Reactome | p-S1108,S1148,S1192-EIF4G1 [cytosol]

p-S1108,S1148,S1192-EIF4G1 [cytosol]

Stable Identifier

R-HSA-165762

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF4G-P

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General

Serine residues 1108, 1148, 1192 of the EIF4G1 isoform in Raught et al. (2000) correspond to serine residues 1147, 1185, and 1231 of the UniProt reference sequence.

Literature References

PubMed ID	Title	Journal	Year
10654941	Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI Sonenberg, N, Aebersold, R, Gradi, A, Raught, B, Gygi, SP, Imataka, H, Gingras, AC, Morino, S	EMBO J	2000

External Reference Information

External Reference

UniProt:Q04637 EIF4G1

Gene Names

EIF4G1, EIF4F, EIF4G, EIF4GI

Chain

initiator methionine:, chain:1-1599

Reference Genes

BioGPS Gene:1981 EIF4G1

COSMIC (genes):EIF4G1 EIF4G1

CTD Gene:1981 EIF4G1

dbSNP Gene:1981 EIF4G1

ENSEMBL:ENSG00000114867 EIF4G1

ENSEMBL_homo_sapiens_GENE:ENSG00000114867.22 EIF4G1

HGNC:3296 EIF4G1

KEGG Gene (Homo sapiens):1981 EIF4G1

Monarch:1981 EIF4G1

NCBI Gene:1981 EIF4G1

OMIM:600495 EIF4G1

UCSC:Q04637 EIF4G1

Reference Transcript

Other Identifiers

11726566_a_at

11726567_a_at

11726568_x_at

1306_at

16948909

1981

208624_PM_s_at

208624_s_at

208625_3p_s_at

208625_PM_s_at

208625_s_at

2655689

2655690

2655691

2655692

2655693

2655695

2655696

2655697

2655698

2655699

2655700

2655701

2655702

2655704

2655705

2655706

2655707

2655708

2655709

2655711

2655712

2655713

2655714

2655715

2655716

2655717

2655718

2655719

2655720

2655721

2655722

2655723

2655725

2655727

2655728

2655729

2655730

2655731

2655732

2655733

2655734

2655735

2655737

2655738

2655739

2655741

2655743

2655745

2655747

2655750

2655751

2655752

2655753

2655754

2655756

32844_at

57332_r_at

69222_at

8084439

A_23_P218892

GE62301

GO:0000278

GO:0001662

GO:0002181

GO:0002191

GO:0003723

GO:0003729

GO:0003743

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0006413

GO:0006417

GO:0006446

GO:0006914

GO:0008135

GO:0008190

GO:0009059

GO:0010494

GO:0010507

GO:0010801

GO:0016020

GO:0016281

GO:0030154

GO:0030182

GO:0030307

GO:0030324

GO:0031047

GO:0031369

GO:0031669

GO:0033138

GO:0034330

GO:0035278

GO:0036211

GO:0036493

GO:0042802

GO:0043226

GO:0045182

GO:0045471

GO:0045666

GO:0048856

GO:0051247

GO:0060090

GO:0065003

GO:0080135

GO:0097009

GO:0098794

GO:1900087

GO:1904377

GO:1905537

GO:1905606

GO:1905612

HMNXSV003026478

Hs.211568.1.A1_3p_a_at

ILMN_1672902

ILMN_1678244

ILMN_1768470

ILMN_2370772

PH_hs_0030188

TC03001000.hg

TC03002693.hg

g3941723_3p_s_at

Participates

as an output of

Phosphorylation and activation of eIF4G by activated S6K1 (Homo sapiens)

Other forms of this molecule

EIF4G1 [cytosol]

Inferred To

phospho-tif471 [cytosol] (Schizosaccharomyces pombe)

phospho-EIF4G1 [cytosol] (Bos taurus)

phospho-EIF4G1 [cytosol] (Canis familiaris)

phospho-EIF4G1 [cytosol] (Sus scrofa)

phospho-ifg-1 [cytosol] (Caenorhabditis elegans)

phospho-eif4g [cytosol] (Dictyostelium discoideum)

phospho-eIF4G1 [cytosol] (Drosophila melanogaster)

phospho-Eif4g1 [cytosol] (Mus musculus)

phospho-Eif4g1 [cytosol] (Rattus norvegicus)

phospho-TIF4631 [cytosol] (Saccharomyces cerevisiae)

phospho-eif4g1 [cytosol] (Xenopus tropicalis)

