Reactome | ATP6V1A [cytosol]

ATP6V1A [cytosol]

Stable Identifier

R-HSA-912602

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Cellular responses to stimuli (Homo sapiens)

- Cellular responses to stress (Homo sapiens)
  - Cellular response to starvation (Homo sapiens)
    - Amino acids regulate mTORC1 (Homo sapiens)
      - RRAGA,B exchanges GDP for GTP (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
      - RRAGA,B hydrolyzes GTP (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
      - RRAGC,D exchanges GTP for GDP (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
      - RRAGC,D hydrolyzes GTP (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
      - mTORC1 binds RHEB:GTP (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1:RHEB:GTP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP binds mTORC1 (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:mTORC1 [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
      - v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arginine dissociates yielding v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP and SLC38A9:Arginine (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GTP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
      - v-ATPase:Ragulator:RagA,B:GDP:RagC,D:GDP binds SLC38A9:Arginine (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP:SLC38A9:Arg [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator:RRAGA,B:GDP:RRAGC,D:GDP [lysosomal membrane] (Homo sapiens)
        
        v-ATPase:Ragulator [lysosomal membrane] (Homo sapiens)
        
        v-ATPase [lysosomal membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by Insulin receptor (Homo sapiens)
    - Insulin receptor recycling (Homo sapiens)
      - ATP6AP1 binds V-ATPase (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
      - Endosome acidification (Homo sapiens)
        
        V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)

Transport of small molecules (Homo sapiens)

- Ion channel transport (Homo sapiens)
  - ATP6AP1 binds V-ATPase (Homo sapiens)
    - V-ATPase [endosome membrane] (Homo sapiens)
      - ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
    - V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
      - V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
- Iron uptake and transport (Homo sapiens)
  - Transferrin endocytosis and recycling (Homo sapiens)
    - ATP6AP1 binds V-ATPase (Homo sapiens)
      - V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
      - V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)
    - Acidification of Tf:TfR1 containing endosome (Homo sapiens)
      - V-ATPase:ATP6AP1 [endosome membrane] (Homo sapiens)
        
        V-ATPase [endosome membrane] (Homo sapiens)
        
        ATP6V1 [cytosol] (Homo sapiens)
        
        ATP6V1A trimer [cytosol] (Homo sapiens)
        
        ATP6V1A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P38606 ATP6V1A

Gene Names

ATP6V1A, ATP6A1, ATP6V1A1, VPP2

Chain

initiator methionine:, chain:1-617

Reference Genes

BioGPS Gene:523 ATP6V1A

COSMIC (genes):ATP6V1A ATP6V1A

CTD Gene:523 ATP6V1A

dbSNP Gene:523 ATP6V1A

ENSEMBL:ENSG00000114573 ATP6V1A

ENSEMBL_homo_sapiens_GENE:ENSG00000114573.12 ATP6V1A

HGNC:851 ATP6V1A

KEGG Gene (Homo sapiens):523 ATP6V1A

Monarch:523 ATP6V1A

NCBI Gene:523 ATP6V1A

OMIM:607027 ATP6V1A

UCSC:P38606 ATP6V1A

Reference Transcript

RefSeq:NM_001690.3 ATP6V1A

Other Identifiers

11718120_at

11718121_x_at

11718122_a_at

11751178_a_at

11756924_s_at

16944096

201971_PM_s_at

201971_s_at

201972_PM_at

201972_at

2636590

2636597

2636601

2636602

2636603

2636604

2636606

2636608

2636609

2636610

2636611

2636612

2636619

2636620

2636621

2636622

2636623

34889_at

34890_at

3910773

523

8081740

A_23_P211965

A_24_P396994

GE88476

GO:0000139

GO:0000166

GO:0000221

GO:0003824

GO:0005215

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005773

GO:0005794

GO:0005829

GO:0005886

GO:0005902

GO:0006811

GO:0006879

GO:0006914

GO:0007035

GO:0007040

GO:0007042

GO:0010008

GO:0015986

GO:0016020

GO:0016192

GO:0016241

GO:0016324

GO:0016469

GO:0016787

GO:0016874

GO:0016887

GO:0030133

GO:0030141

GO:0030665

GO:0031410

GO:0033176

GO:0033180

GO:0036295

GO:0043226

GO:0043231

GO:0046034

GO:0046933

GO:0046961

GO:0048388

GO:0051452

GO:0055065

GO:0055085

GO:0055086

GO:0061795

GO:0070062

GO:0097401

GO:0098850

GO:0140657

GO:1901135

GO:1902495

GO:1902600

GO:1904949

HMNXSV003015498

ILMN_1711516

L09235_at

PH_hs_0024782

TC03000583.hg

g4502304_3p_a_at

g6523820_3p_at

Participates

as an output of

MITF-M-dependent ATP6V1A gene expression (Homo sapiens)

as a component of

ATP6V1A trimer [cytosol] (Homo sapiens)

Inferred To

atp6v1a [cytosol] (Xenopus tropicalis)

ATP6V1A [cytosol] (Bos taurus)

ATP6V1A [cytosol] (Caenorhabditis elegans)

ATP6V1A [cytosol] (Canis familiaris)

ATP6V1A [cytosol] (Danio rerio)

ATP6V1A [cytosol] (Dictyostelium discoideum)

ATP6V1A [cytosol] (Drosophila melanogaster)

ATP6V1A [cytosol] (Gallus gallus)

ATP6V1A [cytosol] (Mus musculus)

ATP6V1A [cytosol] (Plasmodium falciparum)

ATP6V1A [cytosol] (Saccharomyces cerevisiae)

ATP6V1A [cytosol] (Schizosaccharomyces pombe)

ATP6V1A [cytosol] (Sus scrofa)

Atp6v1a [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_001681.2

Guide to Pharmacology - Targets

810

OpenTargets

ENSG00000114573

HPA

ENSG00000114573-ATP6V1A

GeneCards

P38606

Ensembl

ENSP00000515547, ENST00000703904, ENSP00000515548, ENSP00000515542, ENST00000703911, ENSP00000273398, ENST00000273398, ENST00000496747, ENSG00000114573, ENST00000703910, ENSP00000417545

PRO

P38606

Pharos - Targets

P38606

Orphanet

25319

HMDB Protein

HMDBP01342

PDB

6WM2, 6WM3, 6WM4, 7UNF, 6WLZ, 7U4T

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DOF2 MATRX			0.632	10
UniProt:Q96PV0 SYNGAP1	1	SYNGAP1 [cytosol] (R-HSA-5658217)	0.527	6
UniProt:Q9H444 CHMP4B	2	CHMP4B [cytosol] (R-HSA-917708) CHMP4B [endosome membrane] (R-HSA-9631202)	0.527	2
UniProt:Q8NEY4 ATP6V1C2	1	ATP6V1C2 [cytosol] (R-HSA-912573)	0.527	2
UniProt:P0DTC5 M	10	M [plasma membrane] (R-COV-9755780) N-glycan M [virion membrane] (R-COV-9694385) M [virion membrane] (R-COV-9694320) M [endocytic vesicle membrane] (R-COV-9694563) N-glycan M [endocytic vesicle membrane] (R-COV-9694738) M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694439) N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694446) M [endoplasmic reticulum membrane] (R-COV-9767620) nascent M [endoplasmic reticulum lumen] (R-COV-9694279) N-glycan M [endoplasmic reticulum membrane] (R-COV-9694684)	0.527	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12

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