CLTC(2-1634)-p-7Y ALK(1059-1620) fusion [cytosol]

Stable Identifier
R-HSA-9710854
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
fullName evidence="36 37"Clathrin heavy chain 1, CLH1_HUMAN
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
12920229 ALK+, CD30-, CD20- large B-cell lymphoma containing anaplastic lymphoma kinase (ALK) fused to clathrin heavy chain gene (CLTC)

Chikatsu, N, Kojima, H, Suzukawa, K, Shinagawa, A, Nagasawa, T, Ozawa, H, Yamashita, Y, Mori, N

Mod Pathol 2003
21494621 Inhibition of anaplastic lymphoma kinase (ALK) activity provides a therapeutic approach for CLTC-ALK-positive human diffuse large B cell lymphomas

Cerchietti, L, Damm-Welk, C, Vater, I, Klapper, W, Harder, L, Pott, C, Yang, SN, Reiter, A, Siebert, R, Melnick, A, Woessmann, W

PLoS One 2011
External Reference Information
External Reference
Gene Names
CLTC, CLH17, CLTCL2, KIAA0034
Chain
initiator methionine:1, chain:2-1675
Reference Transcript
Other Identifiers
0004810736
11739027_at
11739028_s_at
11739029_a_at
11739030_s_at
11746341_a_at
1213
16836564
200614_at
3728897
3728898
3729173
3729174
3729175
3729177
3729178
3729179
3729181
3729183
3729184
3729186
3729188
3729189
3729190
3729191
3729193
3729194
3729195
3729196
3729197
3729199
3729201
3729202
3729203
3729204
3729205
3729206
3729207
3729208
3729209
3729210
3729211
3729212
3729213
3729214
3729216
3729218
3729223
3729224
3729225
3729226
3729227
3729228
3729229
3729230
41159_at
8008834
84461_at
91168_at
A_14_P116029
A_14_P122089
A_23_P118544
A_33_P3274731
A_33_P3353170
D21260_at
GE57114
GO:0000278
GO:0001649
GO:0002376
GO:0003674
GO:0003723
GO:0003725
GO:0005198
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005764
GO:0005768
GO:0005773
GO:0005794
GO:0005819
GO:0005829
GO:0005856
GO:0005886
GO:0005905
GO:0005925
GO:0005975
GO:0006810
GO:0006886
GO:0006892
GO:0006898
GO:0006914
GO:0007010
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0009056
GO:0009058
GO:0015031
GO:0016020
GO:0016192
GO:0019886
GO:0019899
GO:0019901
GO:0022607
GO:0030118
GO:0030130
GO:0030132
GO:0030136
GO:0030154
GO:0030659
GO:0030669
GO:0031410
GO:0031623
GO:0032051
GO:0032588
GO:0032802
GO:0032991
GO:0033572
GO:0034383
GO:0036020
GO:0042147
GO:0042470
GO:0043226
GO:0044281
GO:0045334
GO:0048268
GO:0048856
GO:0050750
GO:0051301
GO:0060071
GO:0060236
GO:0061024
GO:0065003
GO:0070062
GO:0071439
GO:0072583
GO:0072686
GO:0097718
GO:0150093
GO:1900126
GO:1903077
GO:1903561
GO:1990381
GO:1990498
HMNXSV003026476
HMNXSV003043633
ILMN_1756779
PH_hs_0022888
TC17000725.hg
g4758011_3p_at
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 1059 to 1620 at 1635 from UniProt:Q9UM73 ALK
Coordinate
1635
Name
Replacement of residues 1634 to 1634 by YV
Name
O4'-phospho-L-tyrosine at 1096
Coordinate
1096
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1278
Coordinate
1278
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1282
Coordinate
1282
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1283
Coordinate
1283
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1358
Coordinate
1358
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1507
Coordinate
1507
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1604
Coordinate
1604
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Cross References
RefSeq
OpenTargets
ZINC - Substances
ZINC target
PRO
GlyGen
PDB
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
Orphanet
HMDB Protein
Interactors (8)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q14164 IKBKE  4 0.589 2
 UniProt:O14920 IKBKB  3 0.536 2
 UniProt:P10242 MYB  1 0.499 4
 UniProt:P49407 ARRB1  5 0.491 3
 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]  7 0.462 2
 UniProt:P03372 ESR1  8 0.462 2
 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate [ChEBI:16618]  6 0.462 2
 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]  6 0.462 2
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