Homologues of p-S1108,S1148,S1192-EIF4G1 [cytosol] (Drosophila melanogaster)

Homologues of p-S1108,S1148,S1192-EIF4G1 [cytosol] (Plasmodium falciparum)

phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol] (Gallus gallus)

phospho-p-S1108,S1148,S1192-EIF4G1 [cytosol] (Plasmodium falciparum)

phospho-eIF4G2 [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-serine at 1147

Coordinate

1147

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1185

Coordinate

1185

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 1231

Coordinate

1231

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_937884.1, NP_886553.3, NP_937885.1, NP_004944.3

OpenTargets

ENSG00000114867

HPA

ENSG00000114867-EIF4G1

GeneCards

Q04637

Ensembl

ENST00000434061, ENSP00000338020, ENST00000392537, ENST00000346169, ENST00000342981, ENST00000382330, ENSP00000376320, ENSP00000411826, ENSP00000416255, ENST00000424196, ENSP00000371767, ENSP00000316879, ENSP00000317600, ENSG00000114867, ENSP00000391935, ENST00000352767, ENST00000414031, ENST00000350481, ENSP00000343450

PRO

Q04637

Pharos - Targets

Q04637

Orphanet

20634

PDB

5EIR, 4F02, 8J7R, 5T46, 6ZMW, 5EHC, 5EI3, 8HUJ, 1LJ2, 2W97, 4AZA, 8OZ0, 1UG3, 5ZK5

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P60842 EIF4A1	1	EIF4A1 [cytosol] (R-HSA-72573)	0.964	17
UniProt:P06730 EIF4E	1	EIF4E [cytosol] (R-HSA-72578)	0.924	13
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.835	6
UniProt:Q14240 EIF4A2	1	EIF4A2 [cytosol] (R-HSA-72575)	0.656	4
UniProt:Q9BWF3-1 RBM4			0.591	4
UniProt:Q9UGR2 Z3H7B			0.567	3
UniProt:Q9BUB5 MKNK1	1	p-T250,T255,T385,S437-MKNK1 [cytosol] (R-HSA-947860)	0.564	3
UniProt:P55884 EIF3B	1	EIF3B [cytosol] (R-HSA-72542)	0.564	2
UniProt:P23116	1	Eif3a [cytosol] (R-MMU-72546)	0.564	2
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.557	3
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.528	3
UniProt:P03372 ESR1	10	p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) p-S167-ESR1 [cytosol] (R-HSA-9841254) Me260-ESR1 [cytosol] (R-HSA-9632177) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.527	3
UniProt:Q06787 FMR1			0.527	2
UniProt:Q13112 CAF1B			0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:O75822 EIF3J	1	EIF3J [cytosol] (R-HSA-72534)	0.524	2
UniProt:Q9J0X9 Q9J0X9			0.499	3
UniProt:Q14103-4 HNRNPD	2	Ub-HNRNPD-4 [cytosol] (R-HSA-451232) HNRNPD-4 [cytosol] (R-HSA-450442)	0.499	3
UniProt:Q13283 G3BP1	1	G3BP1 [cytosol] (R-HSA-9729517)	0.491	2
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.483	2
UniProt:P62280 RPS11	2	RPS11 [nucleoplasm] (R-HSA-6791212) RPS11 [cytosol] (R-HSA-72327)	0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	7
UniProt:P51116 FXR2			0.483	2
UniProt:P06748 NPM1	11	monoSUMO1-K263-NPM1 [nucleoplasm] (R-HSA-4086039) polySUMO2,3-K263-NPM1 [nucleoplasm] (R-HSA-4086056) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [nucleoplasm] (R-HSA-9725010) NPM1(1-117)-p-7Y-ALK(1068-1620) fusion [cytosol] (R-HSA-9730703) NPM1(1-117)-ALK(1068-1620) fusion [cytosol] (R-HSA-9730697) NPM1(1-117)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9699861) NPM1(1-117)-ALK(1058-1620) fusion [cytosol] (R-HSA-9699834) NPM1 [granular component] (R-HSA-9017702) NPM1 [nucleoplasm] (R-HSA-606320) NPM1 [cytosol] (R-HSA-3008211) p-S4-NPM1 [cytosol] (R-HSA-6801679)	0.483	2
UniProt:Q00721 NSP3			0.482	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.462	2

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