Reactome | RNF7 (RBX2) [cytosol]

RNF7 (RBX2) [cytosol]

Stable Identifier

R-HSA-8863132

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

RNF7, RING-box protein 2, RBX2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UBF6 RNF7

Gene Names

RNF7, RBX2, ROC2, SAG

Chain

initiator methionine:1, chain:2-113

Reference Genes

BioGPS Gene:9616 RNF7

COSMIC (genes):RNF7 RNF7

COSMIC (genes):SAG SAG

CTD Gene:9616 RNF7

dbSNP Gene:9616 RNF7

ENSEMBL:ENSG00000114125 RNF7

HGNC:10070 RNF7

KEGG:hsa:9616 RNF7

Monarch:9616 RNF7

NCBI Entrez Gene:9616 RNF7

OMIM:603863 RNF7

UCSC:Q9UBF6 RNF7

Reference Transcript

Other Identifiers

11716755_at

11716756_at

11751858_a_at

11762347_at

16946439

218286_PM_s_at

218286_s_at

224394_PM_at

224394_at

224395_PM_s_at

224395_s_at

224439_PM_x_at

224439_x_at

2645691

2645692

2645693

2645696

2645697

2645698

2645699

2645700

2645701

2645702

2645703

2645704

2645705

2645707

2645708

2645709

78648_at

8083119

91720_at

9616

A_14_P130215

A_23_P109768

A_33_P3252915

GE62345

GO:0001837

GO:0002376

GO:0003824

GO:0005507

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006511

GO:0006575

GO:0008270

GO:0010498

GO:0016567

GO:0016740

GO:0019788

GO:0021819

GO:0030154

GO:0030163

GO:0030335

GO:0030968

GO:0031146

GO:0031466

GO:0035556

GO:0038026

GO:0038162

GO:0043161

GO:0043687

GO:0045087

GO:0045116

GO:0046314

GO:0046872

GO:0051607

GO:0051775

GO:0051894

GO:0051895

GO:0060396

GO:0060397

GO:0060400

GO:0061630

GO:0061663

GO:0070979

GO:0097602

GO:0098542

GO:0120184

GO:0140096

GO:0140896

GO:2001222

HMNXSV003001410

ILMN_1711862

ILMN_1731123

ILMN_2389957

PH_hs_0026901

TC03000764.hg

TC03002569.hg

g13649605_3p_at

g13649605_3p_s_at

Participates

as an output of

SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7 (Homo sapiens)

as a component of

as an input of

SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2 binds CUL5, ELOB, ELOC, RNF7 (Homo sapiens)

Inferred To

RNF7 (RBX2) [cytosol] (Dictyostelium discoideum)

RNF7 (RBX2) [cytosol] (Gallus gallus)

RNF7 (RBX2) [cytosol] (Saccharomyces cerevisiae)

RNF7 (RBX2) [cytosol] (Schizosaccharomyces pombe)

Roc2 [cytosol] (Drosophila melanogaster)

rnf7 [cytosol] (Danio rerio)

rnf7 [cytosol] (Xenopus tropicalis)

Ghost homologue of RNF7 (RBX2) [cytosol] (Sus scrofa)

Rnf7 [cytosol] (Mus musculus)

Rnf7 [cytosol] (Rattus norvegicus)

RNF7 [cytosol] (Bos taurus)

RNF7 [cytosol] (Canis familiaris)

rbx-2 [cytosol] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001188299.1, NP_899060.1, NP_055060.1

OpenTargets

ENSG00000114125

ENSEMBL

ENST00000477012, ENSP00000273480, ENSG00000114125, ENSP00000376725, ENST00000393000, ENSP00000419339, ENSP00000419084, ENST00000480908, ENST00000273480

