Reactome | GABARAP [cytosol]

GABARAP [cytosol]

Stable Identifier

R-HSA-975521

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Gamma-aminobutyric acid receptor-associated protein, GBRAP_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O95166 GABARAP

Gene Names

GABARAP, FLC3B, HT004

Chain

chain:1-116, propeptide:-

Reference Genes

BioGPS Gene:11337 GABARAP

COSMIC (genes):GABARAP GABARAP

CTD Gene:11337 GABARAP

dbSNP Gene:11337 GABARAP

ENSEMBL:ENSG00000170296 GABARAP

ENSEMBL_homo_sapiens_GENE:ENSG00000170296.10 GABARAP

HGNC:4067 GABARAP

KEGG Gene (Homo sapiens):11337 GABARAP

Monarch:11337 GABARAP

NCBI Gene:11337 GABARAP

OMIM:605125 GABARAP

Reference Transcript

RefSeq:NM_007278.1 GABARAP

Other Identifiers

11337

11715479_a_at

11715480_x_at

16840579

200645_PM_at

200645_at

2376589

2376592

37298_at

3743482

3743483

3743484

3743485

3743487

3743488

3743489

3743491

3743492

3743493

3743496

3743497

3743498

8012110

A_23_P27075

GE58449

GO:0000045

GO:0000139

GO:0000226

GO:0000421

GO:0005515

GO:0005737

GO:0005764

GO:0005773

GO:0005776

GO:0005783

GO:0005790

GO:0005794

GO:0005829

GO:0005856

GO:0005874

GO:0005875

GO:0005886

GO:0005929

GO:0005930

GO:0006605

GO:0006886

GO:0006914

GO:0006915

GO:0006995

GO:0007010

GO:0007268

GO:0008017

GO:0008092

GO:0008289

GO:0008429

GO:0008625

GO:0012501

GO:0012505

GO:0015031

GO:0015629

GO:0016020

GO:0016236

GO:0023052

GO:0030163

GO:0031410

GO:0031625

GO:0031982

GO:0032436

GO:0035020

GO:0036211

GO:0043226

GO:0045202

GO:0048487

GO:0050811

GO:0097225

GO:1902524

HMNXSV003026035

ILMN_2050109

PH_hs_0018576

PH_hs_0036172

TC17001081.hg

g6005763_3p_at

g6005763_3p_x_at

Participates

as a member of

LC3 family [cytosol] (Homo sapiens)

Other forms of this molecule

GABARAP [autophagosome membrane]

GABARAP(1-117) [cytosol]

Inferred To

atg8 [cytosol] (Dictyostelium discoideum)

atg8 [cytosol] (Schizosaccharomyces pombe)

lgg-1 [cytosol] (Caenorhabditis elegans)

ATG8 [cytosol] (Saccharomyces cerevisiae)

Atg8a [cytosol] (Drosophila melanogaster)

gabarapa [cytosol] (Danio rerio)

wu:fj43a09 [cytosol] (Danio rerio)

Gabarap [cytosol] (Mus musculus)

Gabarap [cytosol] (Rattus norvegicus)

Homologues of GABARAP [cytosol] (Danio rerio)

Homologues of GABARAP [cytosol] (Dictyostelium discoideum)

GABARAP [cytosol] (Bos taurus)

GABARAP [cytosol] (Canis familiaris)

GABARAP [cytosol] (Dictyostelium discoideum)

GABARAP [cytosol] (Plasmodium falciparum)

GABARAP [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_009209.1

OpenTargets

ENSG00000170296

HPA

ENSG00000170296-GABARAP

GeneCards

O95166

Ensembl

ENSP00000306866, ENST00000302386, ENSG00000170296

PRO

O95166

Pharos - Targets

O95166

HMDB Protein

HMDBP10819

PDB

7LSW, 7BRQ, 7ZL7, 6HYN, 3DOW, 6HYO, 6HB9, 6HYM, 6HOK, 1KOT, 7ZKR, 3D32, 7EA7, 7BV4, 6HOJ, 6HYL, 6HOH, 5DPS, 8AFI, 7VED, 6HOG, 7BRU, 6YOP, 7AA8, 1GNU, 4XC2, 7VEC, 1KM7, 7LT6, 7BRT, 3WIM, 8T2N, 8T2M, 1KLV, 7YO9

