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [autophagosome membrane] (R-HSA-5683634)	0.591	5
UniProt:Q86VP1 TAX1BP1	1	TAX1BP1 [cytosol] (R-HSA-937346)	0.556	3
UniProt:Q96MT8-3 CEP63			0.556	3
UniProt:Q9P1Z2 CACO1			0.556	3
UniProt:P60520 GABARAPL2	3	GABARAPL2 [cytosol] (R-HSA-5671758) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [autophagosome membrane] (R-HSA-5683633)	0.544	2
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [cytosol] (R-HSA-5671757) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [autophagosome membrane] (R-HSA-5683637)	0.544	2
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [cytosol] (R-HSA-5205651) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [autophagosome membrane] (R-HSA-5683641)	0.544	2
UniProt:Q8NBM4 UBAC2			0.527	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2

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