Reactome | Estrogen-dependent nuclear events downstream of ESR-membrane signaling

Estrogen-dependent nuclear events downstream of ESR-membrane signaling

Stable Identifier

R-HSA-9634638

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Estrogen-dependent nuclear events downstream of ESR-membrane signaling

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Although membrane-localized estrogen receptors stimulate rapid, transcription-independent responses such as calcium mobilization and alterations to the fibronectin matrix to affect cell migration, among others, the pathways activated by rapid signaling may also ultimately affect nuclear events. Activation of MAPK and PI3K/AKT pathways downstream of membrane-localized ESR1 contributes to estrogen-responsive changes in cellular proliferation and survival in part through changes in gene expression (reviewed in Levin et al, 2005; Lange et al, 2007; Le Romancer et al, 2011).

Literature References

PubMed ID	Title	Journal	Year
17037979	Integration of rapid signaling events with steroid hormone receptor action in breast and prostate cancer Lange, CA, Gioeli, D, Hammes, SR, Marker, PC	Annu. Rev. Physiol.	2007
15705661	Integration of the extranuclear and nuclear actions of estrogen Levin, ER	Mol. Endocrinol.	2005
21680538	Cracking the estrogen receptor's posttranslational code in breast tumors Le Romancer, M, Poulard, C, Cohen, P, Sentis, S, Renoir, JM, Corbo, L	Endocr. Rev.	2011