Interactors (16)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.948	17
UniProt:Q14596 NBR1	2	NBR1 [peroxisomal membrane] (R-HSA-9665177) NBR1 [cytosol] (R-HSA-9665180)	0.775	6
UniProt:P27797 CALR	6	CALR [lumenal side of endoplasmic reticulum membrane] (R-HSA-985502) CALR [extracellular region] (R-HSA-2197641) CALR [endocytic vesicle lumen] (R-HSA-2239448) CALR [endoplasmic reticulum lumen] (R-HSA-195905) CALR [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-8863866) CALR [phagocytic vesicle membrane] (R-HSA-1236879)	0.71	4
UniProt:Q9NT62 ATG3	8	ATG3 [cytosol] (R-HSA-5671860) CysO264-ATG3-MAP1LC3A [cytosol] (R-HSA-9819371) CysO264-ATG3-GABARAP [cytosol] (R-HSA-9819379) CysO264-ATG3-GABARAPL3 [cytosol] (R-HSA-5683569) CysO264-ATG3-MAP1LC3B [cytosol] (R-HSA-9819365) CysO264-ATG3-GABARAPL1 [cytosol] (R-HSA-9819381) CysO264-ATG3-MAP1LC3C [cytosol] (R-HSA-9819377) CysO264-ATG3-GABARAPL2 [cytosol] (R-HSA-9819376)	0.667	5
UniProt:O75385 ULK1	7	ULK1 [recycling endosome] (R-HSA-8854761) p-S758-ULK1 [cytosol] (R-HSA-5672131) p-S317,467,556,638,T575-ULK1 [cytosol] (R-HSA-5673747) p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-HSA-5675858) p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-HSA-8948047) ULK1 [cytosol] (R-HSA-1632847) ULK1 [mitochondrial outer membrane] (R-HSA-8948145)	0.609	2
UniProt:O00410 IPO5	1	IPO5 [nucleoplasm] (R-HSA-192675)	0.591	6
UniProt:Q8TC07 TBC1D15	1	TBC1D15 [cytosol] (R-HSA-8854150)	0.591	5
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.59	5
UniProt:Q96A56 TP53INP1	1	TP53INP1 [nucleoplasm] (R-HSA-3215226)	0.556	3
UniProt:Q9H1Y0 ATG5	3	ATG5 [phagocytic vesicle membrane] (R-HSA-5205636) GlyK130-ATG5 [cytosol] (R-HSA-5683582) ATG5 [cytosol] (R-HSA-936010)	0.544	2
UniProt:Q13188 STK3	4	p-T180-STK3(1-322) [cytosol] (R-HSA-2028696) STK3(323-491) [cytosol] (R-HSA-2028684) STK3(1-491) [cytosol] (R-HSA-2028280) p-T180-STK3(1-491) [cytosol] (R-HSA-2028274)	0.544	2
UniProt:Q13043 STK4	4	STK4(1-487) [cytosol] (R-HSA-201627) p-T183-STK4(1-326) [cytosol] (R-HSA-2028682) p-T183-STK4(1-487) [cytosol] (R-HSA-2028258) STK4(327-487) [cytosol] (R-HSA-2028668)	0.544	2
UniProt:Q9Z2F7	1	Bnip3l [mitochondrial outer membrane] (R-MMU-6798001)	0.544	2
UniProt:Q3MII6 TBC1D25	1	TBC1D25 [autophagosome] (R-HSA-8854607)	0.527	2
UniProt:Q92636 NSMAF	1	NSMAF [cytosol] (R-HSA-5626992)	0.525	2
UniProt:P46934 NEDD4	1	NEDD4 [cytosol] (R-HSA-975992)	0.525	6

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