Reactome | FBXO17 [cytosol]

FBXO17 [cytosol]

Stable Identifier

R-HSA-976036

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

F-box only protein 17, FBX17_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO17 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO17 [cytosol] (Homo sapiens)
      - NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO17 [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO17 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO17 [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO17 [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO17 [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO17 [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL1 E3 ligase complex [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO17 [cytosol] (Homo sapiens)
    - MyrG-DCUN1D3 binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase complex:MyrG-DCUN1D3 [plasma membrane] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO17 [cytosol] (Homo sapiens)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO17 [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL1 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO17 [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL1 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL1 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        SCF E3 ubiquitin ligase [cytosol] (Homo sapiens)
        
        F-box protein [cytosol] (Homo sapiens)
        
        FBXO17 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96EF6 FBXO17

Gene Names

FBXO17, FBG4, FBX17, FBX26, FBXO26

Chain

chain:1-278

Reference Genes

BioGPS Gene:115290 FBXO17

COSMIC (genes):FBXO17 FBXO17

CTD Gene:115290 FBXO17

dbSNP Gene:115290 FBXO17

ENSEMBL:ENSG00000269190 FBXO17

HGNC:18754 FBXO17

KEGG:hsa:115290 FBXO17

Monarch:115290 FBXO17

NCBI Gene:115290 FBXO17

OMIM:609094 FBXO17

UCSC:Q96EF6 FBXO17

Reference Transcript

Other Identifiers

115290

11728897_x_at

11754827_x_at

16872152

220233_PM_at

220233_at

3861787

3861788

3861789

3861790

3861791

3861792

3861793

3861794

3861795

3861796

3861797

3861798

3861799

3861800

3861801

3861802

3861803

3861805

3861807

3861810

3861811

3861813

70815_at

70820_at

80272_at

8036676

8036686

A_23_P101871

A_23_P395911

A_24_P151959

GE82996

GO:0003824

GO:0005515

GO:0005737

GO:0005829

GO:0006516

GO:0016740

GO:0019005

GO:0030163

GO:0031146

GO:0036503

GO:0061630

GO:0140096

GO:1901135

HMNXSV003000498

HMNXSV003025690

ILMN_1714428

ILMN_1743898

ILMN_1789274

ILMN_2368535

PH_hs_0025184

TC19002701.hg

g13376364_3p_at

Participates

as a member of

F-box protein [cytosol] (Homo sapiens)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

Fbxo17 [cytosol] (Mus musculus)

Fbxo17 [cytosol] (Rattus norvegicus)

fbxo27 [cytosol] (Xenopus tropicalis)

FBXO17 [cytosol] (Caenorhabditis elegans)

FBXO17 [cytosol] (Canis familiaris)

FBXO17 [cytosol] (Sus scrofa)

Cross References

ENSEMBL

ENSP00000489327, ENSP00000488997, ENST00000595329, ENSG00000282954, ENSG00000269190, ENST00000634982, ENST00000635115, ENST00000292852, ENSP00000292852, ENSP00000470361

OpenTargets

ENSG00000269190

GeneCards

FBXO17

HPA

ENSG00000269190-FBXO17

PRO

Q96EF6

Pharos - Targets

Q96EF6

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P63208 SKP1	2	SKP1 [cytosol] (R-HSA-174150) SKP1 [nucleoplasm] (R-HSA-187538)	0.895	19
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.737	10
UniProt:P10809 HSPD1	6	HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.527	3
UniProt:O60551 NMT2	1	NMT2 [cytosol] (R-HSA-184377)	0.527	3

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