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M [endoplasmic reticulum membrane]
Stable Identifier
R-COV-9767620
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum membrane
Synonyms
P0DTC5
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
SARS-CoV-2 M protein binds MAVS (Homo sapiens)
M:MAVS [endoplasmic reticulum membrane] (Homo sapiens)
M [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
M [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 modulates autophagy (Homo sapiens)
SARS-CoV-2 M protein binds MAP1LC3B (Homo sapiens)
MAP1LC3B:TUFM:M [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
TUFM:M [endoplasmic reticulum membrane] (Homo sapiens)
M [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
TUFM:M [endoplasmic reticulum membrane] (Homo sapiens)
M [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
SARS-CoV-2 M protein binds TUFM (Homo sapiens)
TUFM:M [endoplasmic reticulum membrane] (Homo sapiens)
M [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
M [endoplasmic reticulum membrane] (Severe acute respiratory syndrome coronavirus 2)
General
SARS-CoV-2 mRNA2 open reading frame has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).
External Reference Information
External Reference
UniProt:P0DTC5 M
Gene Names
M
Chain
chain:1-222
Participates
as an input of
SARS-CoV-2 M protein binds TUFM (Homo sapiens)
SARS-CoV-2 M protein binds MAVS (Homo sapiens)
as a component of
TUFM:M [endoplasmic reticulum membrane] (Homo sapiens)
M:MAVS [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
M [plasma membrane]
N-glycan M [virion membrane]
M [virion membrane]
M [endocytic vesicle membrane]
N-glycan M [endocytic vesicle membrane]
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
nascent M [endoplasmic reticulum lumen]
N-glycan M [endoplasmic reticulum membrane]
Inferred From
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(Human SARS coronavirus)
Disease
Name
Identifier
Synonyms
COVID-19
DOID:0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
PDB
7VGR
,
7VGS
,
8CTK
,
8CME
Interactors (59)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.733
11
UniProt:Q9UHD2 TBK1
5
pS-172,K48polyUb-TBK1 [cytosol]
(R-HSA-3249397)
p-TBK1 [cytosol]
(R-HSA-9008705)
K63polyUb-K30,K401-TBK1 [cytosol]
(R-HSA-9730430)
TBK1 [cytosol]
(R-HSA-166267)
p-S172-TBK1 [cytosol]
(R-HSA-168379)
0.681
10
UniProt:P0DTC4 E
9
N-glycan E [endoplasmic reticulum lumen]
(R-COV-9694754)
nascent E [endoplasmic reticulum lumen]
(R-COV-9694312)
3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9694305)
Ub-3xPalmC-E [endoplasmic reticulum lumen]
(R-COV-9694423)
Ub-3xPalmC-E [endoplasmic reticulum membrane]
(R-COV-9694465)
Ub-3xPalmC-E [Golgi membrane]
(R-COV-9694687)
Ub-3xPalmC-E [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698420)
Ub-3xPalmC-E [endocytic vesicle membrane]
(R-COV-9698422)
Ub-3xPalmC-E [virion membrane]
(R-COV-9698416)
0.674
5
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.674
6
UniProt:P0DTC5 M
10
M [plasma membrane]
(R-COV-9755780)
N-glycan M [virion membrane]
(R-COV-9694385)
M [virion membrane]
(R-COV-9694320)
M [endocytic vesicle membrane]
(R-COV-9694563)
N-glycan M [endocytic vesicle membrane]
(R-COV-9694738)
M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694439)
N-glycan M [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9694446)
M [endoplasmic reticulum membrane]
(R-COV-9767620)
nascent M [endoplasmic reticulum lumen]
(R-COV-9694279)
N-glycan M [endoplasmic reticulum membrane]
(R-COV-9694684)
0.665
4
UniProt:O75439 PMPCB
1
PMPCB [mitochondrial matrix]
(R-HSA-1299434)
0.643
3
UniProt:Q96HW7 INTS4
1
INTS4 [nucleoplasm]
(R-HSA-6807462)
0.643
3
UniProt:Q00765 REEP5
0.643
3
UniProt:Q96D53 COQ8B
1
COQ8B [mitochondrial inner membrane]
(R-HSA-9856289)
0.643
3
UniProt:Q5JRX3 PITRM1
1
PITRM1 [mitochondrial matrix]
(R-HSA-8986159)
0.643
3
UniProt:P05026 ATP1B1
1
ATP1B1 [plasma membrane]
(R-HSA-375071)
0.643
3
UniProt:Q9NQC3 RTN4
1
RTN4 [plasma membrane]
(R-HSA-194556)
0.643
3
UniProt:Q9BYX4 IFIH1
3
IFIH1 [cytosol]
(R-HSA-913536)
K48polyUb-IFIH1 [cytosol]
