Reactome | p-T250,T255,T385,S437-MKNK1 [cytosol]

p-T250,T255,T385,S437-MKNK1 [cytosol]

Stable Identifier

R-HSA-947860

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S437,T250,T255,T385-MKNK1, p- MNK1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9BUB5 MKNK1

Gene Names

MKNK1, MNK1

Chain

chain:1-465

Reference Genes

BioGPS Gene:8569 MKNK1

COSMIC (genes):MKNK1 MKNK1

CTD Gene:8569 MKNK1

dbSNP Gene:8569 MKNK1

ENSEMBL:ENSG00000079277 MKNK1

HGNC:7110 MKNK1

KEGG:hsa:8569 MKNK1

Monarch:8569 MKNK1

NCBI Entrez Gene:8569 MKNK1

OMIM:606724 MKNK1

UCSC:Q9BUB5 MKNK1

Reference Transcript

Other Identifiers

11718812_a_at

11748830_a_at

11756858_a_at

11760649_a_at

1560720_3p_at

1560720_PM_at

1560720_at

16686648

209467_PM_s_at

209467_s_at

2410726

2410728

2410730

2410732

2410734

2410736

2410738

2410740

2410742

2410746

2410748

2410750

2410760

2410764

2410766

2410768

2410772

2410774

2410778

2410780

2410782

2410784

2410786

2410788

2410790

2410792

2410794

2410796

2410802

2410804

2410806

2410810

2410812

2410814

2410816

2410818

2410820

2410822

2410826

2410828

2410830

2410832

2410836

2410838

2410840

2410872

243256_PM_at

243256_at

3285393

3285394

35299_at

67726_at

7915846

8569

AB000409_at

A_23_P200126

GE789202

GE79378

GE819237

GO:0000166

GO:0003824

GO:0004672

GO:0004674

GO:0004683

GO:0005515

GO:0005516

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006417

GO:0006468

GO:0009931

GO:0016301

GO:0016740

GO:0035556

GO:0046872

GO:0106310

GO:0140096

HMNXSV003028434

Hs.187665.0.A1_3p_at

Hs2.376097.1.S1_3p_at

ILMN_1719677

ILMN_1725738

ILMN_1750429

PH_hs_0010986

PH_hs_0022191

PH_hs_0040498

TC01005450.hg

g12803828_3p_a_at

Inferred To

phospho-MKNK1 [cytosol] (Canis familiaris)

phospho-p-T250,T255,T385,S437-MKNK1 [cytosol] (Bos taurus)

phospho-p-T250,T255,T385,S437-MKNK1 [cytosol] (Drosophila melanogaster)

phospho-p-T250,T255,T385,S437-MKNK1 [cytosol] (Mus musculus)

phospho-p-T250,T255,T385,S437-MKNK1 [cytosol] (Rattus norvegicus)

phospho-p-T250,T255,T385,S437-MKNK1 [cytosol] (Sus scrofa)

phospho-p-T250,T255,T385,S437-MKNK1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-threonine at 250

Coordinate

250

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 255

Coordinate

255

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-threonine at 385

Coordinate

385

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 437

Coordinate

437

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_006711063.1, XP_054195311.1, XP_054195310.1, XP_054195309.1, XP_047288981.1, NP_001129025.1, XP_047288980.1, NP_945324.1, NP_003675.2, XP_016858148.1, XP_047288982.1

ZINC - World Drugs

MKNK1_HUMAN

Guide to Pharmacology - Targets

2104

OpenTargets

ENSG00000079277

ENSEMBL

ENST00000650508, ENST00000649800, ENSP00000498083, ENSP00000497380, ENSP00000498143, ENST00000650026, ENSG00000079277

ZINC - FDA approved

MKNK1_HUMAN

ZINC - Substances

MKNK1_HUMAN

ZINC - Biogenic

MKNK1_HUMAN

ZINC target

Q9BUB5

PRO

Q9BUB5

PDB

5WVD, 2HW6, 2Y9Q

ZINC - Investigational

MKNK1_HUMAN

HPA

ENSG00000079277-MKNK1

GeneCards

MKNK1

Pharos - Targets

Q9BUB5

ZINC - Predictions - Purchasable

MKNK1_HUMAN

HMDB Protein

HMDBP01482

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	18	p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) MAPK1 [cytosol] (R-HSA-59282) MAPK1 [nucleoplasm] (R-HSA-199960) p-T185-MAPK1 [cytosol] (R-HSA-9635773) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293)	0.818	11
UniProt:Q16539 MAPK14	7	p-T180,Y182-MAPK14 [nucleoplasm] (R-HSA-446227) p-T180,Y182-MAPK14 [cytosol] (R-HSA-428935) MAPK14 [cytosol] (R-HSA-428933) MAPK14 [nucleoplasm] (R-HSA-446223) MAPK14 [secretory granule lumen] (R-HSA-6803300) MAPK14 [extracellular region] (R-HSA-6806453) MAPK14 [ficolin-1-rich granule lumen] (R-HSA-6803280)	0.798	7
UniProt:Q04637 EIF4G1	2	p-S1108,S1148,S1192-EIF4G1 [cytosol] (R-HSA-165762) EIF4G1 [cytosol] (R-HSA-72584)	0.564	3
UniProt:Q9BUB5 MKNK1	1	p-T250,T255,T385,S437-MKNK1 [cytosol] (R-HSA-947860)	0.564	5
UniProt:Q96CV9 OPTN	6	p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840) OPTN [cytosol] (R-HSA-9687907) p-S177-OPTN [cytosol] (R-HSA-2562525) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [recycling endosome membrane] (R-HSA-8854141)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	18
IntAct:EBI-25865403 EHD27213144			0.556	3
UniProt:Q03060-25 CREM			0.556	3
UniProt:P54253 ATX1			0.556	6

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