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RNF7 (RBX2) [cytosol]
Stable Identifier
R-HSA-8863132
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
RNF7, RING-box protein 2, RBX2_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
Inactivation of CSF3 (G-CSF) signaling (Homo sapiens)
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
RNF7 (RBX2) [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBF6 RNF7
Gene Names
RNF7, RBX2, ROC2, SAG
Chain
initiator methionine:, chain:2-113
Reference Genes
BioGPS Gene:9616 RNF7
COSMIC (genes):RNF7 RNF7
CTD Gene:9616 RNF7
dbSNP Gene:9616 RNF7
ENSEMBL:ENSG00000114125 RNF7
ENSEMBL_homo_sapiens_GENE:ENSG00000114125.14 RNF7
HGNC:10070 RNF7
KEGG Gene (Homo sapiens):9616 RNF7
Monarch:9616 RNF7
NCBI Gene:9616 RNF7
OMIM:603863 RNF7
UCSC:Q9UBF6 RNF7
Reference Transcript
RefSeq:NM_014245.4 RNF7
RefSeq:NM_183237.2 RNF7
RefSeq:NM_001201370.1 RNF7
Other Identifiers
11716755_at
11716756_at
11751858_a_at
11762347_at
16946439
218286_PM_s_at
218286_s_at
224394_PM_at
224394_at
224395_PM_s_at
224395_s_at
224439_PM_x_at
224439_x_at
2645691
2645692
2645693
2645696
2645697
2645699
2645700
2645701
2645702
2645703
2645704
2645705
2645707
2645708
2645709
78648_at
8083119
91720_at
9616
A_23_P109768
A_33_P3252915
GE62345
GO:0003824
GO:0005507
GO:0005515
GO:0005634
GO:0005654
GO:0005680
GO:0005737
GO:0005829
GO:0006511
GO:0008270
GO:0016567
GO:0016740
GO:0019788
GO:0030163
GO:0031145
GO:0031466
GO:0036211
GO:0043226
GO:0043687
GO:0045116
GO:0046872
GO:0051775
GO:0061630
GO:0061663
GO:0097602
GO:0140096
HMNXSV003001410
ILMN_1711862
ILMN_1731123
ILMN_2389957
PH_hs_0026901
TC03000764.hg
TC03002569.hg
g13649605_3p_at
g13649605_3p_s_at
Participates
as an output of
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)
as a component of
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 [endocytic vesicle membrane] (Homo sapiens)
CRL5 E3 ubiquitin ligase [cytosol] (Homo sapiens)
NEDD8-CRL5 E3 ligase [cytosol] (Homo sapiens)
RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Homo sapiens)
as an input of
SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)
Inferred To
RNF7 (RBX2) [cytosol]
(Dictyostelium discoideum)
RNF7 (RBX2) [cytosol]
(Gallus gallus)
RNF7 (RBX2) [cytosol]
(Saccharomyces cerevisiae)
RNF7 (RBX2) [cytosol]
(Schizosaccharomyces pombe)
Roc2 [cytosol]
(Drosophila melanogaster)
rnf7 [cytosol]
(Danio rerio)
rnf7 [cytosol]
(Xenopus tropicalis)
Ghost homologue of RNF7 (RBX2) [cytosol]
(Sus scrofa)
Rnf7 [cytosol]
(Mus musculus)
Rnf7 [cytosol]
(Rattus norvegicus)
RNF7 [cytosol]
(Bos taurus)
RNF7 [cytosol]
(Canis familiaris)
rbx-2 [cytosol]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_055060.1
,
NP_899060.1
,
NP_001188299.1
OpenTargets
ENSG00000114125
IntEnz
2.3.2.32
HPA
ENSG00000114125-RNF7
GeneCards
Q9UBF6
Ensembl
ENST00000477012
,
ENST00000480908
,
ENST00000273480
,
ENST00000393000
,
ENSP00000376725
,
ENSP00000419084
,
ENSP00000419339
,
ENSP00000273480
,
ENSG00000114125
PRO
Q9UBF6
Pharos - Targets
Q9UBF6
PDB
7ONI
,
2ECL
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q93034 CUL5
2
CUL5 [cytosol]
(R-HSA-180528)
G76-NEDD8-K724-CUL5 [cytosol]
(R-HSA-8952014)
0.871
11
UniProt:Q96S21 RAB40C
2
GGC-RAB40C [cytosol]
(R-HSA-8874025)
RAB40C [cytosol]
(R-HSA-8873693)
0.642
5
UniProt:Q9Y6K9 IKBKG
12
IKBKG D406V [cytosol]
(R-HSA-5262943)
IKBKG L153R [cytosol]
(R-HSA-5262879)
IKBKG E391* [cytosol]
(R-HSA-5262924)
IKBKG C417R [cytosol]
(R-HSA-5262858)
IKBKG R173G [cytosol]
(R-HSA-5262966)
IKBKG R175P [cytosol]
(R-HSA-5262916)
IKBKG *420Wext*447 [cytosol]
(R-HSA-5262978)
monoSUMO1-K277,K309-IKBKG [nucleoplasm]
(R-HSA-4755449)
IKBKG [nucleoplasm]
(R-HSA-4755413)
K63polyUb-IKBKG [cytosol]
(R-HSA-202530)
Ub-285-IKBKG [cytosol]
(R-HSA-741397)
IKBKG [cytosol]
(R-HSA-168108)
0.581
3
UniProt:Q9H672 ASB7
1
ASB7 [cytosol]
(R-HSA-975425)
0.564
4
UniProt:Q9NWX5 ASB6
1
ASB6 [cytosol]
(R-HSA-975412)
0.564
4
UniProt:Q9Y576 ASB1
1
ASB1 [cytosol]
(R-HSA-975428)
0.564
4
UniProt:P12504 VIF
0.558
4
UniProt:Q99619 SPSB2
1
SPSB2 [cytosol]
(R-HSA-976048)
0.527
3
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.508
3
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