(R-HSA-3080557)
PolyUb-IFIH1 [cytosol]
(R-HSA-6782812)
0.621
3
UniProt:Q13114 TRAF3
4
TRAF3 R118W [cytosol]
(R-HSA-5602321)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 [cytosol]
(R-HSA-914241)
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
0.573
4
UniProt:P0DTC6 6
4
6 [nuclear envelope]
(R-COV-9727279)
6 [cytosol]
(R-COV-9708916)
6 [endoplasmic reticulum membrane]
(R-COV-9727295)
6 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9705293)
0.553
2
UniProt:Q16236 NFE2L2
13
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
0.547
2
UniProt:Q96JB5 CK5P3
0.547
2
UniProt:P08236 GUSB
9
GUSB R611W [lysosomal lumen]
(R-HSA-2318382)
GUSB R216W [lysosomal lumen]
(R-HSA-2318584)
GUSB A354V [lysosomal lumen]
(R-HSA-2318376)
GUSB R356* [lysosomal lumen]
(R-HSA-2318372)
GUSB [azurophil granule lumen]
(R-HSA-6799122)
GUSB [extracellular region]
(R-HSA-6806207)
GUSB [ficolin-1-rich granule lumen]
(R-HSA-6800967)
GUSB [lysosomal lumen]
(R-HSA-1678846)
GUSB S52F [lysosomal lumen]
(R-HSA-2318391)
0.547
2
UniProt:Q9UI26 IPO11
0.547
2
UniProt:Q96MT1 RN145
0.547
2
UniProt:O15063 GARRE1
1
KIAA0355 [cytosol]
(R-HSA-9691200)
0.547
2
UniProt:Q96RQ1 ERGI2
0.547
2
UniProt:O00482 NR5A2
1
NR5A2 [nucleoplasm]
(R-HSA-9011735)
0.547
2
UniProt:Q9C029 TRIM7
0.547
2
UniProt:Q9UBQ6 EXTL2
1
EXTL2 [endoplasmic reticulum membrane]
(R-HSA-8953372)
0.547
2
UniProt:Q86UA1 PRP39
0.547
2
IntAct:EBI-26608251 NC
0.541
4
UniProt:P11310 ACADM
1
ACADM [mitochondrial matrix]
(R-HSA-49491)
0.527
2
UniProt:Q9UBU6 FA8A1
0.527
2
UniProt:Q9Y6E2 5MP1
0.527
2
UniProt:Q15758 SLC1A5
1
SLC1A5 [plasma membrane]
(R-HSA-352376)
0.527
2
UniProt:Q9BSJ2 TUBGCP2
1
TUBGCP2 [cytosol]
(R-HSA-379275)
0.527
2
UniProt:P48556 PSMD8
2
PSMD8 [nucleoplasm]
(R-HSA-174318)
PSMD8 [cytosol]
(R-HSA-68808)
0.527
2
UniProt:Q96CW5 TUBGCP3
1
TUBGCP3 [cytosol]
(R-HSA-379276)
0.527
2
UniProt:Q9ULX6 AKAP8L
1
AKAP8L [nucleoplasm]
(R-HSA-9821364)
0.527
2
UniProt:Q6PML9 ZNT9
0.527
2
UniProt:Q9UDR5 AASS
1
AASS [mitochondrial matrix]
(R-HSA-70924)
0.527
2
UniProt:P13804 ETFA
1
ETFA(1-?) [mitochondrial matrix]
(R-HSA-169262)
0.527
2
UniProt:Q9BQT8 SLC25A21
1
SLC25A21 [mitochondrial inner membrane]
(R-HSA-372474)
0.527
2
UniProt:P38606 ATP6V1A
1
ATP6V1A [cytosol]
(R-HSA-912602)
0.527
2
UniProt:Q10713 PMPCA
1
PMPCA [mitochondrial matrix]
(R-HSA-1299450)
0.527
2
UniProt:Q96HR9 REEP6
0.527
2
UniProt:O95070 YIF1A
1
YIF1A [endoplasmic reticulum membrane]
(R-HSA-535599)
0.527
2
UniProt:Q9Y6D5 ARFGEF2
1
ARFGEF2 [cytosol]
(R-HSA-391301)
0.527
2
UniProt:Q9BW92 TARS2
1
TARS2(1-?) [mitochondrial matrix]
(R-HSA-379590)
0.527
2
UniProt:Q93084 ATP2A3
2
ATP2A3 [platelet dense tubular network membrane]
(R-HSA-427902)
ATP2A3 [endoplasmic reticulum membrane]
(R-HSA-391965)
0.527
2
UniProt:P27105 STOM
4
STOM [tertiary granule membrane]
(R-HSA-6800960)
STOM [plasma membrane]
(R-HSA-6806258)
STOM [azurophil granule membrane]
(R-HSA-6800997)
STOM [specific granule membrane]
(R-HSA-6799569)
0.527
2
UniProt:Q8NEW0 ZNT7
0.527
2
UniProt:Q7Z3C6 ATG9A
1
ATG9A [phagophore assembly site membrane]
(R-HSA-5671732)
0.527
2
UniProt:Q96ER3 SAAL1
0.527
2
UniProt:Q4KMQ2 ANO6
3
ANO6 [specific granule membrane]
(R-HSA-6799509)
ANO6 [plasma membrane]
(R-HSA-2684941)
ANO6 [tertiary granule membrane]
(R-HSA-6800903)
0.527
2
UniProt:P38435 GGCX
1
GGCX [endoplasmic reticulum membrane]
(R-HSA-159860)
0.527
2
UniProt:Q7L8L6 FASTKD5
1
FASTKD5 [mitochondrial matrix]
(R-HSA-9837206)
0.527
2
UniProt:Q9Y312 AAR2
0.527
2
UniProt:Q07021-PRO_0000018590 C1QBP
0.524
2
UniProt:P0DTD8 NS7B
0.519
4
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
0.483
2
UniProt:O95786 RIGI
4
PolyUb-DDX58 [cytosol]
(R-HSA-6782770)
K48polyUb-DDX58 [cytosol]
(R-HSA-3080568)
K63polyUb-DDX58 [cytosol]
(R-HSA-918191)
DDX58 [cytosol]
(R-HSA-168917)
0.463
3
UniProt:Q14164 IKBKE
5
monoSUMO1-K231-p-S172-IKBKE [nucleoplasm]
(R-HSA-4755535)
IKBKE [cytosol]
(R-HSA-450225)
p-S172-IKBKE [cytosol]
(R-HSA-450278)
K63polyUb-K30,K401-IKBKE [cytosol]
(R-HSA-9730436)
p-S172-IKBKE [nucleoplasm]
(R-HSA-4755521)
0.463
2
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