IntEnz

2.3.2.32

HPA

ENSG00000114125-RNF7

GeneCards

RNF7

PRO

Q9UBF6

Pharos - Targets

Q9UBF6

GlyGen

Q9UBF6

PDB

7ONI, 2ECL

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q93034 CUL5	2	CUL5 [cytosol] (R-HSA-180528) G76-NEDD8-K724-CUL5 [cytosol] (R-HSA-8952014)	0.905	12
UniProt:Q96S21 RAB40C	2	GGC-RAB40C [cytosol] (R-HSA-8874025) RAB40C [cytosol] (R-HSA-8873693)	0.723	6
UniProt:Q9Y576 ASB1	1	ASB1 [cytosol] (R-HSA-975428)	0.669	5
UniProt:Q9NWX5 ASB6	1	ASB6 [cytosol] (R-HSA-975412)	0.669	5
UniProt:Q9H672 ASB7	1	ASB7 [cytosol] (R-HSA-975425)	0.669	5
UniProt:Q99619 SPSB2	1	SPSB2 [cytosol] (R-HSA-976048)	0.643	4
UniProt:Q9Y6K9 IKBKG	12	IKBKG [cytosol] (R-HSA-168108) Ub-285-IKBKG [cytosol] (R-HSA-741397) K63polyUb-IKBKG [cytosol] (R-HSA-202530) IKBKG [nucleoplasm] (R-HSA-4755413) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG D406V [cytosol] (R-HSA-5262943)	0.581	3
UniProt:P12504 VIF			0.558	4
UniProt:Q8WXH5 SOCS4	1	SOCS4 [cytosol] (R-HSA-8936109)	0.527	4
UniProt:Q96MG8 PCMD1			0.527	3
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.527	4
UniProt:Q9HBH1 DEFM			0.527	3
UniProt:Q15345 LRRC41	1	LRRC41 [cytosol] (R-HSA-976015)	0.527	4
UniProt:Q86VP6 CAND1	5	CAND1 [cytosol] (R-HSA-5691146) CAND1 [secretory granule lumen] (R-HSA-6801390) CAND1 [extracellular region] (R-HSA-6806498) CAND1 [ficolin-1-rich granule lumen] (R-HSA-6801399) CAND1 [nucleoplasm] (R-HSA-8955089)	0.527	2
UniProt:Q6PJ21 SPSB3	1	SPSB3 [cytosol] (R-HSA-400242)	0.527	4
UniProt:Q9NV79 PCMD2			0.527	3
UniProt:Q9H9Q2 COPS7B	2	COPS7B [nucleoplasm] (R-HSA-5697023) COPS7B [cytosol] (R-HSA-416966)	0.527	2
UniProt:Q9NRJ4 TULP4	1	TULP4 [cytosol] (R-HSA-8863142)	0.527	3
UniProt:Q8WUH2 TGFA1			0.527	3
UniProt:Q9H270 VPS11	1	VPS11 [endosome membrane] (R-HSA-2197802)	0.527	3
UniProt:O14512 SOCS7			0.527	4
UniProt:Q8IWT3 CUL9	2	G76-NEDD8-K1881-CUL9 [cytosol] (R-HSA-8955921) CUL9 [cytosol] (R-HSA-8855018)	0.527	4
UniProt:O75159 SOCS5	1	SOCS5 [cytosol] (R-HSA-6788342)	0.527	4
UniProt:Q9Y6I7 WSB1	1	WSB1 [cytosol] (R-HSA-976016)	0.527	4
UniProt:Q9NYS7 WSB2	1	WSB2 [cytosol] (R-HSA-8863349)	0.527	4
UniProt:P12004 PCNA	5	PCNA [nucleoplasm] (R-HSA-68439) MonoUb-K164-PCNA [nucleoplasm] (R-HSA-5651986) ISG-K164,ISG-K168-PCNA [nucleoplasm] (R-HSA-5653768) K63polyUb-K164-PCNA [nucleoplasm] (R-HSA-8943000) monoSUMO1-K164,K254,K-PCNA [nucleoplasm] (R-HSA-4615861)	0.508	3